Camu‐camu (<i>Myrciaria dubia</i>) from commercial cultivation has higher levels of bioactive compounds than native cultivation (Amazon Forest) and presents antimutagenic effects <i>in vivo</i>

Azevedo, Luciana; Ribeiro, Pedro; Oliveira, Jéssica A.; Correia, Maryana G; Ramos, Flávia Maria de Moraes; Oliveira, Eduardo Basílio de; Barros, Frederico Augusto Ribeiro de; Stringheta, Paulo César

doi:10.1002/jsfa.9224

Cited by 32 publications

(34 citation statements)

References 43 publications

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“…The mutagenicity of the AcOET fraction was evaluated using the bone marrow micronucleus test as described in Azevedo et al. (). The in vivo gut micronucleus test was performed according to Silva et al.…”

Section: Methodsmentioning

confidence: 99%

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Sclerotinia Sclerotiorum (White Mold): Cytotoxic, Mutagenic, and Antimalarial Effects In Vivo and In Vitro

Pressete

Giannini

Paula

et al. 2019

Journal of Food Science

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This work aimed includes performing the sclerotia chemical profile and evaluates their biological effects on mutagenesis, oxidative stress, cancer, and malaria. A chemical profile was determined by ultraperformance liquid chromatography mass spectrometry (UHPLC-HRMS) analysis dereplicating norditerpenoid dilactone, sclerolide, and other compounds. The GI 50 values to cancer cells (19.8 to 277.6 µg/mL) were higher than normal (16.05 µg/mL), meaning high cytotoxicity. Regarding the oxidative stress, the results showed that the all AcOET fraction concentrations tested on IMR90 noncancer cell increased reactive oxygen species (ROS) production in more intense way (by fivefold) than in tested cancer cells. The in vivo study showed an increase of the following biomarkers (by 296.00%): % DNA in comet tail in peripheral blood and liver cells; micronucleated erythrocytes and colon cells and lipid serum peroxidation.These results indicate the sclerotia as genotoxic and mutagenic agent and its contamination may lead to fungal toxic effects with a risk to human health.

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Section: Methodsmentioning

confidence: 99%

“…The peripheral blood and liver comet assay were executed, as described in (Azevedo et al., ). The fluorescent labeled DNA was visualized using a Nikon Eclipse 80i fluorescence microscope at 200 × magnification, with a green filter.…”

Section: Methodsmentioning

confidence: 99%

Sclerotinia Sclerotiorum (White Mold): Cytotoxic, Mutagenic, and Antimalarial Effects In Vivo and In Vitro

Pressete

Giannini

Paula

et al. 2019

Journal of Food Science

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“…The discovery and investigation of compounds that possess antimutagenic properties, have been of great importance, since it is estimated that 75-85% of all chronic diseases linked to lifestyle, and these compounds can reduce the rate of mutation, and consequently, the incidence of cancer and other diseases resulting from changes in the genetic material (De Flora & Ramel, 1998;Wong et al, 2005;Durnev, 2018;Malik et al, 2021). Studies show that plant-derived compounds such as vitamins, carotenoids, flavonoids, polyphenols, sesquiterpenoids, α-linolenic acid, coumarins, among others, may act as mutagenesis inhibitors (Weisburger, 2001;Veiga Junior & Pinto, 2002;Ferguson & Philpott, 2004;Majolo et al, 2019;Azevedo et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

Antimutagenic effects of copaiba oils (Copaifera langsdorffii Desf.) and flaxseed (Linum usitatissimum L.) against the clastogen – cyclophosphamide, in Wistar rat

