Can acupuncture enhance therapeutic effectiveness of antidepressants and reduce adverse drug reactions in patients with depression? A systematic review and meta-analysis

Xu, Mingmin; Pei, Guo; Guo, Yu; Wei, Yulong; Ma, Qingyu; Wang, Lu; Chen, Yue

doi:10.1016/j.joim.2022.05.002

Cited by 13 publications

(10 citation statements)

References 58 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Accumulating evidence have demonstrated that acupuncture could improve symptoms and quality of life for patients with depression, or alleviate the depression-like behaviors in animal model subjected to depression [ 32 , 33 , 30 , 42 ]. Acupuncture has also been suggested to be an adjunct to antidepressants, which may enhance the antidepressant effect and reduce the adverse drug reactions in patients receiving antidepressants [ 43 ]. Baihui (GV20) and Yintang (GV29) have been identified to be the main acupoint prescription unit for the relief of nervous system disorders, including depression [ 43 ].…”

Section: Discussionmentioning

confidence: 99%

“…Acupuncture has also been suggested to be an adjunct to antidepressants, which may enhance the antidepressant effect and reduce the adverse drug reactions in patients receiving antidepressants [ 43 ]. Baihui (GV20) and Yintang (GV29) have been identified to be the main acupoint prescription unit for the relief of nervous system disorders, including depression [ 43 ]. In the present study, acupuncture at Baihui (GV20) and Yintang (GV29) was applied to be the acupuncture modulation for the treatment of depression in rats exposed to CRS.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Acupuncture Ameliorates Depression-Like Behaviors Through Modulating the Neuroinflammation Mediated by TLR4 Signaling Pathway in Rats Exposed to Chronic Restraint Stress

Jiang,

Long,

Wang

et al. 2023

Mol Neurobiol

View full text Add to dashboard Cite

Recently, emerging evidence has identified that stress-induced activation of neuroinflammation is considered to be one of the most prevalently precipitating factors in the pathogenesis of depression. Data from clinical trials and experimental findings has verified the efficacy and safety of acupuncture in the prevention and treatment of depression. However, the mechanism of the preventive effect of acupuncture for depression has not been fully elucidated. The current study aimed to investigate the preventive effect and mechanism of acupuncture through modulating the neuroinflammation mediated by toll-like receptor 4 (TLR4) signaling pathway in rats exposed to chronic restraint stress (CRS). All rats were subjected to CRS for 21 days, with the exception of rats in control group. One hour before CRS, rats in acupuncture group were exposed to acupuncture at Baihui (GV20) and Yintang (GV29). The depression-like behaviors were evaluated by body weight assessment and sucrose preference test at 0, 7, 14, and 21 days. The expression of activated microglia in hippocampus was detected by immunofluorescence. The expression of key proteins on TLR4 signaling pathway of TLR4, MyD88, TRAF6, NF-κB p65, TNF-α, and mRNA of TLR4 in the hippocampus was detected by western blot and real-time quantitative polymerase chain reaction to investigate the effect of acupuncture on stress-induced activation of neuroinflammation. The present study provided evidence that acupuncture exerted potential preventive effect that might be mediated in part by suppressing the neuroinflammation induced by TLR4 signaling pathway, which may be a promising treatment target to improve current treatments for depression.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Acupuncture Ameliorates Depression-Like Behaviors Through Modulating the Neuroinflammation Mediated by TLR4 Signaling Pathway in Rats Exposed to Chronic Restraint Stress

Jiang,

Long,

Wang

et al. 2023

Mol Neurobiol

View full text Add to dashboard Cite

show abstract

“…A significant number of clinical and basic research data have verified the safety and efficacy of acupuncture in the treatment of MDD and acupuncture has been recognized and widely applied in many countries. It can be used alone or in combination with drugs, especially when combined with antidepressants, not only to improve primary and secondary depressive symptoms but also to reduce the side effects of drug treatment ( Xu M. M. et al, 2022 ). We have summarized the past decade of research on the possible mechanisms of acupuncture therapy (reference Table 2 ).…”

Section: Background Role Of Acupuncture In Mddmentioning

confidence: 99%

Exosomes may be the carrier of acupuncture treatment for major depressive disorder

Lyu

Zhou²,

Shi³

et al. 2023

Front. Behav. Neurosci.

