Can atrophic‐erosive oral lichen planus promote cardiovascular diseases? A population‐based study

Conrotto, Davide; Barattero, Roberta; Carbone, M; Gambino, Alessio; Sciannameo, Veronica; Ricceri, Fulvio; Conrotto, Federico; Broccoletti, Roberto; Arduino, Paolo Giacomo

doi:10.1111/odi.12700

Cited by 10 publications

(9 citation statements)

References 19 publications

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“…This also suggests that CKD prevention and interference could effectively reduce the incidence and/or severity of OLP. OLP is frequently linked to systemic comorbidities, including hypertension, diabetes, and CVD (8,9). In our study, 11.7% of patients had hypertension and 4.7% had diabetes; these rates were within the range of those reported for hypertension (11-27%) (28-30) and diabetes (1.6-37.7%) previously (8).…”

Section: Discussionsupporting

confidence: 73%

“…OLP is a chronic, relapsing disease often associated with systemic comorbidities. Comorbidities of OLP have been preliminarily elucidated and described, mainly in the fields of diabetes and CVD (8,9). Recently, psoriasis has also been robustly demonstrated to be associated with CKD by some well-designed studies (15).…”

Section: Discussionmentioning

confidence: 99%

“…Despite a variety of treatments being available, this disease often severely affects patients' quality of life due to its protracted clinical course (4,5) and, in particular, its potential for malignant transformation (6,7). Although the etiology and pathogenesis of OLP remain unclear, it has been reported to be associated with several systemic comorbidities including diabetes mellitus (8) and cardiovascular disease (CVD) (9). Furthermore, it is noteworthy that in clinical practice, a proportion of patients with OLP suffer from renal dysfunction, such as abnormal serum creatinine and urine albumin levels (Figures S1,S2).…”

Section: Introductionmentioning

confidence: 99%

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Prevalence and risk of chronic kidney disease in oral lichen planus: a large cross-sectional study from eastern China

Deng¹,

Wang²,

Shen³

et al. 2021

Ann Transl Med

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Background: Oral lichen planus (OLP) is a chronic inflammatory mucocutaneous disease which is frequently associated with comorbidities such as diabetes and cardiovascular diseases. However, little is known about the association of OLP with impaired kidney function. To elucidate the possible association of chronic kidney disease (CKD) with OLP and its severity, this study investigated the prevalence of CKD as well as its risk factors in patients with OLP.Methods: A large prospective cross-sectional study of 1,021 patients with OLP was carried out using questionnaires and laboratory tests available from an oral medicine clinic at a university in eastern China.According to the Kidney Disease: Improving Global Outcomes (KDIGO) diagnostic guideline, CKD was classified based on the estimated glomerular filtration rate (eGFR, <60 mL/min/1.73 m 2 ) or urinary albumin to creatinine ratio (UACR, >30 mg/g). Results:The prevalence of CKD in the patients with OLP in this study was 14.3% (95% CI, 12.3-16.6%), which was higher than that in the general Chinese population (10.8%; 95% CI, 10.2-11.3%). The mean values of serum creatinine, eGFR, UACR, and urine N-acetyl-β-D-glucosidase in patients with CKD were significantly higher than those in patients without CKD (all P<0.01). Pearson's correlation analysis revealed that CKD stage and UACR were positively correlated with the severity of OLP (both P<0.001).Importantly, multivariate regression analysis revealed that age ≥58 years old, female sex, and hypertension were independent risk factors for incident CKD and abnormal UACR (>30 mg/g) in patients with OLP (all P<0.01).Conclusions: This study has reported for the first time that CKD is a comorbidity in patients with OLP.The occurrence and staging of incident CKD are associated with OLP and its severity.

