Can biomarkers help us to better diagnose and manage sepsis?

Schuetz, Philipp; Plebani, Mario

doi:10.1515/dx-2014-0073

Cited by 8 publications

(5 citation statements)

References 47 publications

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“…Combining WBC count with MDW was an effective predictor of sepsis. This confirms the idea that there is no one parameter that combines the required sensitivity and specificity to precisely diagnose sepsis [ 27 , 28 ]. Furthermore, almost half of the confirmed sepsis cases had decreased WBC counts (leukopenia).…”

Section: Discussionsupporting

confidence: 78%

“…A total of 147 Saudi Arabian neonates admitted at the NICU at KSUMC were enrolled in this study. A total of 70 neonates were enrolled into the control group, while 77 neonates were included in the study group, which was later subdivided into the sepsis (28) and OHC (49) groups (Table 1). Among the samples, 72 (48.98%) were from males, and 75 (51.02%) were from females.…”

Section: Patient Characteristicsmentioning

confidence: 99%

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Blood Biomarkers of Neonatal Sepsis with Special Emphasis on the Monocyte Distribution Width Value as an Early Sepsis Index

Mubaraki,

Faqihi,

AlQhtani

et al. 2023

Medicina

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Background and Objectives: Early detection of neonatal sepsis is critical because it is potentially fatal. Therefore, sepsis biomarkers of sufficient sensitivity and specificity are needed. This study aimed to evaluate the utility of peripheral blood parameters as neonatal sepsis biomarkers and the diagnostic performance of the monocyte distribution width (MDW) in sepsis in a neonatal intensive care unit. Materials and Methods: A cross-sectional study was conducted from September 2019 to August 2020 at the King Saud University Medical City in Riyadh, Saudi Arabia. Samples were collected and organised as follows: 77 study cases were subdivided into two subgroups ((other health complication (49) and sepsis (28)), and there were 70 controls. The causative microorganisms of neonatal sepsis were isolated. Peripheral blood samples were collected from each neonate in an ethylenediaminetetraacetic acid tube for a complete blood count and a leukocyte differential count. Moreover, the receiver operating characteristic (ROC) curve analysis was used to measure the diagnostic performance of the MDW. Results: The haematological parameters and neonatal sepsis cases had a considerable correlation. The MDW was the most significant haematological parameter. The ROC analysis of the MDW demonstrated that the area under the curve was 0.89 (95% confidence interval: 0.867 to 0.998) with a sensitivity of 89.3%, a specificity of 88.2%, and a negative predictive value of 97.2% at the cut-off point of 23. Conclusions: The use of haematological parameters is feasible and can be performed rapidly. Neonatal sepsis showed a strong correlation with leukopenia, anaemia, thrombocytopenia, and an elevated MDW value. Moreover, the ROC curve analysis confirmed the high diagnostic ability of the MDW in neonatal sepsis prediction.

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Section: Discussionsupporting

confidence: 78%

Section: Patient Characteristicsmentioning

confidence: 99%

Blood Biomarkers of Neonatal Sepsis with Special Emphasis on the Monocyte Distribution Width Value as an Early Sepsis Index

Mubaraki,

Faqihi,

AlQhtani

et al. 2023

Medicina

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“…Therefore, the cornerstones of sepsis care remain its early recognition. Currently, no single laboratory test or specific standalone biomarker has sufficient sensitivity and specificity to timely and accurately diagnosis sepsis [15,16]. Among the most available, PCT has been FDA-approved for the assessment of risk for developing sepsis in critical patients admitted in ICU, but PCT presents more than one limitation and needs to be interpreted in the clinical context [17,18].…”

Section: Discussionmentioning

confidence: 99%

Monocyte distribution width (MDW) parameter as a sepsis indicator in intensive care units

Piva

Zuin

Pelloso

et al. 2021

Clinical Chemistry and Laboratory Medicine (CCLM)

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Objectives Patients in Intensive Care Units (ICU) are a high-risk population for sepsis, recognized as a major cause of admission and death. The aim of the current study was to evaluate the diagnostic accuracy and prognostication of monocyte distribution width (MDW) in sepsis for patients admitted to ICU. Methods Between January and June 2020, we conducted a prospective observational study during the hospitalization of 506 adult patients admitted to the ICU. MDW was evaluated in 2,367 consecutive samples received for routine complete blood counts (CBC) performed once a day and every day during the study. Sepsis was diagnosed according to Sepsis-3 criteria and patients enrolled were classified in the following groups: no sepsis, sepsis and septic shock. Results MDW values were significantly higher in patients with sepsis or septic shock in comparison to those within the no sepsis group [median 26.23 (IQR: 23.48–29.83); 28.97 (IQR: 21.27–37.21); 21.99 (IQR: 19.86–24.36) respectively]. ROC analysis demonstrated that AUC is 0.785 with a sensitivity of 66.88% and specificity of 77.79% at a cut-off point of 24.63. In patients that developed an ICU-acquired sepsis MDW showed an increase from 21.33 [median (IQR: 19.47–21.72)] to 29.19 [median (IQR: 27.46–31.47)]. MDW increase is not affected by the aetiology of sepsis, even in patients with COVID-19. In sepsis survivors a decrease of MDW values were found from the first time to the end of their stay [median from 29.14 (IQR: 26.22–32.52) to 25.67 (IQR: 22.93–30.28)]. Conclusions In ICU, MDW enhances the sepsis detection and is related to disease severity.

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“…In Supplemental Table 1, we overview the most studied ones. 20 –23 Among these, soluble fms-like tyrosine kinase-1 demonstrated to be the most promising and novel prognostic marker in sepsis. 21,24…”

Section: Classic Circulating Markers Of Edmentioning

confidence: 99%

Novel Biomarkers for Evaluation of Endothelial Dysfunction

et al. 2020

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Endothelial dysfunction is one of the earliest indicators of cardiovascular (CV) dysfunction, and its evaluation would be of considerable importance to stratify CV risk of many diseases and to assess the efficacy of atheroprotective treatments. Flow-mediated dilation is the most widely used method to study endothelial function. However, it is operator-dependent and can be influenced by physiological variations. Circulating biomarkers are a promising alternative. Due to the complexity of endothelial function, many of the biomarkers studied do not provide consistent information about the endothelium when measured alone. New circulating markers are being explored and some of them are thought to be suitable for the clinical setting. In this review, we focus on novel biomarkers of endothelial dysfunction, particularly endothelial microparticles, endocan, and endoglin, and discuss whether they fulfill the criteria to be applied in clinical practice.

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Can biomarkers help us to better diagnose and manage sepsis?

Cited by 8 publications

References 47 publications

Blood Biomarkers of Neonatal Sepsis with Special Emphasis on the Monocyte Distribution Width Value as an Early Sepsis Index

Blood Biomarkers of Neonatal Sepsis with Special Emphasis on the Monocyte Distribution Width Value as an Early Sepsis Index

Monocyte distribution width (MDW) parameter as a sepsis indicator in intensive care units

Novel Biomarkers for Evaluation of Endothelial Dysfunction

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