View full text Add to dashboard Cite

The incidence of major depressive disorder (MDD) is increasing all over the world. There is a great need for complementary or alternative therapies with high safety, few side effects, and precise efficacy to care for MDD. In China, acupuncture has significant laboratory data and clinical trials to demonstrate its antidepressant efficacy. However, there is no clear answer as to how it works. Exosomes are membranous vesicles that rely on cellular multivesicular bodies (MVBs) fused to the cell membrane for release into the extracellular matrix. Almost all cell types are capable of producing and releasing exosomes. As a result, exosomes contain complex RNAs and proteins from their relatives (Cells that secretes exosomes). They can cross biological barriers and participate in biological activities, such as cell migration, angiogenesis, and immune regulation. These properties have made them a popular research topic. Some experts have suggested that exosomes may serve as delivery vehicles for acupuncture to work. This presents both an opportunity and a new challenge for improving the protocols of acupuncture as a treatment for MDD. To better define the relationship between MDD, exosomes, and acupuncture, we reviewed the literature from the last few years. Inclusion criteria included randomized controlled trials and basic trials evaluating acupuncture in the treatment or prevention of MDD, the role of exosomes in the development and progression of MDD, and the role of exosomes in acupuncture. We believe that acupuncture may affect the distribution of exosomes in vivo, and exosomes may be a new carrier for acupuncture treatment of MDD in the future.

show abstract

“…Multiple factors, including psychological, genetic, biochemical, and social-environmental factors, contribute to the development of depression [9][10][11]. When depression becomes recurrent and reaches a moderate or severe level, it can cause signi cant distress and interfere with daily functioning, and in severe cases, it can even lead to suicide [12].…”

Section: Introductionmentioning

confidence: 99%

The causal relationship between depression and low back pain: a two-sample Mendelian randomized study

Liu,

Peng

et al. 2023

Preprint

View full text Add to dashboard Cite

Background Mendelian randomization analysis was employed to examine the potential causal link between depression and low back pain. This analysis utilizes genetic variants as instrumental variables to help establish a causal relationship. By leveraging the genetic variants associated with depression as the exposure factor, the study aimed to investigate whether there is a causal effect on the development or severity of low back pain. This approach provides valuable insights into the potential causal association between these two conditions. Methods The entire Gene Association Study database (GWAS) was utilized for data mining in a study aiming to investigate the relationship between depression as the exposure factor and low back pain as the outcome factor. Mendelian randomization analysis was performed using regression models such as inverse variance weighting (IVW), the MR‒Egger method, the simple mode method, the weighted median method, and the weighted mode method. The objective was to uncover any potential causal relationship between the exposure factors and the outcome. Results In this study, a total of 25 single nucleotide polymorphism (SNP) loci were utilized as instrumental variables to assess the causal association between depression and low back pain. The inverse variance weighting method estimated that individuals with depression had a 1.71 times higher risk (OR) of experiencing low back pain than the healthy population (95% CI: 1.258 to 2.332, p=0.0006). Similarly, the weighted median method also supported a causal effect between depression and low back pain (95% CI: 1.180 to 2.789, p = 0.0007). Tests for heterogeneity using the inverse variance weighting and MR‒Egger regression methods indicated no significant heterogeneity. Furthermore, the MR‒Egger regression intercept terms and MRPRESSO method tests suggested that the results were less likely to be influenced by genetic pleiotropy. Leave-one-out analyses did not identify any nonspecific SNPs that unduly influenced the results. Overall, these findings provide stronger evidence for a causal relationship between depression and low back pain. Conclusions There may be a positive causal association between depression and low back pain.

show abstract

Can acupuncture enhance therapeutic effectiveness of antidepressants and reduce adverse drug reactions in patients with depression? A systematic review and meta-analysis

Cited by 13 publications

References 58 publications

Acupuncture Ameliorates Depression-Like Behaviors Through Modulating the Neuroinflammation Mediated by TLR4 Signaling Pathway in Rats Exposed to Chronic Restraint Stress

Acupuncture Ameliorates Depression-Like Behaviors Through Modulating the Neuroinflammation Mediated by TLR4 Signaling Pathway in Rats Exposed to Chronic Restraint Stress

Exosomes may be the carrier of acupuncture treatment for major depressive disorder

The causal relationship between depression and low back pain: a two-sample Mendelian randomized study

Contact Info

Product

Resources

About