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Section: Discussionsupporting

confidence: 73%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Prevalence and risk of chronic kidney disease in oral lichen planus: a large cross-sectional study from eastern China

Deng¹,

Wang²,

Shen³

et al. 2021

Ann Transl Med

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“…460,461 A few of the RTKs are involved in Wnt signaling, for instance RYK interacts with Frizzled proteins, 334 ROR2 interacts with Vangl2 462 and Frizzled proteins, 463 PTK7 interacts with LRP6 464 and Frizzled proteins, 465 and MuSK interacts with LRP4. 466,467 Several RTKs interact with semaphoring receptors, including some which interact with plexins, such as MET, 468,469 ErbB2, 470,471 VEGFR2, 472 and FGFR1; 472 VEGFR2 interacts with nuerophilin-1 473,474 and nuerophilin-2. 475 These interactions have a wide range of important biological consequences.…”

Section: Beyond the Rtk Interactomementioning

confidence: 99%

The RTK Interactome: Overview and Perspective on RTK Heterointeractions

Paul

Hristova

2018

Chem. Rev.

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Receptor tyrosine kinases (RTKs) play important roles in cell growth, motility, differentiation, and survival. These single-pass membrane proteins are grouped into subfamilies based on the similarity of their extracellular domains. They are generally thought to be activated by ligand binding, which promotes homodimerization and then autophosphorylation in trans. However, RTK interactions are more complicated, as RTKs can interact in the absence of ligand and heterodimerize within and across subfamilies. Here, we review the known cross-subfamily RTK hetero-interactions and their possible biological implications, as well as the methodologies which have been used to study them. Moreover, we demonstrate how thermodynamic models can be used to study RTKs and to explain many of the complicated biological effects which have been described in the literature. Finally, we discuss the concept of the RTK interactome: a putative, extensive network of interactions between the RTKs. This RTK interactome can produce unique signaling outputs; can amplify, inhibit, and modify signaling; and can allow for signaling backups. The existence of the RTK interactome could provide an explanation for the irreproducibility of experimental data from different studies and for the failure of some RTK inhibitors to produce the desired therapeutic effects. We argue that a deeper knowledge of RTK interactome thermodynamics can lead to a better understanding of fundamental RTK signaling processes in health and disease. We further argue that there is a need for quantitative, thermodynamic studies that probe the strengths of the interactions between RTKs and their ligands and between different RTKs.

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“…The OLP clinical forms are usually classified as follows: (a) white lichen (WL), which included the papular, reticular and plaque forms; (b) red lichen (RL), which included all the atrophic or erosive forms, irrespective of a contemporaneous presence of a white form ( 1 ). It has been supposed that these different clinical manifestations may be related to dissimilar biological events; furthermore, a significant involvement of specific classes of T-lymphocytes, responsible of marked tissue damage, could determine the development of erosive lesions ( 3 ).…”

Section: Introductionmentioning

confidence: 99%

Evidence of earlier thyroid dysfunction in newly diagnosed oral lichen planus patients: a hint for endocrinologists

Arduino

Karimi

Tirone³

et al. 2017

Endocrine Connections

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The association between oral lichen planus (OLP) and hypothyroidism has been debated with conflicting results: some authors detected a statistically significant association between these two, while others did not confirm it. The aim of this study was to evaluate the thyroid status in patients with newly diagnosed OLP to test the null hypothesis that thyroid disease is not associated with an increased incidence of oral lesions, with a prospective case-control approach. A total of 549 patients have been evaluated, of whom 355 were female. Odds ratio (OR) and 95% confidence intervals (CIs) were obtained. Patients suffering from thyroid diseases were associated with an almost 3-fold increased odds of having OLP (OR 2.85, 95% CI: 1.65–4.94), after adjusting this analysis for age, gender, body mass index, smoking status, diabetes, hypertension and hepatitis C infection. It would be appropriate to further investigate the possible concomitance of OLP among patients with thyroid disorder; endocrinologists should be aware of this association, especially because OLP is considered a potentially malignant oral disorder.

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Can atrophic‐erosive oral lichen planus promote cardiovascular diseases? A population‐based study

Abstract: Patients with RL could possibly have a higher risk of developing ACS. Further analysis on larger cohort is however warranted.

Cited by 10 publications

References 19 publications

Prevalence and risk of chronic kidney disease in oral lichen planus: a large cross-sectional study from eastern China

Prevalence and risk of chronic kidney disease in oral lichen planus: a large cross-sectional study from eastern China

The RTK Interactome: Overview and Perspective on RTK Heterointeractions

Evidence of earlier thyroid dysfunction in newly diagnosed oral lichen planus patients: a hint for endocrinologists

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