Heck

Yoshimoto-Higaki

Godoy

et al. 2022

RSD

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Copaiba oil extracted from the trunk of Copaifera langsdorffii Desf. and flaxseed oil extracted from the seeds of Linum usitatissimum L., are widely used for the prevention and treatment of many diseases, including cancer. The aim of this study was to assess the antimutagenic effect of these oils against the damage-inducing agent cyclophosphamide, in Rattus norvegicus treated in vivo, by gavage, using cytotoxicity and chromosomal alteration test. The animals were submitted to a single dose of copaiba oil and of flaxseed oil in the simultaneous treatment, pre-treatment and pos-treatment for 24 hours. None of these treatments presented cytotoxic effect. Treatments both oils and cyclophosphamide have significantly reduced the chromosomal damage caused by the clastogen. In groups treated with copaiba oil the reduction percentage was 77% for the simultaneous treatment, 83% for the pre-treatment and 75% for the pos-treatment, whereas in those treated with flaxseed oil was 94% for the pre-treatment and 96% for the simultaneous and pos-treatment. These results indicate that the both oils are not mutagenic, in contrast, they present antimutagenic activity against this clastogenic agent, which represents a protective effect on the cells against the drug that has damaged the genetic material.

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“…Myrciaria dubia has attracted a lot of attention because of its remarkable quantity of bioactive compounds [6]. Especially because of their antioxidant activity, their fruits have been used for functional food production, including an artisanal beer with high ascorbic acid concentration [7].…”

Section: Introductionmentioning

confidence: 99%

Yeasts with Fermentative Potential Associated with Fruits of Camu-Camu (Myrciaria dubia, Kunth) from North of Brazilian Amazon

Matos

Andrade-Souza

D’Angelo

et al. 2021

The Scientific World Journal

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Considering the high biotechnological potential of yeasts associated to edible fruits, a screening for these microorganisms, capable of alcoholic fermentation, was performed in ripe fruits of camu-camu (Myrciaria dubia, Kunth). The fruits were collected from north of Brazilian Amazon, in the floodplain of the Cauamé River. Yeasts were isolated, and fermentation capability was evaluated using Durham tubes. Quantitative assays were performed to calculate ethanol yield (g g−1), specific growth rate (h−1), and ethanol productivity (g L−1·h−1). Taxonomic identification was performed by ribosomal gene nucleotide sequence analysis by alignment using BLASTN. A total of fifteen yeast colonies were isolated, and three of them presented promising ability to ferment glucose to ethanol. These isolates were identified as Candida orthopsilosis, Pichia kudriavzevii, and Meyerozyma caribbica. When cultured in broth containing 180 g·L−1 of glucose, M. caribbica CC003 reached 91.7 percent of the maximum theoretical ethanol concentration (84.4 g·L−1), presenting an ethanol yield and productivity of 0.4688 g·g−1 and 0.781 g·L−1·h−1, respectively. These results indicate a promising potential of this isolate for bioprocess applications. This paper is a rare report of C. orthopsilosis with endophytic habit because most of the references indicate it as a human pathogen. Besides this, M. caribbica is a promising fermenter for alcoholic beverages due to its osmotolerance and high ethanol yield. This is the first paper reporting endophytic yeasts associated with fruits of Myrciaria dubia.

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Camu‐camu (Myrciaria dubia) from commercial cultivation has higher levels of bioactive compounds than native cultivation (Amazon Forest) and presents antimutagenic effects in vivo

Abstract: The results of this study contribute to increasing the production of camu-camu fruits grown in dry environments and their use as a health-promoting food. © 2018 Society of Chemical Industry.

Cited by 32 publications

References 43 publications

Sclerotinia Sclerotiorum (White Mold): Cytotoxic, Mutagenic, and Antimalarial Effects In Vivo and In Vitro

Sclerotinia Sclerotiorum (White Mold): Cytotoxic, Mutagenic, and Antimalarial Effects In Vivo and In Vitro

Antimutagenic effects of copaiba oils (Copaifera langsdorffii Desf.) and flaxseed (Linum usitatissimum L.) against the clastogen – cyclophosphamide, in Wistar rat

Yeasts with Fermentative Potential Associated with Fruits of Camu-Camu (Myrciaria dubia, Kunth) from North of Brazilian Amazon

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