Can electrodynamic interaction between a molecule and metal dominate a continuum background in surface-enhanced Raman scattering?

Dvoynenko, Mykhaylo M.; Wang, Juen-Kai

doi:10.1039/c5cp04633e

Cited by 7 publications

(7 citation statements)

References 46 publications

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“…The success of the SERS-AST method relies on our previous efforts in developing the SERS detection platform: (1) the development of uniform and reliable SERS-active substrate based on 2-dimension Ag nanoparticle array embedded in nanochannels of anodic alumina 44 , (2) the experimental and theoretical investigations of its anomalous optical propensity [59][60][61] , and (3) the fundamental understanding of SERS mechanisms [61][62][63][64] . There are several points that are relevant to the SERS-AST method and worthy of special attention.…”

Section: Concordant 15 32mentioning

confidence: 99%

Rapid antibiotic susceptibility testing of bacteria from patients’ blood via assaying bacterial metabolic response with surface-enhanced Raman spectroscopy

Han

Lin

Cheng

et al. 2020

Sci Rep

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Blood stream infection is one of the major public health issues characterized with high cost and high mortality. Timely effective antibiotics usage to control infection is crucial for patients' survival. The standard microbiological diagnosis of infection however can last days. the delay in accurate antibiotic therapy would lead to not only poor clinical outcomes, but also to a rise in antibiotic resistance due to widespread use of empirical broad-spectrum antibiotics. An important measure to tackle this problem is fast determination of bacterial antibiotic susceptibility to optimize antibiotic treatment. We show that a protocol based on surface-enhanced Raman spectroscopy can obtain consistent antibiotic susceptibility test results from clinical blood-culture samples within four hours. the characteristic spectral signatures of the obtained spectra of Staphylococcus aureus and Escherichia coli-prototypic Gram-positive and Gram-negative bacteria-became prominent after an effective pretreatment procedure removed strong interferences from blood constituents. Using them as the biomarkers of bacterial metabolic responses to antibiotics, the protocol reported the susceptibility profiles of tested drugs against these two bacteria acquired from patients' blood with high specificity, sensitivity and speed. Blood stream infection (BSI)-defined as the presence of viable bacteria in blood (i.e., bacteremia) documented by a positive blood culture result 1-arouses morbidity and mortality worldwide 2. It is the primary cause of sepsis, which is a major public health concern with particular high medical cost 3,4. Although the number of BSI incidence bears demographic difference, it shows increasing trend over time 5,6 and therefore remains an urgent medical challenge. Timely administration of appropriate antibiotic therapy is critical to avoiding its progression. A retrospective analysis study based on a large dataset showed that there was a linear increase in the risk of mortality for each hour delay in antibiotic administration 7 , which was confirmed by a recent study 8. However, owing to lack of timely microbiological evidence, antibiotics are usually forced to start empirically, rather than precisely upon specific target(s) 9. Improper antibiotic selection was not uncommon and the mortality markedly increased 10. Moreover, the initial empirical use of broad-spectrum antibiotics 11 , although prudent, inevitably

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Section: Concordant 15 32mentioning

confidence: 99%

Rapid antibiotic susceptibility testing of bacteria from patients’ blood via assaying bacterial metabolic response with surface-enhanced Raman spectroscopy

Han

Lin

Cheng

et al. 2020

Sci Rep

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“…Indeed, it has been noted in [8,33] that at very small distances between the dipole and sphere surface as compared to the sphere radius, the sphere can be considered as a flat substrate from the point of view of the reflected part of the Green function. In other words, the well-known electrostatic approximation [1,20] may be applied in this case. The nonlocality of the metal response reduces the Q-factor of the resonance, but its peak is still nearby this wavelength.…”

Section: Resultsmentioning

confidence: 99%

“…Since the dipole moment is in inverse proportion to [18,19], the emitted intensity I can be written as [14,20] ( ) parts of the Green tensor are responsible for the transformation from the near-field zone to the far-field zone. The spectrum depends mainly on the denominator, but is slightly modified by the nominator.…”

Section: Fluorescence Of An Emitter Near Metalmentioning

confidence: 99%

Fluorescence of molecules placed near a spherical particle: Rabi splitting

Dvoynenko¹

2017

Semicond. Phys. Quantum Electron. Optoelectron.

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Abstract. Theoretical study of spontaneously emitted spectra of point-like source placed near spherical Ag particle was performed. It was shown that near-field electromagnetic interaction between a point-like emitter and spherical Ag particle leads to strong coupling between them at very small emitter-metal surface distances. It was shown that values of Rabi splitting are quantitatively close to that of emitter-flat substrate interaction.

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“…The inevitable SERS continuum background , of each measured SERS spectrum was removed by the following two steps. The first step is to subtract the measured SERS spectrum of a nearby droplet of aqueous solution with a designated pH value from that of the Cr sample with the same pH value, removing the major portion of the background.…”

Section: Methodsmentioning

confidence: 99%

Speciation Analysis of Cr(VI) and Cr(III) in Water with Surface-Enhanced Raman Spectroscopy

Dvoynenko

Chen

et al. 2021

ACS Omega

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Identifying and quantifying chromium in water are important for the protection of precious water resources from chromium pollution. Standard methods however are unable to easily distinguish toxic hexavalent chromium, Cr(VI), from innocuous trivalent chromium, Cr(III), are time-consuming, or require large sample quantity. We show in this report that Cr(VI) and Cr(III) in water can be differentiated based on their distinct spectral features of surface-enhanced Raman scattering (SERS). Their SERS signals exhibit different pH dependences: the SERS features of Cr(VI) and Cr(III) are most prominent at pH values of 10 and 5.5, respectively. The obtained limit of detection of Cr(VI) in water is below 0.1 mg/L. Both concentration curves of their SERS signals show Langmuir sorption isotherm behavior. A procedure was developed to quantify Cr(VI) concentration based on the direct retrieval or addition method with an error of 10%. Finally, the SERS detection of Cr(VI) is shown to be insensitive to co-present Cr(III). The developed SERS procedure offers potential to monitor toxic chromium in fields.

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Can electrodynamic interaction between a molecule and metal dominate a continuum background in surface-enhanced Raman scattering?

Cited by 7 publications

References 46 publications

Rapid antibiotic susceptibility testing of bacteria from patients’ blood via assaying bacterial metabolic response with surface-enhanced Raman spectroscopy

Rapid antibiotic susceptibility testing of bacteria from patients’ blood via assaying bacterial metabolic response with surface-enhanced Raman spectroscopy

Fluorescence of molecules placed near a spherical particle: Rabi splitting

Speciation Analysis of Cr(VI) and Cr(III) in Water with Surface-Enhanced Raman Spectroscopy

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