Can apical periodontitis affect serum levels of CRP, IL-2, and IL-6 as well as induce pathological changes in remote organs?

Zhang, Jinxiu; Huang, Xiaojing; Lu, Bingling; Chengfei, Zhang; Cai, Zhiyu

doi:10.1007/s00784-015-1646-6

Cited by 38 publications

(58 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…A link between periodontitis and liver disease is best described in animal models, but clinical evidence is now also emerging . Akinkugbe et al recently reported that periodontitis was an independent risk factor for incident NAFLD, and Yoneda et al found that treatment of periodontitis led to reduction in serum transaminase levels.…”

Section: Discussionmentioning

confidence: 99%

“…Periodontitis could affect the liver by several potential mechanisms. First, in periodontitis, oral bacteria and locally produced proinflammatory cytokines can enter the bloodstream and potentially induce liver damage . Secondly, oral bacteria such as Porphyromonas gingivalis can cause alterations in the gut microbiota, with subsequent decreased expression of tight‐junction proteins in the ileum and increased gut translocation and systemic inflammation .…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Periodontitis is associated with incident chronic liver disease—A population‐based cohort study

Helenius‐Hietala

Suominen

Ruokonen

et al. 2018

Liver International

View full text Add to dashboard Cite

Background & Aims Chronic liver disease is a major health concern worldwide and the identification of novel modifiable risk factors may benefit subjects at risk. Few studies have analyzed periodontitis as a risk factor for liver complications. We studied whether periodontitis is associated with incident severe liver disease. Methods The study comprised 6165 individuals without baseline liver disease who participated in the Finnish population‐based Health 2000 Survey (BRIF8901) during 2000‐2001, a nationally representative cohort. Follow‐up was until 2013 for liver‐related admissions, liver cancer and mortality from National Hospital Discharge, Finnish Cancer Registry and Causes of Death Register, Statistics Finland. Mild to moderate periodontitis was defined as ≥1 tooth with periodontal pocket ≥4 mm deep, and advanced periodontitis as ≥5 teeth with such pockets. Multiple confounders were considered. Results A total of 79 subjects experienced a severe liver event during follow‐up. When adjusted for age, sex and number of teeth, hazards ratios by Cox regression regarding incident severe liver disease were, for mild to moderate periodontitis, 2.12 (95% CI 0.98‐4.58), and, for advanced periodontitis, 3.69 (95% CI 1.79‐7.60). These risk estimates remained stable after additionally adjusting for alcohol use, smoking, metabolic risk, serum gamma‐glutamyltransferase, dental‐care habits, lifestyle and socioeconomic status. Periodontal disease‐associated liver risk was accentuated among subjects with non‐alcoholic fatty liver disease or heavy alcohol use at baseline. Conclusions Periodontitis was associated with incident liver disease in the general population independently of various confounders. As a preventable disease, periodontal disease might present a modifiable risk factor for chronic liver disease.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Periodontitis is associated with incident chronic liver disease—A population‐based cohort study

Helenius‐Hietala

Suominen

Ruokonen

et al. 2018

Liver International

View full text Add to dashboard Cite

show abstract

“…There is growing evidence that inflammatory diseases and infections may be the cause of and related to the emergence of cardiovascular problems . As an oral disease, AP is known to be a potential risk factor for cardiovascular diseases . Apical periodontitis and cardiovascular damage have complex etiologies and may have common general risk factors as well as pathogenic mechanisms.…”

mentioning

confidence: 99%

“…Previous animal studies on rats have demonstrated that AP affects blood homeostasis; it increases the serum levels of inflammatory mediators and thus can affect systemic health . Alterations in expression of inflammatory markers, such as creatine kinase (CK), alkaline phosphatase (ALP), and lactate dehydrogenase (LDH), and in the activities of antioxidant enzymes, such as superoxide dismutase (SOD), have previously been studied in cardiovascular diseases and marginal periodontitis .…”

mentioning

confidence: 99%

See 1 more Smart Citation

Protective effect of alpha‐lipoic acid against apical periodontitis‐induced cardiac injury in rats

