Can beta stiffness index be proposed as risk factor for dementia

Impaired Aβ clearance: a potential link between atherosclerosis and Alzheimer’s disease

“…Therefore, arterial stiffness is strongly associated with the progressive deposition of Aβ in the brain, a conclusion also supported by prior work showing associations between AD and peripheral vascular disease (Newman et al, 2005), and carotid artery intima-media thickness (Hofman et al, 1997; Gorgone et al, 2009). The interplay between CBF impairment, increased arterial rigidity, and AD has been confirmed by several similar investigations (Alsop et al, 2000; van Oijen et al, 2007; Dai et al, 2009; Jurasic et al, 2009; Silvestrini et al, 2009). These data, collectively, suggest that noninvasive assessments of macroangiopathic atherosclerosis with modern neuroimaging techniques might aid in identifying those patients potentially at greatest risk of developing dementia, including AD, and who could benefit most from strict vascular risk factor control and vasoprotective therapies.…”

Vascular Health Indices and Cognitive Domain Function: Singapore Longitudinal Ageing Studies

“…To our knowledge, only one published study has correlated a direct measure of CCA stiffness to cognitive performance. Using the same eTRACKING method, Jurasic et al [19]. found higher ␤ index in 38 patients with dementia compared to controls but there was considerable overlap, and confounders were not controlled for.…”

“…Several groups have reported associations with cognitive impairment and decline with increasing carotid IMT [10][11][12][13][14][15] and conduit arterial stiffness [8,[16][17][18]. The vast majority of studies on arterial stiffness have used PP, CFPWV, or brachialankle pulse wave velocity rather than direct measures of local arterial stiffness [19]. There are also no studies correlating cognition and peripheral vasodilator response as a measure of endothelial dysfunction using the novel fingertip pulse amplitude tonometry, a nonoperator dependent technology.…”

Linking atherosclerosis to Alzheimer s disease focus on biomarkers

“…The results showed a linear association between progression of carotid wall changes and of cognitive decline. Similarly, Jurasic et al (109) have also reported that the results of Mini Mental State Examination of AD patients relate to changes of arterial stiffness of the common carotid artery. It is noteworthy that de la Torre (110) has shown that regional cerebral hypoperfusion as assessed by single-photon emission CT (SPECT) or from uptake of injected fluorine-18-labelled fluorodeoxyglucose with PET (positron emission tomography) is one of the earliest, if not the earliest, marker of AD symptoms.…”