Can 5‐year‐olds sensibly self‐report the impact of developmental enamel defects on their quality of life?

Srinivasan, Samuel Raj

doi:10.1111/ipd.12662

Cited by 60 publications

(54 citation statements)

References 9 publications

(6 reference statements)

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“…Computational tools have long been used for the purpose of rapid identification of these potential targets from several sources [29][30]. Dental caries being a serious illness in children has to be identified at the right time and treated using drugs that do not give rise to resistant forms [31][32][33][34]. Hence, proper identification of the potential targets has become the need of the hour.…”

Section: Resultsmentioning

confidence: 99%

Virtual Screening to Identify the Protein Network Interactions of Triclosan with Streptococcus mutans and Enterococcus faecalis

Hariprasanth

Priyadharsini

Girija

et al. 2021

JPRI

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Introduction: Triclosan is considered to be an important ingredient in toothpastes and mouth rinses. Several studies have reported contradictory results regarding the antimicrobial effect of triclosan. Hence, the present in silico study intends to identify the potential targets of triclosan in two common dental pathogens Streptococcus mutans and Enterococcus faecalis. Aim: To identify the protein network interactions of triclosan in Streptococcus mutans and Enterococcus faecalis by virtual screening method. Materials and Methods: The STITCH v5.0 database was initially used for identifying drug-protein interactions followed by VICMPred and VirulentPred which was employed to identify functional class of the proteins and its virulence property. Finally, BepiPred v1.0 Linear Epitope Prediction tool was used to identify the potential epitopes of the virulent proteins. Results: Triclosan was found to interact with crucial proteins in S. mutans and E. faecalis which could contribute to severe forms of periodontitis and endodontic diseases. Conclusion: Taken together, the present study provides the preliminary data on the potential targets of triclosan in common dental pathogens. Further experimental validation is warranted to provide concrete evidence on the molecular targets of dental pathogens.

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Section: Resultsmentioning

confidence: 99%

Virtual Screening to Identify the Protein Network Interactions of Triclosan with Streptococcus mutans and Enterococcus faecalis

Hariprasanth

Priyadharsini

Girija

et al. 2021

JPRI

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“…In line with these facts, berberine was chosen for the study to identify its potential targets in red complex pathogens. Our research team has embarked on identifying the potential molecular targets of different plant compounds against dental pathogens with a special emphasis on periodontal pathogens and emerging drug resistant species [22][23][24][25][26][27][28][29][30][31][32][33][34].…”

Section: Resultsmentioning

confidence: 99%

Virtual Screening to Identify the Protein Network Interaction of Berberine with Red Complex Pathogens

Abinaya

Priyadharsini

Girija

et al. 2021

JPRI

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Introduction: Periodontal disease is an infection of the tissues that hold your teeth in place. It's typically caused by poor brushing and flossing habits that allow plaque, a sticky film of bacteria, to build up on the teeth and harden. Elimination of these pathogens from the site of infection remains a perplexing task, which demands the use of antibiotics. The emergence of drug resistant forms has spurred interest into identifying novel therapeutic targets against these pathogens. Aim: The present study employs virtual screening method to identify the protein network interaction of berberine with red complex pathogens. Materials and Methods: Computational tools were used to identify the targets, assess their functional role and virulence property. Further, the peptide epitopes present in the virulence factors were identified using the BepiPred tool. The subcellular location of the virulence proteins was also elucidated using PSORTb. Results: Berberine was found to target vital protein transporters such as TetR family transcriptional regulator and MerR family transcriptional regulator, which is known to play a crucial role in the survival of bacterial cells. Conclusion: Hence the present study provides preliminary data on the protein targets of berberine against red complex pathogens. However, in vitro studies using the compound is warranted to further confirm the efficacy of the compound.

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“…Our institution is passionate about high quality evidence based research and has excelled in various fields [27][28][29][30][31][32][33][34][35][36][37].…”

Section: Discussionmentioning

confidence: 99%

Effectiveness Of Anti-Inflammatory Properties Of Combination Of Bromelain,Trypsin And Rutoside With Combination Of Diclofenac And Serratiopeptidase Following Surgical Removal Of Impacted Mandibular Third Molar- A Randomised Double Blinded Clinical Trial

Muthusekhar¹

2021

IJDOS

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Can 5‐year‐olds sensibly self‐report the impact of developmental enamel defects on their quality of life?

Cited by 60 publications

References 9 publications

Virtual Screening to Identify the Protein Network Interactions of Triclosan with Streptococcus mutans and Enterococcus faecalis

Virtual Screening to Identify the Protein Network Interactions of Triclosan with Streptococcus mutans and Enterococcus faecalis

Virtual Screening to Identify the Protein Network Interaction of Berberine with Red Complex Pathogens

Effectiveness Of Anti-Inflammatory Properties Of Combination Of Bromelain,Trypsin And Rutoside With Combination Of Diclofenac And Serratiopeptidase Following Surgical Removal Of Impacted Mandibular Third Molar- A Randomised Double Blinded Clinical Trial

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