Şehirli¹,

Aksoy²,

Basmacı³

et al. 2019

European J Oral Sciences

View full text Add to dashboard Cite

This study was designed to assess the possible protective effect of alpha‐lipoic acid (ALA) on apical periodontitis (AP)‐induced cardiac injury. Wistar albino rats were randomized into four groups: control; ALA; AP; and ALA + AP. Rats of the control and ALA groups were not endodontically treated, but saline and ALA (100 mg kg−1) were administered. In rats of the AP and ALA + AP groups, the pulp chambers of mandibular first molar teeth were exposed and left open for 30 d to induce AP. Saline and ALA (100 mg kg−1) were administered intraperitoneally every 24 h during the experiment. At the end of the experiment, the rats were killed. Establishment of AP was verified by radiographic and histopathological evaluation. Serum alkaline phosphatase (ALP), lactate dehydrogenase (LDH), creatine kinase (CK), and superoxide dismutase (SOD) activities were determined using an automated biochemical analyzer, and the structural cardiac injury was assessed pathologically. Serum ALP, LDH, and CK activities were elevated, and SOD activities were decreased, in the AP group. The changed enzyme activities were significantly normalized by treatment with ALA. We conclude that ALA administration alleviated the AP‐induced heart injury and improved cardiac structure and function, and therefore this agent may be of potential therapeutic value in protecting cardiac tissue from systemic injury caused by AP.

show abstract

Effects of periodontitis and periodontal treatment on systemic inflammatory markers and metabolic profile in obese and non‐obese rats

Pereira

Jara

Antunes

et al. 2022

Journal of Periodontology

View full text Add to dashboard Cite

Background Little is known about a synergistic effect of periodontitis and obesity on systemic biomarkers and a possible effect periodontal treatment may exert. This study aimed to evaluate the impact of periodontitis and periodontal treatment on systemic inflammation and metabolic profile in obese and non‐obese rats. Methods Sixty male Wistar rats were randomly divided in six groups differentiated by diet and periodontal status: no periodontitis (G1 and G4), untreated ligature‐induced periodontitis (G2 and G5), and treated ligature‐induced periodontitis (G3 and G6). Groups G4, G5, and G6 were exposed to cafeteria diet to induce obesity. Periodontitis was induced by silk ligatures over 4 weeks (G2, G3, G5, and G6). Rats in G3 and G6 received scaling and root planing and were followed for additional 4 weeks. After sacrifice, serum levels of C‐reactive protein (CRP), interleukin (IL)‐1β, IL‐6, IL‐10, IL‐17a, tumor necrosis factor alfa (TNF‐α), glucose, triglycerides, and total cholesterol (TC) were compared between groups. Results CRP was significantly higher in obese rats with than without periodontitis (G5 = 10.15 versus G4 = 4.47 μg/L, P = 0.01). No beneficial effects of periodontal treatment were observed for CRP levels, IL‐6, IL‐1β, IL‐17a, and TNF‐α, glucose and triglycerides. Treated periodontitis (G6) exhibited significantly lower TC than the periodontitis group (G5) in obese rats. Conclusion Periodontitis increased serum CRP in obese rats, indicating a synergistic role of periodontitis in the systemic inflammatory burden triggered by obesity. The treatment of induced periodontitis reduced TC levels in obese rats.

show abstract

Can apical periodontitis affect serum levels of CRP, IL-2, and IL-6 as well as induce pathological changes in remote organs?

Abstract: AP may trigger a systemic immune response, impair remote organs, and affect the general health of patients.

Cited by 38 publications

References 38 publications

Periodontitis is associated with incident chronic liver disease—A population‐based cohort study

Periodontitis is associated with incident chronic liver disease—A population‐based cohort study

Protective effect of alpha‐lipoic acid against apical periodontitis‐induced cardiac injury in rats

Effects of periodontitis and periodontal treatment on systemic inflammatory markers and metabolic profile in obese and non‐obese rats

Contact Info

Product

Resources

About