Can antibiotic prescribing recover its downward trajectory during 2021?

Sanderson, Susie; Thompson, Wendy

doi:10.1038/s41404-021-0710-y

Cited by 2 publications

(1 citation statement)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A recent article found that AMR contributes to nearly 5-million deaths worldwide and is the direct cause of >1-million deaths/year (Murray et al, 2022). Some have termed the AMR crisis "the slow-motion pandemic" (Sanderson and Thompson, 2021) with estimates of 10 million deaths/year by 2050 (O'Neill, 2016), a number likely exacerbated by the widespread use of antibiotics during the COVID-19 global pandemic (Subramanya et al, 2021). Of great concern is that our arsenal of effective antibiotics is dwindling at an alarming rate, as extensively discussed elsewhere (Howard et al, 2013;Årdal et al, 2020;Bhavnani et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

Addressing Antibiotic Failure—Beyond Genetically Encoded Antimicrobial Resistance

Haney

Hancock

2022

Front. Drug. Discov.

View full text Add to dashboard Cite

Antibiotic failure can be defined as any clinical situation where treatment with antibiotics fails to cure the patient and remove the infection. Genetically-determined antibiotic resistance certainly contributes to antibiotic failure in the clinic, but this is not the only reason why antibiotics fail and it is likely not the most common cause of antibiotic failure. In this perspective article, we outline several widespread examples of situations where antibiotic treatment fails, even in the absence of formal resistance, including biofilm associated-infections (65% of all infections) as well as infections in sepsis (19.7% of all deaths) and immune compromised individuals. We then discuss various strategies that are being employed to address the issue of antibiotic failure and emphasize that antibiotic failure should be given increased awareness and resources to address this underappreciated but critical issue.

show abstract