Can aging be slowed down?

Malik, Aila; Hoenig, Leonard J.

doi:10.1016/j.clindermatol.2019.04.003

Cited by 12 publications

(9 citation statements)

References 21 publications

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“…[ 1 ] With the aggravation of the current aging society, the incidence of osteoporosis in the elderly is also increasing year by year. [ 2 ] Due to the deterioration of physical movement of the elderly, walking is unstable, and patients are prone to falls or collisions, and often accompanied by fractured ankle. In recent years, despite advances in surgical techniques and molecular targeted therapy and immunotherapy, the prognosis of osteoporosis is still unsatisfactory.…”

Section: Introductionmentioning

confidence: 99%

Vitamin B6 as a novel risk biomarker of fractured ankles

Zhang

Wan

et al. 2021

Medicine

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Ankle fractures are the most common intra-articular fractures. Osteoporosis is a common and frequent disease among the elderly with a poor prognosis and high risk of fractured ankles. However, the relationship between vitamin B6 and the incidence of fractured ankles in patients with osteoporosis is unclear. A total of 101 patients with osteoporosis were recruited. Clinical and followed-up information was recorded. And the vitamin B6, albumin, globulin, and hemoglobin in the blood were tested. Pearson's chi-squared and spearman test were performed to analyze the correlation between fractured ankles and relative parameters. Univariate and multivariate logistic regression, receiver operating characteristic curve analysis, univariate and multivariate Cox proportional hazards regression analysis, and Kaplan–Meier method were also performed. There exist strong relation between the expression level of vitamin B6 and fractured ankle ( P < .001). The expression of vitamin B6 [Odd ratio (OR) = 12.071, 95% confidence interval (CI): 4.69–31.143, P < .001] has a clear correlation with whether the patients have fractured ankles via the univariate logistic regression analysis. In terms of multivariate logistic regression level, vitamin B6 (OR = 15.384, 95% CI:5.195–45.556, P < .001) was significantly associated with fractured ankle. In addition, expression level of vitamin B6 [hazard ratio (HR) = 11.684, 95% CI: 6.419–21.267, P < .001] was significantly associated with Maintenance time from recovery to recurrence (MRTT) of patients with osteoporosis. Enhanced vitamin B6 is significantly correlated with the poor prognosis of patients with osteoporosis and the increasing incidence of fractured ankles.

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Section: Introductionmentioning

confidence: 99%

Vitamin B6 as a novel risk biomarker of fractured ankles

Zhang

Wan

et al. 2021

Medicine

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“…Nano forms that are in the transparent form are better tolerated by users. [38][39][40] Chemical sunscreens that consist of organic chemicals, such as para-aminobenzoic acid and benzophenones, act by absorbing UV rays. Visible and blue light promotes photoaging through the production of ROS, and can cause pigment darkening, melasma and post-inflammatory hyperpigmentation in Fitzpatrick IV-VI skin types.…”

Section: Protection From Ultraviolet-infrared Rays Visible and Blue L...mentioning

confidence: 99%

“…Consuming foods with a low glycemic index, adopting the a Mediterranean diet, and using metformin with the recommendation of a doctor (when necessary) are recommended to reduce glycation. 39,42 Exercise can improve circulation and mitochondrial functionality, and regular sleep can help the body regenerate. 39…”

Section: Lifestyle Changesmentioning

confidence: 99%

Aging Skin and Anti-aging Strategies

Bay¹,

Topal²

2022

Explor Res Hypothesis Med

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The skin is a physical barrier that protects our body against various environmental, chemical and physical agents, and is the main organ that is easily visible as time progresses. Aging is a dynamic, progressive and undesirable biological process that unfortunately cannot be stopped, according to present knowledge. Intrinsic aging (chronological, spontaneous and biological aging) is a programmed natural process, while extrinsic aging (environmental aging and photoaging) is associated with sun exposure, smoking and malnutrition, which weakens the skin structure and functions. Over time, aging skin starts to lose elastin fibers, collagen and other proteins, which are the basic constituents that make skin healthy, bright, fit and elastic. There has been increasing interest in studies on various molecular and hormonal mechanisms, such as hormone dysfunction, changes in signaling pathways, the downregulation of mitochondrial function with cytokine increase, and mitochondrial DNA mutation. Antiaging treatment strategies can be divided into two parts: primary (basic) preventive antiaging approaches and secondary antiaging approaches after the phenotypic features of aging are revealed. The present study aims to review the literature information on the underlying causes of skin aging, healthy skin aging, and basic protective antiaging approaches. Understanding the extrinsic and intrinsic pathophysiological processes of aging would increase the effectiveness of future treatment-finding efforts.

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“…[ 3 ] The prevalence of osteoporosis in the elderly is rising year over year due to the contemporary aging society. [ 4 ] Due to the deterioration of physical movement of the elderly, walking is unstable, and patients are prone to falls or collisions, and often accompanied by spinal fractures. In recent years, despite advances in surgical techniques and molecular targeted therapy and immunotherapy, the prognosis of osteoporosis is still unsatisfactory.…”

Section: Introductionmentioning

confidence: 99%

Vitamin B12 as a novel risk biomarker of spinal fractures

Zheng

Xue

et al. 2022

Medicine

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Spinal fractures are common intra-articular fractures. Osteoporosis is a common and frequent disease among the elderly with a poor prognosis and a high risk of spinal fractures. However, the underlying factors for spinal fractures in patients with osteoporosis are unclear. A total of 105 patients with osteoporosis were recruited. Clinical and followed-up information was recorded. And vitamin B12, vitamin B2, vitamin A, and vitamin B9 in the blood were tested. Pearson's chi-squared and spearman tests were performed to analyze the correlation between spinal fractures and relative parameters. Univariate and multivariate logistic regression, univariate and multivariate Cox proportional hazards regression analysis. There exists strong relation between the expression level of vitamin B12 and spinal fractures. Pearson's chi-square and Spearman correlation test showed a strong association between vitamin B12 and vitamin B9 and a spinal fracture. Univariate logistic regression analysis showed that vitamin B12 and vitamin B9 were significantly associated with a spinal fracture. Multivariate logistic regression analysis showed that vitamin B12 was associated considerably with a spinal fracture. In addition, Cox regression analysis showed that vitamin B12 expression was significantly associated with maintenance time from recovery to recurrence (MTRR) of spinal fractures in patients with osteoporosis. Enhanced vitamin B12 is significantly correlated with the poor prognosis of patients with osteoporosis and the increasing incidence of a spinal fracture. The higher the vitamin B12, the higher the risk of spinal fracture and the shorter the time to spinal fracture recurrence.

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Can aging be slowed down?

Cited by 12 publications

References 21 publications

Vitamin B6 as a novel risk biomarker of fractured ankles

Vitamin B6 as a novel risk biomarker of fractured ankles

Aging Skin and Anti-aging Strategies

Vitamin B12 as a novel risk biomarker of spinal fractures

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