Can “Dor to Dor+Rec Neurorrhaphy” by Biodegradable Chitin Conduit Be A New Method for Peripheral Nerve Injury?

Xi, Yin; Kou, Yu; Wang, Yanhua; Zhang, Peixun; Zhang, Dian Yin; Fu, Zhong Guo; Zhang, Hong Bo; Jiang, Bailin

doi:10.3109/10731199.2010.506851

Cited by 9 publications

(3 citation statements)

References 23 publications

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“…Thinner proximal nerves can be utilized to repair thicker distal damaged nerves. Nerve transposition repair can reduce the denervation of the target organ and promote cost-effective rehabilitation by allowing the donor nerve to generate additional sprouts toward the distal stump, thereby restoring the structure and function of the damaged nerve [ 39 , 40 ]. The distal tibial nerve was repaired using the common peroneal nerve as a donor in this research.…”

Section: Discussionmentioning

confidence: 99%

Chitin Conduits with Different Inner Diameters at Both Ends Combined with Dual Growth Factor Hydrogels Promote Nerve Transposition Repair in Rats

Zhang,

Ma,

et al. 2023

JFB

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Severe peripheral nerve injuries, such as deficits over long distances or proximal nerve trunk injuries, pose complex reconstruction challenges that often result in unfavorable outcomes. Innovative techniques, such as nerve transposition repair with conduit suturing, can be employed to successfully treat severe peripheral nerve damage. However, cylindrical nerve guides are typically unsuitable for nerve transposition repair. Furthermore, angiogenic and neurotrophic factors are necessary to stimulate the emergence of axonal lateral sprouts, proximal growth, and the rehabilitation of neuron structures and functions. In the current study, we used chitosan to make chitin conduits with different inner diameters at both ends, combined with gelatin methacrylate hydrogels that can continuously release dual growth factors, namely, the vascular endothelial growth factor (VEGF) and the nerve growth factor (NGF), and evaluated its impact on nerve transposition repair in rats. At 16 weeks after the operation, our findings showed that the conduit combined with the dual growth factor hydrogel significantly improved the restoration of both motor and conduction functions of the nerve. In addition, histological analysis showed significant recovery of nerve fibers, target muscles, and neurons. In conclusion, the combination of chitin conduits with different inner diameters and dual growth factor hydrogels can significantly improve the effect of nerve transposition repair, which has important potential clinical value.

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Section: Discussionmentioning

confidence: 99%

Chitin Conduits with Different Inner Diameters at Both Ends Combined with Dual Growth Factor Hydrogels Promote Nerve Transposition Repair in Rats

Zhang,

Ma,

et al. 2023

JFB

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“…Although not yet used in clinical practice, these results provide new theoretical guidance for the selection of donors in the treatment of peripheral nerve defects by autologous nerve transplantation [16][17][18][19][20].…”

Section: Discussionmentioning

confidence: 99%

How many nerve fibres can be separated as donor from an integral nerve trunk when reconstructing a peripheral nerve trauma with amplification method by artificial biochitin conduit?

Yin

Zhang

Kou

et al. 2018

Artificial Cells, Nanomedicine, and Biotechnology

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Using portion of a nearby nerve trunk to reconstruct a severe nerve lesion by artificial biodegradable chitin conduit is the core practicable method based on peripheral nerve amplification regeneration. However, the quantitative influences on skeletal muscle function corresponding to the injury of the donated nerve fibres were not previously reported. Here, we aimed to explore the compensative capacity in tibialis anterior muscles of rats with the models of acute tibialis anterior nerve branch injuries. The tibialis anterior branch of deep peroneal nerve was transected in various levels each time. Both the decreased treads of maximal compound muscle action potential (CMAP) amplitude and complete tetanic tension of the tibialis anterior muscle in rats were similar with the increasing numbers of damaged nerve fibres, which showed two S-shaped curves. When the nerve injury level was less than approximately 10%, the skeletal muscle function remained normal through complete compensation of motor endplates. As the injury degree went from 10% to 85%, the muscle function was partially impaired due to the broken compensation of motor endplates. When the nerve injury level was over approximately 85%, the skeletal muscle function was totally lost. It suggests that within a certain level of nerve injury, the skeletal muscle function maintained basically unchanged via complete compensation of motor endplates. Such nerve fibres may be used as donor nerve to repair peripheral nerve injury.

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“…Previous studies have revealed that regeneration and compensation occurs in the regeneration of peripheral nerves (Redett et al ., ; Jiang et al ., ; Wang et al ., ). Furthermore, these studies have provided preliminary evidence for the maturation of sprouting nerve fibres (Redett et al ., ; Yin et al ., ). These findings provide a possible novel strategy for repairing serious damage to proximal nerve stumps through direct anastomosis to smaller number of proximal nerve stumps.…”

Section: Introductionmentioning

confidence: 97%

Motor function recovery during peripheral nerve multiple regeneration

Zhang

Peng

et al. 2013

J Tissue Eng Regen Med

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Neuronal functional compensation and multiple regenerating axon sprouting occur during peripheral nerve regeneration. Sprouting nerve buds were quantitatively maintained and had matured when multiple injured distal nerves were anastomosed to smaller number of proximal nerve stumps; this has positive clinical significance for proximal stump damage. This study investigated whether sprouting axon buds would reinnervate the distal neuromuscular junction and maintain the function of the target organ under compensation conditions. The results showed that the sprouting axon buds maintained the numbers and morphology of motor end plates repaired by a smaller number of proximal nerve stumps, and recovered 80.0% tetanic muscle force compared with the normal side. Meanwhile, nerve conduction velocity, compound muscle action potential and diameter of muscular fibres declined 72.7%, 73.2% and 61.8%, respectively, compared with normal. This observation indicates the potential functional reserve of neurons and that it is feasible to repair nerve fibre injury through anastomosis of multiple distal nerve stumps with a smaller number of proximal nerve stumps, within the limits of compensation.

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Can “Dor to Dor+Rec Neurorrhaphy” by Biodegradable Chitin Conduit Be A New Method for Peripheral Nerve Injury?

Cited by 9 publications

References 23 publications

Chitin Conduits with Different Inner Diameters at Both Ends Combined with Dual Growth Factor Hydrogels Promote Nerve Transposition Repair in Rats

Chitin Conduits with Different Inner Diameters at Both Ends Combined with Dual Growth Factor Hydrogels Promote Nerve Transposition Repair in Rats

How many nerve fibres can be separated as donor from an integral nerve trunk when reconstructing a peripheral nerve trauma with amplification method by artificial biochitin conduit?

Motor function recovery during peripheral nerve multiple regeneration

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