Can ethanol be used as an adjuvant to extended curettage in order to reduce the recurrence rate of aneurysmal bone cyst?

Abstract

ObjectiveThe best treatment of aneurysmal bone cyst (ABC) is still unclear. This study aimed to evaluate the usefulness of extended curettage and ethanol as an adjuvant to reduce local recurrence of ABCs.MethodsRetrospectively, 68 cases treated for primary and secondary ABCs caused by benign tumors from 2003 to 2013 were enrolled to a follow-up visit between one to ten years after the surgery. The treatment protocol was en-bloc resection, biopsy and curettage, extended curettage consisted of curettage, high-speed burring, ethanol 96%, and electrocauterization (combined four-step alcohol-using approach) followed by defect filling, consecutively.ResultsAmong 36 patients with primary ABCs (16 male, 20 female, mean age of 16 years, range 3–46 years), 29 cases were treated with the combined four-step alcohol-using approach, four patients with resection, and three with biopsy and curettage. Thirty-two cases had secondary ABCs on benign lesions (17 male, 15 female). The recurrence rate was 5.88 in all primary and secondary ABC cases; two recurrences among 29 patients with primary ABCs (6.9%) and one recurrence among the 22 cases with secondary ABCs (4.5%).ConclusionsIt could be suggested that the combined four-step alcohol-using approach may result in a very low recurrence rate of primary and secondary ABC lesions.

Osteofibrous dysplasia arising in the humerus: A case report

“…Recently, the safety and effectiveness of anhydrous ethanol for adjuvant therapy after intraregional curettage of bone tumor has been reported. 18–20 In a locally aggressive tumor, Oh et al 18 and Solooki et al 19 reported that anhydrous ethanol treatment after curettage reduced local recurrence rate in giant cell tumor and aneurysmal bone tumor, respectively. In benign tumors, Cha et al 20 reported the efficacy of anhydrous ethanol for the treatment of enchondroma.…”

Effect of Ethanol as an Adjuvant to Extended Curettage on Recurrence Rate of Unicameral Bone Cyst

“…[18] Moreover, the efficacy of ethanol to reduce recurrence rate after treatment of giant cell tumor, aneurysmal bone cyst, osteoid osteoma, skeletal metastasis, and other bone lesions has been described in the literature. [10,[19][20][21][22] To the best of our knowledge, the efficacy of ethanol as an adjuvant therapy in UBC lesions has not been described yet. In our study, we evaluated healing and recurrence rate of UBC lesions after ethanol usage as an adjuvant with curettage and bone grafting.…”

“…Definite treatment of UBC lesions was conducted using our approach, called the combined four-step alcohol-using approach, consisted of extended curettage, high-speed burring, ethanol 96%, and electrocauterization of the lesion, consecutively. [10] Extended curettage was performed to remove all abnormal tissues. After using high-speed burr on the walls of the lesion, the defect was irrigated by normal saline.…”

Recurrent aneurysmal bone cyst of talus resulted in tibiotalocalcaneal arthrodesis

“…ABC is a benign tumoral condition peaking at the first two decades of life[ 1 ]. Although different treatment options are available, commonly surgical treatment of ABCs including curettage with or without bone grafting in addition to different adjuvants or wide en-bloc resection of tumor is preferred[ 6 , 9 - 11 ]. Although the presented case was initially treated using curettage and bone grafting, recurrence was seen after 8 mo following the primary surgery.…”