Can conjunctival lymphoma be a clinical diagnosis?

Coupland, Sarah E.; Heegaard, Steffen

doi:10.1136/bjophthalmol-2013-304309

Cited by 4 publications

(5 citation statements)

References 15 publications

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“…However, when a physician encounters less common histologic types of lymphoma in this anatomical site, difficulties in their recognition and management may arise [ 5 ]. Besides, the usual clinical appearance of a benign lymphoid hyperplasia or a malignant lymphoma is normally a ‘salmon patch’-like conjunctival swelling, without any specific clinical signs that can aid with the differentiation between the 2 lesions [ 6 ].…”

Section: Discussionmentioning

confidence: 99%

Conjunctival Follicular Lymphoma after Treatment for Invasive Squamous Cell Carcinoma

Cunha

Barros

Motono

et al. 2014

Case Rep Ophthalmol

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Backgrounds/Aims: The authors describe the case of a 79-year-old Caucasian woman who presented an ocular adnexal lesion as the first clinical manifestation of a systemic follicular lymphoma, highlighting the clinicopathological features of this rare entity and its potential to be misdiagnosed as marginal zone lymphoma of the mucosa-associated lymphoid tissue. Methods: Conjunctival impression cytology was performed for a rapid initial diagnosis of lymphoma, and subsequent histopathological and immunohistochemical studies were carried out for its confirmation and to identify the best therapeutic regimen. Results: After the initial presentation and diagnosis, she was submitted to complete clinical evaluation; confluent retroperitoneal lymphadenopathy was detected through abdominal computed tomography, characterizing clinical stage III. Conclusion: Awareness of this lymphoma is important when making a diagnosis of ocular adnexal lymphoid neoplasms for its appropriate evaluation and management.

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Section: Discussionmentioning

confidence: 99%

Conjunctival Follicular Lymphoma after Treatment for Invasive Squamous Cell Carcinoma

Cunha

Barros

Motono

et al. 2014

Case Rep Ophthalmol

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“…The conventional and currently standard treatment for conjunctival MALT lymphoma is external beam radiation therapy, which achieves complete remission exceeding 90% [3,9]. Other treatments, including excision only, excision and topical chemotherapy, and intralesional chemotherapy, have also been reported to achieve complete remission [10][11]. In the present case, we chose surgical resection of the lesions combined with cryosurgery.…”

Section: Discussionmentioning

confidence: 99%

A case of palpebral conjunctival MALT lymphoma misdiagnosed as giant papillary conjunctivitis

Liao

Zheng

Lu³

et al. 2019

Preprint

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Background Although conjunctival lymphoma is generally easy to diagnose, misdiagnosis of this condition has been repeatedly reported. This article presents a rare case of lymphoma arising from the palpebral conjunctiva in a very young woman whose disease was initially misdiagnosed as giant papillary conjunctivitis. Case presentation A 20-year-old young woman with a history of chronic rhinitis presented with bilateral, salmon-pink, multiple-nodular patches in both the superior and inferior palpebral conjunctivae. The patient did not respond to hormone (glucocorticoids) and other anti-inflammatory medications. Therefore, she underwent surgical resection combined with cryosurgery and achieved complete remission. According to histopathology and immunohistochemistry examinations, a diagnosis of extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT) was made. Two months post-treatment, she received additional radiation therapy because a sign of recurrence was apparent. From then, she had no recurrence, vision loss, or cataract during a follow-up of six months. Conclusions Although the diagnosis of conjunctival MALT lymphoma is straightforward in most cases due to its characteristic salmon-like appearance, misdiagnosis of this condition can occur. When conventional antibiotic and anti-inflammatory treatments are not effective, conjunctival lymphoma should be considered and biopsy for histological and immunohistochemical analyses is warranted. The combination of excision, cryosurgery and radiation therapy is an effective approach to achieve complete remission.

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“…The two low-grade B-cell NHL arising in the conjunctiva, include extranodal marginal B-cell lymphoma (EMZL) and follicular lymphoma (FL), while the two high-grade types are diffuse large B-cell lymphoma (DLBCL) and mantle cell lymphoma (MCL). EMZL is the most frequent lymphoma subtype found in the conjunctival MALT system (>50%) and is considered to arise from neoplastically transformed marginal zone cells in reactive follicles [ 1 , 6 ].…”

Section: Definitionmentioning

confidence: 99%

“…RLH can occur as a result of antigen stimulation of the MALT tissue. It is more common in younger populations, and histological studies show equal population sizes of polyclonal B- and T- lymphocytes[ 6 ]. The neoplastic counterpart of the marginal zone cells in these reactive follicles is termed EMZL.…”

Section: Clinical Featuresmentioning

confidence: 99%

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Conjunctival Lymphoma

McGrath

Ryan

Warrier

et al. 2022

Eye

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Lymphoma of the conjunctiva is an ocular malignancy derived from clonal proliferation of lymphocytes. The majority of conjunctival lymphoma is extranodal marginal zone B-Cell lymphoma (EMZL), however diffuse large B-cell (DLBCL), follicular (FL), mantle cell (MCL) and T- cell subtypes are also seen. Clinical manifestations are non-specific, but include unilateral or bilateral painless salmon-pink conjunctival lesions. Approaches to treatment have centered around local immunomodulation, often with Interferon-α2b or Rituximab (anti-CD20 monoclonal antibody) with or without radiation. Although conjunctival lymphoma is generally considered an indolent disease, recent advances in next-generation sequencing have improved clinicians’ ability to predict future recurrence or systemic disease through assessment of cytogenic and molecular features. In this paper, we review the classification, clinical features, diagnostic techniques, and emerging strategies for management and prognostication of conjunctival lymphomas.

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Can conjunctival lymphoma be a clinical diagnosis?

Cited by 4 publications

References 15 publications

Conjunctival Follicular Lymphoma after Treatment for Invasive Squamous Cell Carcinoma

Conjunctival Follicular Lymphoma after Treatment for Invasive Squamous Cell Carcinoma

A case of palpebral conjunctival MALT lymphoma misdiagnosed as giant papillary conjunctivitis

Conjunctival Lymphoma

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