Can decreasing smoking prevalence reduce leukemia mortality?

Varadarajan, Ramya; Cummings, Michael H.; Hyland, Andrew; Wang, Eunice S.; Wetzler, Meir

doi:10.1007/s00277-010-0957-6

Cited by 4 publications

(4 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In a study published by our group earlier, 24 we had shown that leukemia mortality has decreased overall in the United States in parallel with decreased smoking. Analyzed on a state-specific basis, leukemia mortality has decreased in states where smoking rates declined markedly but remained unchanged where smoking prevalences were relatively stable suggesting that declining rates of leukemia mortality are associated with changing patterns of smoking behavior.…”

Section: Discussionmentioning

confidence: 88%

Smoking adversely affects survival in acute myeloid leukemia patients

Varadarajan

Licht

Hyland

et al. 2011

Intl Journal of Cancer

Self Cite

View full text Add to dashboard Cite

Summary Smoking adversely affects hematopoietic stem cell transplantation outcome. We asked whether smoking affected outcome of newly diagnosed acute myeloid leukemia (AML) patients treated with chemotherapy. Data were collected on 280 AML patients treated with high-dose cytarabine and idarubicin-containing regimens at Roswell Park Cancer Institute who had smoking status data at diagnosis. Patients’ gender, age, AML presentation (de novo vs. secondary), white blood cell (WBC) count at diagnosis, karyotype and smoking status (never vs. ever) were analyzed. Among the 161 males and 119 females with a median follow-up of 12.9 months, 101 (36.1%) had never smoked and 179 (63.9%) were ever smokers. The proportion of patients between never and ever smokers was similar with respect to age, AML presentation, WBC count at diagnosis or karyotype based on univariate analysis of these categorical variables. Never smokers had a significantly longer overall survival (60.32 months) compared to ever smokers (30.89; p=0.005). In multivariate analysis incorporating gender, age, AML presentation, WBC count, karyotype, and smoking status as covariates, age, karyotype and smoking status retained prognostic value for overall survival. In summary, cigarette smoking has a deleterious effect on overall survival in AML.

show abstract

Section: Discussionmentioning

confidence: 88%

Smoking adversely affects survival in acute myeloid leukemia patients

Varadarajan

Licht

Hyland

et al. 2011

Intl Journal of Cancer

Self Cite

View full text Add to dashboard Cite

show abstract

“…28 In addition, a national study in the United States found that leukemia deaths decreased in states where smoking rates decreased but remained unchanged in states where smoking prevalence remained relatively constant. 29 In a study in Europe, it was shown that the trend of mortality due to leukemia from the years 1970 to 2009 decreased in most European countries, and the age group of 0-14 witnessed the most significant decrease (AAPC = -3.7%) for men and (-3.8%) women. Also, in the age group of 15-44 years, AAPC was -2% for both sexes.…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Trend Analysis of Leukemia Mortality and Years of Life Lost (YLL) from 2004 to 2019 in the Fars Province, Iran

Azarbakhsh,

Rezaei,

Hassanzadeh

et al. 2023

Arch Iran Med

View full text Add to dashboard Cite

Background: Although the incidence of leukemia’s is not high, many of these cancers lead to death over a short period. This is a cross-sectional study on leukemia deaths in southern Iran. Methods: All deaths due to leukemia in the Fars province were obtained from the population-based electronic death registration system (EDRS). Crude and age-standardized mortality rate (ASMR), YLL, and YLL rate data were calculated, and joinpoint regression was used to examine the trend. Results: Totally, 3141 deaths from leukemia occurred in the Fars province during the study period (2004-2019). Of these, 61.5% (1933 cases) pertained to men. The crude mortality rate was 6.1 (95% CI: 5.8 to 6.4) in men and 3.9 (95% CI: 3.7 to 4.2) in women. Also, ASMR was 6.6 (95% CI: 6.3 to 6.9) and 4.2 (95% CI: 4.0 to 4.4) in men and women, respectively. The total YLLs due to leukemia were 32804 in men and 23064 in women. The joinpoint regression analysis demonstrated that the trend of YLL rate due to premature mortality was stable: the annual percent change (APC) was -1.2% (95% CI: -2.5 to 0.2, P=0.090) for males, and -1.0% (95% CI: -2.9 to 0.9, P=0.274) for females. Conclusion: The mortality and YLL due to leukemia had a stable trend. However, this trend has been decreasing or increasing in some age groups. Determining and controlling essential risk factors, especially the environmental factors of leukemia, may reduce its burden in the Fars province.

