Can Carotid Bulb Plaque Assessment Rule Out Significant Coronary Artery Disease? A Comparison of Plaque Quantification by Two- and Three-Dimensional Ultrasound

Johri, Amer M.; Chitty, David W.; Matangi, M.; Malik, Paul; Mousavi, Parvin; Day, Andrew G.; Gravett, Matthew; Simpson, Chris

doi:10.1016/j.echo.2012.09.005

Cited by 65 publications

(34 citation statements)

References 29 publications

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“…It is possible that more advances imaging approaches might improve the value of plaque measurements for predicting coronary artery disease prevalence and progression 25 .…”

Section: Discussionmentioning

confidence: 99%

Carotid Artery Plaque and Progression of Coronary Artery Calcium: The Multi-Ethnic Study of Atherosclerosis

Polak

Tracy

Harrington

et al. 2013

Journal of the American Society of Echocardiography

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Background Carotid and coronary atherosclerosis are associated to each other in imaging and autopsy studies. We evaluated whether carotid artery plaque seen on carotid ultrasound can predict incident coronary artery calcification (CAC). Materials and Methods We repeated Agatston calcium score measurements in 5445 participants of the Multi-Ethnic Study of Atherosclerosis (MESA) (mean age 57.9 years; 62.9% female). Internal carotid artery lesions were graded as 0%, 1-24%, >25% diameter narrowing and intima-media thickness (IMT) was measured. Plaque was present for any stenosis > 0%. CAC progression was evaluated with multivariable relative risk regression in cases with CAC = 0 at baseline and with multivariable linear regression for CAC > 0 adjusting for cardiovascular risk factors, body mass index, ethnicity, and common carotid IMT. Results CAC was positive at baseline in 2708/5445 (49.7%) participants and became positive in 458/2837 (16.1%) at mean interval of 2.4 years between repeat examinations. Plaque and ICA IMT were both strongly associated with presence of CAC. After statistical adjustment, presence of carotid artery plaque significantly predicted incident CAC with a relative risk(RR) of 1.37 (95% Confidence Intervals: 1.12, 1.67). Incident CAC was associated with ICA IMT with an RR of 1.13 (95% Confidence Intervals: 1.03, 1.25) for each mm increase. Progression of CAC was also significantly associated (p < 0.001) with plaque and ICA IMT. Conclusions In individuals free of cardiovascular disease, subjective and quantitative measures of carotid artery plaques by ultrasound imaging are associated with CAC incidence and progression.

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“…It is possible that more advances imaging approaches might improve the value of plaque measurements for predicting coronary artery disease prevalence and progression 25 .…”

Section: Discussionmentioning

confidence: 99%

Carotid Artery Plaque and Progression of Coronary Artery Calcium: The Multi-Ethnic Study of Atherosclerosis

Polak

Tracy

Harrington

et al. 2013

Journal of the American Society of Echocardiography

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“…Carotid TPA has been used successfully to treat arteries instead of risk factors, 10 and this approach markedly reduced risk among high-risk patients with asymptomatic carotid stenosis. 30 Brook et al 31 found that TPA was more closely related to coronary stenosis than IMT, coronary calcium, or CRP, and Johri et al 32 found that plaque volume was more sensitive than plaque thickness for prediction of coronary stenosis. Our findings suggest that measurement of TPV will be a useful approach to treating high-risk patients; this hypothesis will need to be tested in a clinical trial.…”

Section: July 2013mentioning

confidence: 99%

Progression of Carotid Plaque Volume Predicts Cardiovascular Events

Wannarong

Párraga

Buchanan

et al. 2013

Stroke

150

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Participants in the study were patients being followed up in the Stroke Prevention Clinic or the Premature Atherosclerosis Clinic at University Hospital, London, Ontario, Canada. Participants were screened for this study by measurement of their carotid TPA. 15 WeBackground and Purpose-Carotid ultrasound evaluation of intima-media thickness (IMT) and plaque burden has been used for risk stratification and for evaluation of antiatherosclerotic therapies. Increasing evidence indicates that measuring plaque burden is superior to measuring IMT for both purposes. We compared progression/regression of IMT, total plaque area (TPA), and total plaque volume (TPV) as predictors of cardiovascular outcomes. Methods-IMT, TPA, and TPV were measured at baseline in 349 patients attending vascular prevention clinics; they had TPA of 40 to 600 mm 2 at baseline to qualify for enrollment. Participants were followed up for ≤5 years (median, 3.17 years) to ascertain vascular death, myocardial infarction, stroke, and transient ischemic attacks. Follow-up measurements 1 year later were available in 323 cases for IMT and TPA, and in 306 for TPV. Results-Progression

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“…CIMT is mainly a result of hypertensive thickening of smooth muscles in the media layer, but atherosclerosis is, in fact, a process involving the entity of the arterial wall. Thus plaque volume and area, which represent focal increases in arterial wall thickness, are more likely to represent regions of atherosclerosis rather than medial hypertrophy [60]. Analysis of plaque texture, use of contrast, assessment of plaque calcification and synergism with other imaging, plasma, or genetic biomarkers are all important areas requiring greater study.…”

Section: Evaluation Of Atherosclerosismentioning

confidence: 98%

Real-time three-dimensional echocardiography: never before clinical efficacy looked so picturesque

Aggeli

Felekos

Kastellanos

et al. 2015

International Journal of Cardiology

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Can Carotid Bulb Plaque Assessment Rule Out Significant Coronary Artery Disease? A Comparison of Plaque Quantification by Two- and Three-Dimensional Ultrasound

Cited by 65 publications

References 29 publications

Carotid Artery Plaque and Progression of Coronary Artery Calcium: The Multi-Ethnic Study of Atherosclerosis

Carotid Artery Plaque and Progression of Coronary Artery Calcium: The Multi-Ethnic Study of Atherosclerosis

Progression of Carotid Plaque Volume Predicts Cardiovascular Events

Real-time three-dimensional echocardiography: never before clinical efficacy looked so picturesque

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