Can Foveal Avascular Zone (FAZ) Assessment By OCT Angiography, Used For Grading Of Diabetic Retinopathy?

Khadamy, Joobin

doi:10.15406/aovs.2016.05.00160

Cited by 5 publications

(4 citation statements)

References 19 publications

(40 reference statements)

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“…Adding quantitative values including FAZ size to the current grading system may improve DR scaling system to a more trackable clinically applicable scaling. [ 109 110 111 ]…”

Section: Discussionmentioning

confidence: 99%

An update on optical coherence tomography angiography in diabetic retinopathy

Khadamy¹,

Aghdam²,

Falavarjani³

2018

J Ophthalmic Vis Res

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Optical coherence tomography angiography (OCTA) is a novel non-invasive imaging modality for 3-dimensional visualization of retinal and optic nerve capillary networks. In this article, a comprehensive review of relevant original articles in the PubMed database was performed using the search terms “diabetic retinopathy,” “diabetic macular edema,” “diabetes mellitus,” and “optical coherence tomography angiography.” OCTA was found to detect microvascular changes early in diabetes mellitus, even before they become clinically evident. Morphological and qualitative assessment of vascular changes can help to determine the pathophysiological processes, activity, treatment, and follow-up of diabetic retinopathy (DR). Vessel density and foveal avascular zone are the most investigated quantified indices shown to be early predictors of DR, correlated to DR severity and visual function, and useful in predicting response to treatment. OCTA has shown to be a promising alternative to fluorescein angiography in the management of DR. Further studies are warranted to determine the role of OCTA in the routine clinical management of DR.

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“…Adding quantitative values including FAZ size to the current grading system may improve DR scaling system to a more trackable clinically applicable scaling. [ 109 110 111 ]…”

Section: Discussionmentioning

confidence: 99%

An update on optical coherence tomography angiography in diabetic retinopathy

Khadamy¹,

Aghdam²,

Falavarjani³

2018

J Ophthalmic Vis Res

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“…[21] OCTA believed to be more accurate than FFA to demarcate and measure the FAZ, as it is not obscured by leakages, pooling or staining from fluorescein. [22] On the other hand, data in the literature regarding the FAZ area in diabetic patients without DR are conflicting. Kim et al and some other research groups reported a noted enlargement of the FAZ in NDR group in comparison with the control group.…”

Section: Discussionmentioning

confidence: 99%

Assessment of morphological and functional alterations in patients with early stage of non-proliferative diabetic retinopathy by optical coherence tomography angiography and microperimetry

Zhu

Liu²

2019

Preprint

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Background To analyze the optical coherence tomography angiography(OCTA) and microperimetry features in diabetic patients without diabetic retinopathy(NDR group) and patients with early stage of non-proliferative diabetic retinopathy(NPDR group). Methods This was a cross-sectional study including 24 eyes of the NDR group, 24 eyes of the NPDR group, and 24 eyes of healthy volunteers(control group). OCTA was used to measure foveal avascular zone(FAZ), vessel flow density of superficial capillary plexus(SCP) and deep capillary plexus(DCP) in the macular area(3×3mm). The latest version of microperimeter, MP-3, was used to quantitate retinal light sensitivity and fixation stability in the central 10° of the macular region. Results The NPDR group had a larger FAZ area, reduced vessel flow densities of both SCP and DCP, deceased retinal sensitivity and less stable fixation compared with the control group. Statistical differences were only found in the FAZ area, vessel flow density of DCP and retinal sensitivity between the NDR and the NDPR group. Conclusions The FAZ enlargement, vessel flow density decrease and retinal sensitivity reduction may be morphological and functional indicators of progression of diabetic retinopathy. Microvascular alterations in deep capillary plexus may precede superficial capillary alterations in diabetic retinopathy.

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“…One of the promising features of this technology is that beside qualitative data, it provides quantitative data regarding retinal and choroidal structural and vascular indices like Vascular Density (VD), Foveal Avascular Zone (FAZ), etc. Feasible Quantitative data provided by OCTA; may revolutionize current ophthalmic practice in regards of predicting [2,3], grading [4,5], following up treatment in patients with important vascular diseases like diabetic retinopathy, retinal vein obstruction, choroidal neovascularization, etc. [6][7][8][9][10].…”

Section: Introductionmentioning

confidence: 99%

“…Then, these data could be used for everyday clinical practices. For an instance, quantitative assessment of Foveal Avascular Zone (FAZ) could be useful in optimal selection of therapy in patients with Diabetic Macular Edema (DME) [11] or even grading the severity of Diabetic Retinopathy (DR) [5,12]. It has also shown that FAZ metrics could change in response to treatment [6] so it could be used in following up patients.…”

Section: Introductionmentioning

confidence: 99%

Optical Coherence Tomography Angiography (OCTA) in Ophthalmology; Technology, Pros, Cons and Commercial Prototypes

Khadamy¹

2017

JOJO

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The OCTA is a novel evolving imaging technology which utilizes motion contrast to visualize retinal and choroidal vessels. It showed promises to be used in predicting, grading, guiding and following treatment of important ocular vascular diseases. The main advantages of the OCTA are being non-invasive; being blue light and dye free and providing high quality images in a relatively short time. It has alleviated important limitations of Fluorescein Angiography (FA), but still it is not considered as a complete substitute of FA, by experts. The Combined FA/ICGA and OCTA imaging systems are introduced to the market. It may have the advantages of the both systems, while having the least limitations. Resolution of images, field of view, depth of images and scan speed are important factors when choosing a device. But one should also take into account that higher image quality needs more time to be acquisitioned. It could be challenging in busy clinics. In this article we compared FA and OCTA and also compared widely available commercial prototype of OCTA devices.

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Can Foveal Avascular Zone (FAZ) Assessment By OCT Angiography, Used For Grading Of Diabetic Retinopathy?

Cited by 5 publications

References 19 publications

An update on optical coherence tomography angiography in diabetic retinopathy

An update on optical coherence tomography angiography in diabetic retinopathy

Assessment of morphological and functional alterations in patients with early stage of non-proliferative diabetic retinopathy by optical coherence tomography angiography and microperimetry

Optical Coherence Tomography Angiography (OCTA) in Ophthalmology; Technology, Pros, Cons and Commercial Prototypes

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