show abstract

“…However, it is the seventh cause of YLL due to premature death in the world (Fitzmaurice et al, 2015). Increased incidence of leukemia is attributable to risk factors such as obesity and smoking (Varadarajan et al, 2010;Chu et al, 2011) both being common risk factors in Yazd (Namayandeh et al, 2011), although further analysis is required to identify other risk factors in the region.…”

Section: Discussionmentioning

confidence: 99%

Expected Years of Life Lost Due to Adult Cancer Mortality in Yazd (2004-2010)

Mehrara¹,

Mirzadeh²,

Mirzaei³

2016

Asian Pacific Journal of Cancer Prevention

View full text Add to dashboard Cite

Despite achievements in controlling and preventing infectious diseases in recent decades, the incidence of chronic diseases, especially cancer, follows an increasing trend due to aging of populations, changes in lifestyle, increased smoking, immobility, and poor diet, which will double the burden of the disease (Etemadi et al., 2008;Thun et al., 2010;Keyghobadi et al., 2015;Zahedi et al., 2015). Therefore, studies on the incidence of cancer and cancer-induced mortalities in different geographical areas with different cultures can help in identification of factors affecting the incidence of cancer.A total of 14.9 million new cases and 8.2 million deaths from cancer occurred in 2013, and 196.3 million Disability-Adjusted Life Year (DALY) of people's life was lost. Developing countries contribute to 62% of cancer-induced mortalities and 70% of years of life lost (YLL) (Lozano et al., 2012;Fitzmaurice et al., 2015). Cancer is the second and the third cause of death in developed countries and the world, respectively. Despite improved preventive measures and the development of diagnostic and therapeutic procedures, it has rised by more AbstractThe number of deaths is often measured to monitor the population health status and priority of health problems. However, number of years of life lost (YLL) is a more appropriate indicator in some cases. We have calculated the YLL of adult cancers and its trend over the past few years in Yazd to provide planners with baseline data. Data obtained from death registration system were used to calculate the YLL, based on each individual's age at death, and the standardized expected YLL method was applied with a discount rate of 0.03, an age weight of 0.04, and a correction factor of 0.165. All data were analyzed and prepared in Epi6 and Excel 2007. A total of 3,850 death records were analyzed. Some 550 patients in Yazd province aged ≥20 die annually due to cancer (male: female ratio 1.3). The average ages at death in lung, CNS, breast cancer and leukemia cases were 68.5, 59, 58.7 and 61, respectively. The age group of 40-59 with 21 % had the highest cancer mortality percentage. Premature cancer deaths have caused 40,753 YLL (5,823 YLL annually). Females lose on average more life years to cancer than do men (11.6 vs 9.8 years). Lung cancer (12.1%), CNS tumors (11.7%) and leukemia (11.4 %) were the leading causes terms of YLL due to all cancers in both sexes. From 2004 to 2010, cancer-caused YLL as a fraction of all YLL increased from 12.8 to 15.2 %. This study can help in the assessment of health care needs and prioritization. Cancer is the major cause of deaths and the trend is increasing. The use of YLLs is a better index for measurement of premature mortality for ranking of diseases than is death counts. Longer periods of observation will make these trends more robust and will help to evaluate and develop, better public health interventions.

show abstract

Can decreasing smoking prevalence reduce leukemia mortality?

Cited by 4 publications

References 13 publications

Smoking adversely affects survival in acute myeloid leukemia patients

Smoking adversely affects survival in acute myeloid leukemia patients

Trend Analysis of Leukemia Mortality and Years of Life Lost (YLL) from 2004 to 2019 in the Fars Province, Iran

Expected Years of Life Lost Due to Adult Cancer Mortality in Yazd (2004-2010)

Contact Info

Product

Resources

About