Can exhaled volatile organic compounds predict asthma exacerbations in children?

Vliet, Dillys van; Smolinska, Agnieszka; Jöbsis, Quirijn; Rosias, Philippe; Muris, Jean; Dallinga, Jan W.; Dompeling, Edward; Schooten, Frederik‐Jan van

doi:10.1088/1752-7163/aa5a8b

Cited by 60 publications

(75 citation statements)

References 34 publications

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“…However, the analysis of panels of breath molecules is still in its infancy and limited to discovery phase research. 166,[257][258][259][260][261][262][263] Beside the measurement of FeNO some work has been done in healthy children using sSIFT-MS. Several metabolites could be measured in a study of 200 healhy children. For some levels were lower than previously found in adults including aceton, ammonia, methanol and isoprene.…”

Section: Promise For Infants and Childrenmentioning

confidence: 99%

On-Line Analysis of Exhaled Breath

et al. 2019

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On-line analysis of exhaled breath offers insight into a person's metabolism without the need for sample preparation or sample collection. Due to its non-invasive nature and the possibility to sample continuously, the analysis of breath has great clinical potential. The unique features of this technology make it an attractive candidate for applications in medicine, beyond the task of diagnosis. We review the current methodologies for on-line breath analysis, discuss current and future applications, and critically evaluate challenges and pitfalls such as the need for standardization. Special emphasis is given to use of the technology in diagnosing respiratory diseases, potential niche applications, and the promise of breath analysis for personalized medicine. The analytical methodologies used range from very small and low-cost chemical sensors, which are ideal for continuous monitoring of disease status, to optical spectroscopy and state-of-the-art, high-resolution mass spectrometry. The latter can be utilized for untargeted analysis of exhaled breath, with the capability to identify hitherto unknown molecules. The interpretation of the resulting big data sets is complex and often constrained due to a limited number of participants. Even larger data sets will be needed for assessing reproducibility and for validation of biomarker candidates. In addition, molecular structures and quantification of compounds are generally not easily available from on-line measurements and require complementary measurements, for example, a separation method coupled to mass spectrometry. Furthermore, lack of standardization still hampers using the technique for screening larger cohorts of patients. The present review summarizes the present status and continuous improvements of the main on-line breath analysis methods, and evaluates obstacles for its wider application.

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Section: Promise For Infants and Childrenmentioning

confidence: 99%

On-Line Analysis of Exhaled Breath

et al. 2019

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“…Pre-school children with acute respiratory wheeze have a different VOC profile compared to children with no wheezing, and such profile remains altered even after symptoms resolution in children with rhinovirus-induced wheeze [ 88 ]. Furthermore, in preschool-age children with recurrent wheezing, VOC profiles could discriminate between children with preclinical asthma and those with a transient form of wheezing, significantly improving on the prediction based on clinical data alone [ 89 , 90 ].…”

Section: Volatile Organic Compounds (Vocs)mentioning

confidence: 99%

Exhaled biomarkers in childhood asthma: old and new approaches

Ferraro

Carraro

Bozzetto

et al. 2018

asthma res and pract

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BackgroundAsthma is a chronic condition usually characterized by underlying inflammation. The study of asthmatic inflammation is of the utmost importance for both diagnostic and monitoring purposes. The gold standard for investigating airway inflammation is bronchoscopy, with bronchoalveolar lavage and bronchial biopsy, but the invasiveness of such procedures limits their use in children. For this reason, in the last decades there has been a growing interest for the development of noninvasive methods.Main bodyIn the present review, we describe the most important non-invasive methods for the study of airway inflammation in children, focusing on the measure of the fractional exhaled nitric oxide (feNO), on the measure of the exhaled breath temperature (EBT) and on the analysis of both exhaled breath condensate (EBC) and exhaled air (Volatile Organic Compounds, VOCs), using targeted and untargeted approaches. We summarize what is currently known on the topic of exhaled biomarkers in childhood asthma, with a special emphasis on emerging approaches, underlining the role of exhaled biomarkers in the diagnosis, management and treatment of asthma, and their potential for the development of personalized treatments.ConclusionAmong non-invasive methods to study asthma, exhaled breath analysis remains one of the most interesting approaches, feNO and “-omic” sciences seem promising for the purpose of characterizing biomarkers of this disease.

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“…Six of them were identified. 39 Although both studies report hydrocarbons as predictive VOCs regarding asthma exacerbations, the identity of the compounds differ between the studies which is a general issue regarding breathomics in pediatric asthma.…”

Section: Vocs In Pediatric Asthmamentioning

confidence: 99%

Breathomics from exhaled volatile organic compounds in pediatric asthma

Neerincx

Vijverberg

Bos

et al. 2017

Pediatric Pulmonology

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Asthma is the most common chronic disease in children, and is characterized by airway inflammation, bronchial hyperresponsiveness, and airflow obstruction. Asthma diagnosis, phenotyping, and monitoring are still challenging with currently available methods, such as spirometry, F NO or sputum analysis. The analysis of volatile organic compounds (VOCs) in exhaled breath could be an interesting non-invasive approach, but has not yet reached clinical practice. This review describes the current status of breath analysis in the diagnosis and monitoring of pediatric asthma. Furthermore, features of an ideal breath test, different breath analysis techniques, and important methodological issues are discussed. Although only a (small) number of studies have been performed in pediatric asthma, of which the majority is focusing on asthma diagnosis, these studies show moderate to good prediction accuracy (80-100%, with models including 6-28 VOCs), thereby qualifying breathomics for future application. However, standardization of procedures, longitudinal studies, as well as external validation are needed in order to further develop breathomics into clinical tools. Such a non-invasive tool may be the next step toward stratified and personalized medicine in pediatric respiratory disease.

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Can exhaled volatile organic compounds predict asthma exacerbations in children?

Abstract: VOCs in exhaled breath showed potential for predicting asthma exacerbations in children within 14 days after sampling. Before using this in clinical practice, the validity of predicting asthma exacerbations should be studied in a larger cohort.

Cited by 60 publications

References 34 publications

On-Line Analysis of Exhaled Breath

On-Line Analysis of Exhaled Breath

Exhaled biomarkers in childhood asthma: old and new approaches

Breathomics from exhaled volatile organic compounds in pediatric asthma

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