Campylobacter Pylori, Non-Ulcer Dyspepsia, and Race in Malaysia

Nafeeza, M. I.; Shahimi, M. M.; Kudva, M V; Mazlam, M. Z.; Isa, M R

doi:10.1016/s0140-6736(89)92660-3

Cited by 5 publications

(1 citation statement)

References 3 publications

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“…The prevalence of H. pylori infection varies among different ethnic groups. The Indians have the highest prevalence of infection of about 68.9–75.0%, the Chinese ranging from 45.0% to 60.6%, and the Malays of about 8–43.3%[2–4]. In Malaysia, gastric cancer occurs highest among the Chinese (68.0%) followed by the Indians (16.5%) and Malays (15.5%) [5].…”

Section: Introductionmentioning

confidence: 99%

cagAgene variants in MalaysianHelicobacter pyloristrains isolated from patients of different ethnic groups

Rosmawati

Aminuddin

Hanafiah³

et al. 2005

FEMS Immunology &Amp; Medical Microbiology

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Helicobacter pylori infection of a distinct subtype of cagA may lead to different pathological manifestation. The aim of this study is to determine the presence of cagA gene and its variants in H. pylori infection among different ethnic groups and its effect on gastroduodenal diseases. Overall detection of cagA among the 205 clinical isolates of H. pylori was 94%. Variations in size of the 3' region of cagA gene were examined among 192 Malaysian H. pylori cagA-positive strains. Results showed that three cagA variants differing in fragment length of PCR products were detected and designated as type A (621-651bp), type B (732-735bp) and type C (525 bp). Although there was no association between any of the cagA subtypes with peptic ulcer disease (p>0.05), an association between cagA subtypes with a specific ethnic group was observed. Specific-cagA subtype A strains were predominantly isolated from Chinese compared to Malays and Indians (p<0.0005), and cagA subtype B strains were predominantly isolated from Malays and Indians compared to Chinese (p<0.05). The cagA type A strains of H. pylori is commonly found in the Chinese patients who have a higher risk of peptic ulcer disease, thus indicating that it could be used as an important clinical biomarker for a more severe infection.

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Section: Introductionmentioning

confidence: 99%