Can a phenotype for recessive inheritance in breast cancer be defined?

Ellberg, Carolina; Jönsson, Göran; Olsson, Håkan

doi:10.1007/s10689-010-9355-4

Cited by 4 publications

(2 citation statements)

References 16 publications

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“…Part of the patient material has been used in previous studies (Ellberg et al 2012; Ellberg et al 2010; Ellberg & Olsson 2011; Jernstrom et al 1999). All patients were seen by the same physician at the Department of Oncology, Skåne University Hospital, Lund.…”

Section: Methodsmentioning

confidence: 99%

Autoimmune diseases and hypersensitivities improve the prognosis in ER-negative breast cancer

et al. 2013

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IntroductionBreast cancer (BC) is one of the leading causes of death among women worldwide. Immunostimulatory treatment has increasingly been used as adjuvant therapy in the last few years, in patients with melanoma and other cancer forms, often with an induction of autoimmunity as a consequence of a successful treatment. We aimed at investigating if coexisting autoimmune diseases (AD) or hypersensitivities (HS) similarly to the side effects of immunostimulatory treatment resulted in a better overall survival, compared to patients without these disorders.Material and methodsThe patient material used was a consecutive clinical material consisting of 1705 patients diagnosed with BC between 1980 and 2010 in Sweden. The patients were stratified according to coexisting AD, HS or lack of both. Overall survival was calculated using Kaplan-Meier and the Cox proportional hazard model.ResultsOur main finding was that BC patients with estrogen receptor (ER) negative tumors together with preexisting AD or HS had a statistically significant better overall survival (HR=0.53; 95% CI= 0.30-0.96) compared to patients without. Premenopausal BC patients with a coexistence of AD or HS had a better overall survival, but this was not statistically significant.DiscussionFor patients with premenopausal or ER-negative BC, coexistence with AD or HS was associated with a better overall survival. Although these findings require validation, and the mechanisms responsible need to be found, they hint to possible new treatment strategies for BC, especially for those with ER-negative tumors and potentially for premenopausal patients.Electronic supplementary materialThe online version of this article (doi:10.1186/2193-1801-2-357) contains supplementary material, which is available to authorized users.

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Section: Methodsmentioning

confidence: 99%

Autoimmune diseases and hypersensitivities improve the prognosis in ER-negative breast cancer

et al. 2013

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“…When removing breast cancer in mothers, 219 (13%) patients had mothers diagnosed with other cancers. Patients with tubular breast cancer had an increased number of sisters with cancer (21%) [14], whereas lobular breast cancer patients had an increased number of fathers diagnosed with cancer. Ever-use of HRT was most common among patients with tubular and lobular breast cancer, and least common among patients with mucinous breast cancer (Table 1).…”

Section: Resultsmentioning

confidence: 99%

Breast cancer patients with lobular cancer more commonly have a father than a mother diagnosed with cancer

Ellberg

Olsson

2011

BMC Cancer

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BackgroundThe association between lobular breast cancer and family history is not clear. The aim of the study was to possibly identifying new hereditary patterns predisposing for cancer in the different histopathologic subtypes of breast cancer, with focus on patients with lobular breast cancer and cancer in their first degree relatives.MethodsIn 1676 consecutive breast cancer patients detailed family history of cancer was related to histopathologic subtype of breast cancer.ResultsPatients with lobular breast cancer were found to be significantly positively associated with having a father diagnosed with cancer, OR 2.17 (95% confidence interval (CI) 1.37-3.46). The finding persisted after excluding breast cancer in the family. Ductal breast cancer was associated with having a mother diagnosed with cancer. There was a significant association between lobular breast cancer and having a father with prostate cancer, OR 2.4 (CI 1.1-5.3). The occurrence of having a father with prostate cancer for lobular breast cancer patients was higher in the younger patient group, OR 2.9 (CI 1.1-7.8), and was still high but lost statistical significance in the older patient group, OR 1.9 (CI 0.5-7.4). The association between lobular breast cancer and a father remained significant after excluding fathers with prostate cancer, OR 1.94 (CI 1.20-3.14). Other commonly occurring tumor types in the father included sarcoma and leukemia.ConclusionWe propose that lobular breast cancer is associated with having a father diagnosed with cancer, most commonly prostate carcinoma. Since the association remained after excluding family history of breast cancer, the association seems independent of classical breast cancer heredity. The association with a father diagnosed with cancer also remained after removing prostate cancer, indicating an independence from prostate cancer as well. The reason for this association is genetically unclear, but could involve sex-specific imprinting.

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Etiology of familial breast cancer with undetected BRCA1 and BRCA2 mutations: clinical implications

Yiannakopoulou

2013

Cell Oncol.

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Current evidence suggests that in the majority of cases with BRCA1 and BRCA2 negative familial breast cancer the etiology is due to interactions of intermediate or low risk alleles with environmental and lifestyle factors. Thus, a careful selection of patients submitted to genetic testing is needed. Clearly, further research is required to fully elucidate the etiology of non-BRCA familial breast cancer.

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Can a phenotype for recessive inheritance in breast cancer be defined?

Cited by 4 publications

References 16 publications

Autoimmune diseases and hypersensitivities improve the prognosis in ER-negative breast cancer

Autoimmune diseases and hypersensitivities improve the prognosis in ER-negative breast cancer

Breast cancer patients with lobular cancer more commonly have a father than a mother diagnosed with cancer

Etiology of familial breast cancer with undetected BRCA1 and BRCA2 mutations: clinical implications

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