Can Coronavirus Disease 2019 Induce Sarcoidosis: A Case Report

Abstract

Since the emergence of coronavirus disease 2019, a large spectrum of clinical manifestations following this acute viral infection has been reported especially autoimmune manifestations and inflammatory disorders. However, a causal link has not yet been established. Herein, we reported a case of pulmonary mediastinal sarcoidosis following coronavirus disease 2019 infection. A 41-year-old woman with no clinical or radiographic symptoms or signs of sarcoidosis prior to coronavirus disease 2019 infection developed dyspnea, cough, and fatigue, a few months after discharge. A chest thoracic scan performed 3 months after hospital discharge showed regression of ground-glass opacities with the appearance of pulmonary micronodules. Clinical examination and spirometry were normal. The evolution was marked by progressive worsening of dyspnea and significant weight loss. A chest thoracic scan performed 6 months after discharge showed bilateral and symmetrical hilar and mediastinal and paratracheal lymphadenopathy. Bronchoalveolar lavage with cell count showed a lymphocytosis of 19.5% and a CD4/CD8 T cell ratio of 2.2. Endobronchial lung biopsy revealed noncaseating epithelioid granulomas. Sputum culture excluded tuberculosis. The diagnosis of pulmonary-mediastinal sarcoidosis was made. She was treated with an oral corticosteroid. The patient showed significant improvement during the 3-month follow-up period. Post-coronavirus disease sarcoidosis is very rare. Complementary studies are needed to discern the link between these diseases.

Sarcoidosis detected after COVID‑19 with T‑SPOT.TB positive: A case report

“…Although sarcoidosis developing after COVID-19 has been reported previously ( 32 ), the patient in the present case had a unique clinical performance other than the typical respiratory symptoms. In addition, the patient was tested T-SPOT.TB-positive, which necessitated additional procedures in delineating the diagnosis from active tuberculosis.…”

Post-COVID-19 Granulomatous Inflammation in the Lung, Distinct From Sarcoidosis: A Report of Two Cases

“…A recent study reported an increased risk of sarcoidosis following COVID-19. Additionally, there have been several case reports of pulmonary sarcoidosis occurring several weeks to months after COVID-19 [4][5][6][7][8].…”