Can deep eutectic solvents be the best alternatives to ionic liquids and organic solvents: A perspective in enzyme catalytic reactions

Nian, Binbin; Li, Xue

doi:10.1016/j.ijbiomac.2022.07.044

Cited by 46 publications

(24 citation statements)

References 106 publications

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“…Structural identification. The structures of the compounds were identified by nuclear magnetic resonance ( 1 H NMR, 13 C NMR), high resolution mass spectrometry (HRMS) and infrared spectroscopy (IR). 1 H NMR and 13 C NMR spectra data were recorded by a BRUKER AVANCE III 400 MHz spectrometer ( 1 H 400 MHz, 13 C 100 MHz).…”

Section: Methodsmentioning

confidence: 99%

“…[8] The enzymes such as lipases and esterases have been reported to catalyze esterification, interesterification, thioesterification and transesterification reactions, which kinetically proceed via the ping-pong biÀ bi mechanism, ternary complex ordered biÀ bi mechanism, or ternary complex random biÀ bi mechanism. [9][10][11][12][13][14][15][16] The commercial immobilized lipase Novozym 435 (N435) is the most commonly used for enzyme-catalyzed transesterification due to the ability to recognize a wide variety of substrates and catalyze most reactions. [17] In addition, the odor characteristics and potentiality of the compounds as flavors or fragrances could be assessed by chromatography-mass spectrometry-olfactometry (GC-MS-O).…”

Section: Introductionmentioning

confidence: 99%

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Enzyme‐Catalyzed Synthesis, Odor Characteristics and Thermal Analysis of New Pyridine Esters

et al. 2023

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A new method for the efficient conversion of pyridine methanols and ethyl carboxylates to pyridine esters in air catalyzed by Novozym 435 (N435) was reported. The enzyme catalyzed transesterification reaction was performed under the optimum conditions: N435 (60 mg) as a biocatalyst, acetonitrile (2.5 mL) as a solvent, the molar ratio of pyridine methanols (0.2 mmol) to ethyl carboxylats (1.0 mmol) of 1 : 5, molecular sieve 3 A of 1.00 g, reaction temperature of 50 °C, the revolution speed of 150 rpm and reaction time of 36 h. The enzyme still retained a yield of 80 % after repeated use for 10 times. Under optimal conditions, eighteen pyridine esters were synthesized in this paper, containing fifteen esters as novel compounds. The synthesized pyridine esters were analyzed by gas chromatography-mass spectrometry-olfactory (GC-MS-O), of which four pyridyl esters including compounds 3 a, 3 c, 3 g and 3 r possessed strong aromas which were based on peak area in GC-MS. Thermogravimetric analysis (TG) was performed on these four flavor compounds. According to the results of TG analysis, they had good thermal stability at the certain temperature.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Enzyme‐Catalyzed Synthesis, Odor Characteristics and Thermal Analysis of New Pyridine Esters

et al. 2023

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“…Traditional methods of extraction include Soxhlet extraction with solvents such as ethanol, methanol, and acetone and extraction with the aid of stirring and heating, commonly used together with the assistance of ultrasound or microwaves. − The application of organic solvents in the extraction processes comes with some disadvantages, such as high flammability, high vapor pressure, and, in some cases, toxicity. , Additionally, some extracted compounds, e.g., anthocyanins, are prone to degradation at high temperatures. Thus, it is even more difficult to efficiently extract them with organic solvents.…”

Section: Effect Of Type Of Des and Process Conditions For Extraction ...mentioning

confidence: 99%

The Most Potent Natural Pharmaceuticals, Cosmetics, and Food Ingredients Isolated from Plants with Deep Eutectic Solvents

Wawoczny

Gillner

2023

J. Agric. Food Chem.

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There is growing interest in reducing the number of synthetic products or additives and replacing them with natural ones. The pharmaceutical, cosmetic, and food industries are especially focused on natural and bioactive chemicals isolated from plants or microorganisms. The main challenge here is to develop efficient and ecological methods for their isolation. According to the strategies and rules of sustainable development and green chemistry, green solvents and environmentally friendly technologies must be used. The application of deep eutectic solvents as efficient and biodegradable solvents seems to be a promising alternative to traditional methods. They are classified as being green and ecological but, most importantly, very efficient extraction media compared to organic solvents. The aim of this review is to present the recent findings on green extraction, as well as the biological activities and the possible applications of natural plant ingredients, namely, phenolics, flavonoids, terpenes, saponins, and some others. This paper thoroughly reviews modern, ecological, and efficient extraction methods with the use of deep eutectic solvents (DESs). The newest findings, as well as the factors influencing the efficiency of extraction, such as water content, and hydrogen bond donor and acceptor types, as well as the extraction systems, are also discussed. New solutions to the major problem of separating DESs from the extract and for solvent recycling are also presented.

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“…As one of the 12 principles of green chemistry, the utilization of renewable feedstock as a succedaneum of the petrochemical base has always been always a key strategy to make a sustainable and green chemistry process in contemporary industries [ 1 , 2 , 3 ]. Moreover, the utilization of natural starting materials as an alternative to primary resources is of growing interesting and has attracted more attention in health-related fields [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

Selective and Efficient Synthesis of Pine Sterol Esters Catalyzed by Deep Eutectic Solvent

Shi

et al. 2023

Molecules

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Phytosterol esters have attracted widespread academic and industrial interests due to their advantages in lowering cholesterol, as antioxidants, and in preventing or treating cancer. However, the generation of by-products limits the application of phytosterol esters in food fields. In this study, deep eutectic solvents (DESs), a series of green, nontoxic, low-cost and biodegradable solvents, were adopted as the catalyst for the synthesis of pine sterol esters. The results showed that the acidic DES which was prepared with choline chloride (ChCl) and p-toluene sulfonic acid monohydrate (PTSA) with a molar ratio of 1:3 performed best in the prescreening experiments. To further improve the efficiency of the pine sterol ester, the molar ratio of substrates, the amount of catalyst, the reaction temperature and the reaction time were optimized, and its yield was improved to 94.1%. Moreover, the by-products of the dehydration side reactions of the sterol can be efficiently inhibited. To make this strategy more universal, other fatty acids were also used as the substrate for the synthesis of pine sterol esters, and a yield of above 92.0% was obtained. In addition, the reusability of DES was also investigated in this study, and the efficiency of DES was well maintained within five recycled uses. Finally, DFT calculations suggested that the suitable H-bonds between ChCl and PTSA decreased the nucleophilic capacity and increased the steric hindrance of the latter, and further prevented the attack on βH and reduced the generation of by-products. This study developed a reliable and eco-friendly strategy for the preparation of high-quality phytosterol esters with low-dosage catalyst usage and high selectivity.

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Can deep eutectic solvents be the best alternatives to ionic liquids and organic solvents: A perspective in enzyme catalytic reactions

Cited by 46 publications

References 106 publications

Enzyme‐Catalyzed Synthesis, Odor Characteristics and Thermal Analysis of New Pyridine Esters

Enzyme‐Catalyzed Synthesis, Odor Characteristics and Thermal Analysis of New Pyridine Esters

The Most Potent Natural Pharmaceuticals, Cosmetics, and Food Ingredients Isolated from Plants with Deep Eutectic Solvents

Selective and Efficient Synthesis of Pine Sterol Esters Catalyzed by Deep Eutectic Solvent

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