Can first-trimester aspartate aminotransferase/platelet ratio index score predict intrahepatic cholestasis of pregnancy?

Gök, Koray

doi:10.14744/hf.2022.2022.0031

Cited by 1 publication

(4 citation statements)

References 26 publications

(36 reference statements)

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“…APRI scores in the ICP group were correlated with composite adverse outcomes. These results were compatible with previous studies 18–20 . However, higher composite adverse outcomes in the severe ICP group than in the mild ICP group and a correlation between APRI scores and serum bile acid levels could not be documented.…”

Section: Discussionsupporting

confidence: 90%

“…In a study by Gok et al, the APRI scores and AST and ALT levels in both the first and third trimesters were significantly higher in the ICP group. In their ROC analysis, the cutoff value of the first‐trimester APRI score for predicting ICP was accepted as ≥0.148, with a sensitivity of 79.6% and specificity of 56.5% 19 …”

Section: Discussionmentioning

confidence: 99%

“…These results were compatible with previous studies. [18][19][20] However, higher composite adverse outcomes in the severe ICP group than in the mild ICP group and a correlation between APRI scores and serum bile acid levels could not be documented. This may be interpreted as composite adverse outcomes being seen in cases with lower serum bile acid levels.…”

Section: Cs Indications N (%)mentioning

confidence: 92%

“…In their ROC analysis, the cutoff value of the firsttrimester APRI score for predicting ICP was accepted as ≥0.148, with a sensitivity of 79.6% and specificity of 56.5%. 19 Although the utility of APRI in the prediction of ICP development and prognosis has been investigated in various studies, our knowledge is still limited due to the heterogeneous design of the studies and relatively small number of cases. For this reason, the present study had superiorities such as high number of participants and inclusion of numerous study parameters.…”

Section: Cs Indications N (%)mentioning

confidence: 99%

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Role of aspartate aminotransferase to platelet ratio in the prediction and prognosis of intrahepatic cholestasis of pregnancy: A case–control study from a tertiary center

Peker

İpek

Ağaoğlu

et al. 2023

Intl J Gynecology & Obste

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ObjectiveTo evaluate the aspartate aminotransferase to platelet ratio (APRI) score as a predictive and prognostic test in intrahepatic cholestasis of pregnancy (ICP).MethodsThis study was conducted in 198 patients diagnosed with ICP and 204 healthy pregnant women who presented to a tertiary center between 2019 and 2022. APRI scores; laboratory findings in the first, second, and third trimesters; and perinatal outcomes were compared between the two groups. The ICP group was evaluated for correlation between APRI scores and composite adverse outcomes. Two different receiver operating characteristic analyses were performed to determine optimal cutoff values of predictive APRI score of ICP and composite adverse outcomes in patients with ICP.ResultsAspartate aminotransferase values and APRI scores were significantly higher in the ICP group in all trimesters (P < 0.001). The optimal cutoff values of APRI scores to predict ICP for the first, second, and third trimesters were 0.101 (79.7% sensitivity, 79.6% specificity), 0.103 (78.4% sensitivity, 76.3% specificity), and 0.098 (72.5% sensitivity, 72% specificity), respectively. APRI scores were statistically higher in patients with ICP with composite adverse outcomes in all trimesters (P values of 0.03, 0.04, and 0.01, respectively).ConclusionAPRI score was found to be a valuable predictor of ICP and its adverse outcomes during the entire pregnancy.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 99%