Campylobacter-like organisms in Meckel's diverticulum?

Loffeld, R. J. L. F.; Loffeld, B. C. A. J.; Arends, J. W.

doi:10.1136/jcp.42.10.1111-a

Cited by 7 publications

(4 citation statements)

References 1 publication

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“…In reviewing all the reported series of Meckel’s diverticulum, including the present one, a total of 232 cases with heterotopic gastric mucosa had been reported 11 –15 , 10 –26 (Table 1). Only in 11 cases (4%) were H. pylori ‐like organisms identified 10 –14 .…”

Section: Discussionmentioning

confidence: 96%

Helicobacter pylori in Meckel’s diverticulum with heterotopic gastric mucosa in a population with relatively high H. pylori prevalence rate

Chan

Yuen

Chu

et al. 1999

J of Gastro and Hepatol

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Section: Discussionmentioning

confidence: 96%

Helicobacter pylori in Meckel’s diverticulum with heterotopic gastric mucosa in a population with relatively high H. pylori prevalence rate

Chan

Yuen

Chu

et al. 1999

J of Gastro and Hepatol

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“…An example of a sampling bias from the present series could be the observation of peptic ulceration in a diverticulum with no oxynthic mucosa sampled. Most studies do not report with the age of the patients 21 : 13.6% and 32.1% of the present 140 Meckel's diverticula were resected in patients younger than 10 years, 20 years, respectively, and the proportions were 24% and 40% for diverticula containing gastric mucosa. The young age of the majority of patients with ectopic gastric tissue in the Meckel's diverticulum is in contrast to the prevalence of H pylori infection increases with age.…”

Section: Discussionmentioning

confidence: 99%

Gastric Pathology in Meckel’s Diverticulum:Review of Cases Resected Between 1965 and 1995

Cserni

1996

Am J Clin Pathol

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G a s t r i c P a t h o l o g y i n M e c k e l ' s D i v e r t i c u l u m Review of Cases Resected Between 1965 and1995 GABOR CSERNI, MDOne hundred forty-nine case files of Meckel's diverticulum resected at our hospital between 1965 and 1995 were reviewed for the presence of heterotopic gastric mucosa. Of these, 140 cases were evaluated, and 25 demonstrated ectopic gastric mucosa. Six of these heterotopic tissue specimens contained no assessable surface mucosa; therefore only 19 were evaluated for gastric histopathologic changes. "Gastritis" was present in all reviewed cases, but the predominant pattern was that of reflux-type gastritis or gastropathy, which had not previously been documented at this location. This gastropathy was demonstrated in 58% of the cases and could also account for some of the symptoms that prompted removal of appendixes without inflammation. Chronic and chronic active gastritis were also demonstrated in a minority of cases, and those with moderate or severe activity were associated with

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“…Our study is the first to focus on children, and specifically to compare patients with Meckel's diverticula who presented with or without symptomatic intestinal hemorrhage. Prior investigations of Meckel's diverticula and H. pylori that address the topic note clinical or histologic evidence of hemorrhage or ulceration in the minority of patients; however, gastric mucosa was present in only 203 of the 702 diverticula (29%) examined (10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20). Twelve diverticula from five of the prior analyses (11)(12)(13)16,19) had organisms suggestive of H. pylori.…”

Section: Discussionmentioning

confidence: 99%

“…H. pylori resides in the stomach of humans and primates (5), and has been identified in ectopic or metaplastic gastric mucosa outside the stomach (6-9) Previous investigations, studying predominantly adults, have produced conflicting results regarding the bacteria's presence in the gastric mucosa of Meckel's diverticulum (10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20). Because Meckel's diverticula in childhood are more likely than those discovered in adulthood to contain gastric mucosa, we focused on a pediatric population to determine whether H. pylori colonized the gastric epithelium of Meckel's diverticula and to determine its relationship to "gastritis", ulceration, bleeding, and intussusception.…”

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confidence: 99%

Helicobacter pylori and Meckel's Diverticula

Finn,

Christie

2001

J. pediatr. gastroenterol. nutr.

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BackgroundHelicobacter pylori is known to infect only gastric mucosa and is strongly associated with gastroduodenal ulceration. The authors studied whether H. pylori colonizes the gastric mucosa of Meckel's diverticula, and determined its relationship to “gastritis” and bleeding.MethodsA 10‐year retrospective review identified 45 children with Meckel's diverticulum. Hematoxylin–eosin and Diff‐Quik stains were used to assess the presence and severity of gastritis, and to highlight organisms in the resected diverticula. Cases with organisms were then studied with antibodies specific for H. pylori using immunoperoxidase methods.ResultsTwenty‐eight children, 7 months to 12.6 years of age, had lower gastrointestinal hemorrhage caused by Meckel's diverticulum and had positive radionuclide scans. All had acid‐secreting mucosa in their diverticula, and ulceration. “Chronic gastritis” and eosinophilia were constant findings; “acute gastritis” was present in four patients. Twenty specimens exhibited lymphoid follicles in the gastric mucosa. Seventeen patients with Meckel's diverticula (age range, 1 month–14.7 years) who presented with acute abdominal pain associated with intussusception were used for comparison. Acid‐secreting gastric mucosa was seen in four patients. H. pylori was identified in only one of the 45 patients; this patient had ulceration and moderate “acute gastritis.”ConclusionsH. pylori does not colonize a substantial number of children who have ulcerated and bleeding Meckel's diverticulum in the presence of acid‐secreting mucosa. Although H. pylori is a notable cause of ulceration, the authors confirm that ulceration is possible in its absence, and alternative mechanisms of ulceration are important. The presence of lymphoid follicles in Meckel's diverticula, unlike gastric biopsies, is not associated with H. pylori.

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Campylobacter-like organisms in Meckel's diverticulum?

Cited by 7 publications

References 1 publication

Helicobacter pylori in Meckel’s diverticulum with heterotopic gastric mucosa in a population with relatively high H. pylori prevalence rate

Helicobacter pylori in Meckel’s diverticulum with heterotopic gastric mucosa in a population with relatively high H. pylori prevalence rate

Gastric Pathology in Meckel’s Diverticulum:Review of Cases Resected Between 1965 and 1995

Helicobacter pylori and Meckel's Diverticula

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