Campylobacter-Uke Organisms in the Stomach of Patients and Healthy Individuals

Langenberg, M. L.; Tytgat, G. N. J.; Schipper, Maria; Rietra, P. J. G. M.; Zanen, H. C.; Burnett, R A; Forrest, J. A. H.; Girdwood, R. W. A.; Fricker, C. R.

doi:10.1016/s0140-6736(84)91836-1

Cited by 244 publications

(96 citation statements)

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“…This may be attributed to the role which might be played by the occupation, personal habits and/or stress. Langenbert et al [18], reported an increased risk of infection with HP with increase of age. The frequencies of symptoms among our cases were discomfort after meals, a sensation of fullness, distention, heartburn, eructation and nausea, respectively.…”

Section: Discussionmentioning

confidence: 98%

Association of Helicobacter Pylori and Nonulcer Dyspepsia

Darwish

1992

Ann Saudi Med

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The etiology and pathogenesis of nonulcer dyspepsia (NUD) are not completely understood and consequently, no specific medication can be prescribed to the sufferers. We studied 69 cases, proved clinically, laboratorally, sonographically and endoscopically, to have NUD. Antral biopsy was taken from every case and subjected to CLO test. Out ofthe 69 patients, 51 (74%) were infected with Helicobacter pylori (HP). Oral medication, consisting of amoxacillin 500 mg, metronidazol 500 mg, and bismuth mixture, 5 mis three times daily was prescribed for four weeks. Out of the 51 patients at the end of four weeks, 46 cases (90%) were cleared of HP, and only 38 cases (74.5%) experienced complete improvement of their dyspeptic symptoms. We arrived at the conclusion that a good percentage of NUD patients can be cured by the use of the 3-drug combination. AA Darwish, Association of Helicobacter Pylori and Nonulcer Dyspepsia. 1992; 12(1): 83-87Dyspepsia is commonly experienced as a transient unpleasant sensation in the epigastrium. Once in their lives approximately 10% of the population experience more serious and prolonged upper abdominal discomfort relating to food which is usually relieved by antacids [1]. Likewise symptoms may compel the patient to seek medical advice where a diagnosis can be made with endoscopy which may reveal an ulcer or nonulcer dyspepsia.A very interesting recent development in ulcer field has been the rediscovery of HP by Warren and Marshall in 1983 [2], in the gastric mucosa of patients suffering from gastritis. Several studies since then have been conducted to investigate the relationship between HP and peptic ulcer disease [3][4][5]. It has been found that HP causes type B chronic active gastritis [1,6]. Helicobacter pylori has also been implicated in the etiology of NUD [7,8].Helicobacter pylori is a curved gram-negative bacillus with unipolar two to six flagella that provides motility. It is found close to the gastric epithelium beneath a thin layer of mucus which separates it from the lethal acidic gastric interior. Again, it produces a protective cloud of alkali around itself, since it releases potent urease that splits gastric juice urea into one molecule of CO2 and two of ammonia with net production alkali [6]. At present, it is not known how the organism is transmitted from one person to another and no natural reservoir has been identified.We conducted this study to disclose the HP role in inducing NUD. We also studied the effect of a combination of drug treatment for this condition. Material and MethodsThis study was conducted in King Fahad Hofuf Hospital between May and July, 1990. It comprised 69 patients suffering from dyspepsia and referred to esophagogastroduodenoscopy (ECD) from surgical and medical outpatient clinics. Patients were not included in the study if they were taking steroids, nonsteroid anti-inflammatory drugs, antibiotics, H2 blockers or antacids. A physical examination was performed on every patient. Laboratory studies included routine blood chemistry, liver enzymes and ...

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Section: Discussionmentioning

confidence: 98%

Association of Helicobacter Pylori and Nonulcer Dyspepsia

Darwish

1992

Ann Saudi Med

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“…We are now, however, in a position to investigate the importance of common attributes that have been suggested previously to be involved in colonisation, i.e., micro-aerophilic conditions, specialised motility and possession of large amounts of urease enzyme (Langenberg et al, 1984;Hazell et al, 1986;Lee and Hazell, 1988).…”

Section: Discussionmentioning

confidence: 99%

Use of the mouse for the isolation and investigation of stomach-associated, spiral-helical shaped bacteria from man and other animals

Dick

Lee

Watson

et al. 1989

Journal of Medical Microbiology

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Summary. Spiral-helical shaped bacteria other than Carnpylobacter pylori have been shown to infect the human stomach. The characteristic helical morphology of these bacteria appears to be similar to that of bacteria found in the stomachs of many other animal species. Early reports on gastric bacteria suggested that rodents may be useful for investigation and isolation of stomach-associated bacteria. Therefore, anaesthetised mice were given, through a stomach tube, a heavy suspension of a spiral-helical bacterium from a cat, scrapings of gastric mucus from primates, or a homogenised whole-antral biopsy from a human patient. At intervals after inoculation, gastric biopsies were examined by lightmicroscopy and electronmicroscopy for the presence of spiral-helical bacteria. Significant colonisation was observed in 40% of mice 1 week, and in 80% of mice 1 1 weeks, after inoculation with suspensions of the cat isolate. Mice were also successfully colonised by spiral bacteria present in homogenised human biopsy material and by other spiral bacteria from a monkey. These observations suggest that mice may prove to be useful animals for the study of gastric bacteria that are, as yet, non-cultivable and for analysis of some of the attributes commonly thought to be involved in colonisation.

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“…Recent work has identified Campylobacter pylori in the gastric muwsa of normal controls, patients with type-B chronic gastritis, and patients with peptic ulceration (Jones et al, 1984;Langenberg et al, 1984;McNulty and Watson 1984). There has been debate as to the role of the organism in upper gastrointestinal pathology (Rathbone et al, 1986).…”

Section: Introductionmentioning

confidence: 99%

“…Relapse following the treatment of duodenal ulceration has been linked to the re-isolation of C. pylori from biopsy material (Coghlan et al, 1987). However, C. pylori has been isolated from asymptomatic, healthy medical students (Langenberg et al, 1984) and serological studies, with partially purified and extracted material from C. pylori as antigen, showed that there was no correlation between the extent of mucosal colonisation with C. pylori and the pattern of antibody response detected by ELISA or immunoblotting (Jones et al, 1986;Steer et al, 1987).…”

Section: Introductionmentioning

confidence: 99%