“…The poor neurological outcome following CPR in the context of PE can be explained as follows: the obstruction of the pulmonary arteries induces, on the one hand, the decrease in the effectiveness of cardiac massage, reducing the transpulmonary flow, the preload left ventricular and therefore cardiac output and cerebral perfusion, and, on the other hand, an increase in central venous pressure that induces a decrease in cerebral blood return [ 6 ], an increase in cerebral blood volume and therefore a higher intracranial pressure [ 7 ]. In parallel, PE induces a disorder of haematosis that also aggravates cerebral hypoxia [ 7 ]. Therefore, it appears essential that CPR be started immediately and that the implantation of ECMO be as rapid as possible, shortening the low-flow time to its minimum [ 8 ].…”