Can Gentamicin-collagen Sponges Prevent Seroma Formation Following Mastectomy?

Wolde, Britt ten; Wildenberg, Frits J. H. van den; Polat, Fatih; Wilt, Johannes H. W. de; Strobbe, Luc J. A.

doi:10.1016/j.clbc.2018.02.011

Cited by 8 publications

(4 citation statements)

References 29 publications

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“…Many surgical methods have been described that help to reduce seroma formation. 14 Collagen sponges 15 or surgical adhesives 16 were found to be effective in reducing seroma aspirations and complications. However, none of these methods is a definitive solution because of the complex mechanism of seroma development.…”

Section: Discussionmentioning

confidence: 99%

The effect of thoracic paravertebral block on seroma reduction in breast surgery – a randomized controlled trial

Kuş

Yörükoğlu

Aksu

et al. 2020

Brazilian Journal of Anesthesiology (English Edition)

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Section: Discussionmentioning

confidence: 99%

The effect of thoracic paravertebral block on seroma reduction in breast surgery – a randomized controlled trial

Kuş

Yörükoğlu

Aksu

et al. 2020

Brazilian Journal of Anesthesiology (English Edition)

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“…Similarly, Wong et al 9 found that applying mupirocin at the catheter outlet was safe and decreased wound infection rates. A retrospective cohort study comparing the incidence of SSI after conventional treatment and gentamicin-collagen sponge prophylaxis in patients undergoing mastectomy showed that the application of gentamicin-collagen sponges reduced the incidence of SSI 10 . However, because different medicines have different effects, the optimal drug regimen remains unclear.…”

Section: Introductionmentioning

confidence: 99%

Effect of Different Local Antibiotic Regimens on Prevention of Postoperative Infection in Clean Surgical Wounds: A Systematic Review and Network Meta-analysis

Pan,

Cui,

et al. 2024

Adv Skin Wound Care

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OBJECTIVE To compare the efficacy of several local antibiotic regimens in preventing surgical site infection (SSI) in clean surgical wounds. DATA SOURCES The authors searched CNKI (China National Knowledge Infrastructure), the VIP (VIP information resource integration service platform), Wanfang Data knowledge service platform (WANFANG), SinoMed, Cochrane Library, EMBASE, and PubMed. STUDY SELECTION A total of 20 randomized controlled trials published between January 1, 2000 and April 1, 2021 were included in this meta-analysis. DATA EXTRACTION Authors extracted the name of the first author, publication date, country, type of surgery, follow-up time, mean age of participants, sample size of each group, interventions, outcome indicators, and study type from each article. DATA SYNTHESIS The overall effectiveness of eight local managements in reducing the incidence of the SSI effect were compared through the SUCRA (surface under the cumulative ranking curve) probabilities. The results of a network meta-analysis demonstrated that gentamicin ointment (odds ratio [OR], 0.16; 95% CI, 0.04–0.60), mupirocin ointment (OR, 0.44; 95% CI, 0.21–0.94), and gentamicin soaking of the graft (OR, 0.63; 95% CI, 0.44–0.91) significantly reduced the incidence of SSI compared with control. Further, vancomycin soaking of the graft (86.7%) ranked first, followed by gentamicin ointment (81.1%), gentamicin irrigation (79.9%), mupirocin ointment (56.8%), triple antibiotic ointment (47.8%), gentamicin soaking of the graft (42.3%), and vancomycin powder (22.1%); ampicillin powder (17.8%) was the least effective drug. CONCLUSIONS The findings indicate that local antibiotics combined with conventional antibiotics in the wound before wound closure are effective in reducing the incidence of SSI in clean surgical wounds. Vancomycin inoculation of the graft exhibited the best effect.

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“…In addition to the use of tissue adhesives or sutures to close the dead space developed after mastectomy, various expensive biological agents have been used to reduce seroma development. 5,[8][9][10][11][12][13][14] The common point of studies to reducing seroma and improving results can be considered to close the dead space in the surgical field. 8,10 When the methods used to close this gap were evaluated, it was seen that they were not superior to each other.…”

Section: Introductionmentioning

confidence: 99%

Prospective Study on Avoiding Seroma Formation by Flap Fixation After Modified Radical Mastectomy

Hakseven

Avşar

Çetindağ

et al. 2023

The American Surgeon™

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Introduction Seroma development after mastectomy is a common complication. Continued seroma causes increased outpatient visits, repeated aspirations, infection, delayed healing, delayed adjuvant therapy, and increased cost. Various treatments are being attempted to prevent and reduce seroma development. We examined the effects of flap fixation on seroma using absorbable sutures after modified radical mastectomy (MRM). Methods The prospectively recorded data of patients who underwent surgery for breast cancer were analyzed retrospectively. 72 consecutive patients who underwent MRM were included in the study. Patients who underwent MRM in the same way by the same surgeon were divided into two groups: the group whose wound was closed by fixing the flap to the chest wall with an absorbable suture (group A), and the group whose wound was closed with the classical method (group B). The groups were compared in terms of seroma development, clinicopathological data, and early complications. Results Drain removal time and the total amount of drained fluid in group A patients were significantly lower than drain removal time and the total amount of drained fluid in group B patients ( P < .001). Similarly, the amount of aspirated seroma in the control examinations of group A patients was significantly lower than that in group B ( P < .05). Group B needed re-aspiration significantly more than group A ( P < .05). Conclusions Flap fixation with suture after MRM is a method that reduces seroma formation and the amount of drained fluid, enables early removal of the drain, prevents delay in starting adjuvant treatment, is more comfortable for the patient and physician, and is also inexpensive.

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Can Gentamicin-collagen Sponges Prevent Seroma Formation Following Mastectomy?

Cited by 8 publications

References 29 publications

The effect of thoracic paravertebral block on seroma reduction in breast surgery – a randomized controlled trial

The effect of thoracic paravertebral block on seroma reduction in breast surgery – a randomized controlled trial

Effect of Different Local Antibiotic Regimens on Prevention of Postoperative Infection in Clean Surgical Wounds: A Systematic Review and Network Meta-analysis

Prospective Study on Avoiding Seroma Formation by Flap Fixation After Modified Radical Mastectomy

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