Can DWI &amp; ADC differentiate orbital lymphoma, non-specific orbital inflammation and orbital cellulitis?

Ragheb, Ahmad S.; El-Rahman, Hossam Mansour Abd; Khattab, Hatem Amin

doi:10.1016/j.ejrnm.2012.02.005

Cited by 2 publications

(2 citation statements)

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“…Some of the earlier studies have suggested that DWI has a role in the prediction of malignancy in orbital masses, differentiation of orbital lymphoma from pseudotumors, evaluation of orbital cellulitis, identification of orbital abscess, and assessment of optic nerve lesions and infa rct. 8,17,[19][20][21][22] To the best of our knowledge, this is the first study evaluating the role of DWI and ADC values in orbital mass lesions among the Indian population. In our study, a total of 44 patients clinically suspected of having an orbital mass lesion underwent conventional MRI along with DWI with an aim of evaluating the role of DWI and ADC values in differentiating benign and malignant orbital lesions.…”

Section: Discussionmentioning

confidence: 94%

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Role of Quantitative Diffusion-Weighted Imaging in Differentiating Benign and Malignant Orbital Masses

Mundhada¹,

Rawat

Acharya

et al. 2021

Indian Journal of Radiology and Imaging

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Aim To determine the role of diffusion-weighted imaging (DWI) with apparent diffusion coefficient (ADC) values in differentiating benign and malignant orbital masses. Materials and Methods After obtaining institutional ethical board approval and informed consent from all patients, an observational study was done for a period of 24 months in the radiology department of a tertiary care hospital in South India. Conventional magnetic resonance imaging and DWI using a 3T scanner was done for all patients with suspected orbital mass lesion. ADC value and clinicohistopathological correlation were studied for every patient. Chi-square test was used to compare the signal characteristics of DWI and ADC maps between benign and malignant lesions. A comparison of mean ADC values for benign and malignant masses was performed using Student’s t-test for independent samples. The cut-off value for ADC was obtained using the receiver operating characteristic (ROC) curve. Results Of 44 patients with orbital lesions, 70% were benign and 30% were malignant. There was a significant difference in the mean ADC values of benign and malignant orbital masses. Using ROC curve analysis, an optimal ADC threshold of 1.26 × 10−3 mm2/s was calculated for the prediction of malignancy with 100% sensitivity, 80.65% specificity, and 86.36% accuracy (95% confidence interval: 0.872, 1.00, p < 0.0001). Two ADC thresholds were used to characterize the orbital masses with more than 90% confidence. Conclusion Quantitative assessment of ADC is a useful noninvasive diagnostic tool for differentiating benign and malignant orbital masses. Malignant orbital lesions demonstrate significantly lower ADC values as compared with benign lesions.

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