Can Exposure to Environmental Pollutants Be Associated with Less Effective Chemotherapy in Cancer Patients?

Lagunas‐Rangel, Francisco Alejandro; Liu, Wen; Schiöth, Helgi B.

doi:10.3390/ijerph19042064

Cited by 21 publications

(16 citation statements)

References 93 publications

(104 reference statements)

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“…In a recent review by Lagunas-Rangel, the authors pose the question "Can Exposure to Environmental Pollutants Be Associated with Less Effective Chemotherapy in Cancer Patients?" The authors summarize evidence which strongly supports this hypothesis, which includes toxins which activate AhR (Lagunas-Rangel et al, 2022). Therachiyil examines this from the perspective of gynecological cancers.…”

Section: The Intersection Between Environmental Exposure and Cancer S...mentioning

confidence: 95%

Environmental exposure and the role of AhR in the tumor microenvironment of breast cancer

2022

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Activation of the aryl hydrocarbon receptor (AhR) through environmental exposure to chemicals including polycyclic aromatic hydrocarbons (PAHs) and polychlorinated dibenzo-p-dioxins (PCDDs) can lead to severe adverse health effects and increase the risk of breast cancer. This review considers several mechanisms which link the tumor promoting effects of environmental pollutants with the AhR signaling pathway, contributing to the development and progression of breast cancer. We explore AhR’s function in shaping the tumor microenvironment, modifying immune tolerance, and regulating cancer stemness, driving breast cancer chemoresistance and metastasis. The complexity of AhR, with evidence for both oncogenic and tumor suppressor roles is discussed. We propose that AhR functions as a “molecular bridge”, linking disproportionate toxin exposure and policies which underlie environmental injustice with tumor cell behaviors which drive poor patient outcomes.

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Section: The Intersection Between Environmental Exposure and Cancer S...mentioning

confidence: 95%

Environmental exposure and the role of AhR in the tumor microenvironment of breast cancer

2022

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“…Several studies have shown that environmental pollutants affect cancer development and progression and these have been featured in various reviews (Boffetta, 2006 ; Brody et al., 2007 ; Koual et al., 2020 ; Lagunas‐Rangel et al., 2022 ; Wahlang, 2018 ). For example, some environmental pollutants can promote sustained growth by affecting the cell cycle or prevent apoptosis by avoiding activation of the intrinsic and/or extrinsic pathways.…”

Section: Mechanisms Linked To Carcinogenesis By Environmental Pollutantsmentioning

confidence: 99%

“…A growing body of epidemiological evidence as well as a better understanding of the mechanisms that link toxic substances to disease development suggests that exposure to some environmental pollutants may lead to an increased risk cancer development (Goodson et al., 2015 ; Koual et al., 2020 ). Several studies have raised the role of exposure to low doses of environmental pollutants in cancer initiation as well as cancer progression, suggesting that these compounds may promote cancer invasion and metastasis (Goodson et al., 2015 ; Koual et al., 2020 ; Lagunas‐Rangel et al., 2022 ; Ochieng et al., 2015 ).…”

Section: Introductionmentioning

confidence: 99%

Role of the Synergistic Interactions of Environmental Pollutants in the Development of Cancer

et al. 2022

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Humanity has altered the planet in multiple ways. Global warming; biodiversity loss; and pollution of land, water, and air are just a few of the myriad human-caused environmental problems (T. A. Burke et al., 2017). However, these problems have also had an impact on humanity itself, including an increase in health problems related to poor environmental and earth conditions (Martin et al., 2009). Environmental pollutants are compounds that have been released into the ecosystem and can pose a serious threat to the well-being of living things. These compounds have been suggested to be responsible for approximately 9 million deaths per year, which correspond to 16% of all deaths worldwide. Indeed, three times more deaths than AIDS, tuberculosis, and malaria combined (Landrigan et al., 2018). Because of the notable adverse effects in different areas of our lives, it has been suggested that pollution research has not received enough attention by international development and global health programs, and that the effects of environmental pollutants on health are underestimated in the calculations of the global burden of disease (Landrigan et al., 2019). Furthermore, joint exposure to various environmental pollutants is almost always overlooked in the regulatory framework and a harmonized and consistent approach to conducting mixture risk assessments and management is lacking (Bopp et al., 2018).

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“…Particularly, basal-like carcinomas, also known as triple-negative breast cancers (TNBC), are highly aggressive and metastasizing subtypes, with limited effective treatment strategies [ 105 , 106 ]. This scenario can be exacerbated by exposure to environmental pollution, which was reported to promote the metastasizing power and chemoresistance of different cancer cells [ 9 , 107 , 108 , 109 , 110 ]. In particular, smoking habits have been associated with an increased risk of mortality in breast cancer patients, probably due to a lower chemotherapy susceptibility and chemoresistance development [ 111 , 112 , 113 ].…”

Section: Strengths Limits and Future Perspectivesmentioning

confidence: 99%

“…Increasing epidemiological evidence has highlighted that the exposure to environmental pollution can increase the risk of various diseases, including cancer [ 1 , 2 , 3 , 4 , 5 , 6 ]; additionally, low-level pollutants have been shown to trigger cancer initiation and progression, and to promote tissue invasion, metastasis and chemoresistance [ 7 , 8 , 9 ]. Among the environmental toxicants, cigarette smoke (CS), both active and passive, is known to act as a promoting factor for the incidence of breast cancer, its aggressiveness, and recurrence [ 10 , 11 , 12 , 13 , 14 , 15 ].…”

Section: Introductionmentioning

confidence: 99%

β-Caryophyllene Counteracts Chemoresistance Induced by Cigarette Smoke in Triple-Negative Breast Cancer MDA-MB-468 Cells

et al. 2022

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Exposure to cigarette smoke (CS) has been associated with an increased risk of fatal breast cancers and recurrence, along with chemoresistance and chemotherapy impairment. This strengthens the interest in chemopreventive agents to be exploited both in healthy and oncological subjects to prevent or repair CS damage. In the present study, we evaluated the chemopreventive properties of the natural sesquiterpene β-caryophyllene towards the damage induced by cigarette smoke condensate (CSC) in triple negative breast cancer MDA-MB-468 cells. Particularly, we assessed the ability of the sesquiterpene to interfere with the mechanisms exploited by CSC to promote cell survival and chemoresistance, including genomic instability, cell cycle progress, autophagy/apoptosis, cell migration and related pathways. β-Caryophyllene was found to be able to increase the CSC-induced death of MDA-MB-468 cells, likely triggering oxidative stress, cell cycle arrest and apoptosis; moreover, it hindered cell recovery, autophagy activation and cell migration; at last, a marked inhibition of the signal transducer and activator of transcription 3 (STAT3) activation was highlighted: this could represent a key mechanism of the chemoprevention by β-caryophyllene. Although further studies are required to confirm the in vivo efficacy of β-caryophyllene, the present results suggest a novel strategy to reduce the harmful effect of smoke in cancer patients and to improve the survival expectations in breast cancer women.

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Can Exposure to Environmental Pollutants Be Associated with Less Effective Chemotherapy in Cancer Patients?

Cited by 21 publications

References 93 publications

Environmental exposure and the role of AhR in the tumor microenvironment of breast cancer

Environmental exposure and the role of AhR in the tumor microenvironment of breast cancer

Role of the Synergistic Interactions of Environmental Pollutants in the Development of Cancer

β-Caryophyllene Counteracts Chemoresistance Induced by Cigarette Smoke in Triple-Negative Breast Cancer MDA-MB-468 Cells

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