Campylobacter fetus bacteraemia in a healthy individual: clinical and therapeutical implications

Zonios, Dimitrios I.; Panayiotakopoulos, Georgios; Kabletsas, Eleytherios O.; Tzima, Eystathia L.; Stefanou, Ioanna; Archimandritis, Athanasios

doi:10.1016/j.jinf.2004.08.023

Cited by 20 publications

(15 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Human immunodeficiency virus infection, alcoholism, cirrhosis, old age, pregnancy, diabetes mellitus, malignancies, beta-thalassemia, systemic lupus erythematosus, inherited immunodeficiencies, transplantation and splenectomy have all been recognized as important risk factors for the development of serious C . fetus infection [5,6]. In our patient, diabetes mellitus and myelodysplasia could have been contributing factors to the severe pacemaker pocket infection and bacteremia.…”

Section: Discussionmentioning

confidence: 85%

See 1 more Smart Citation

Campylobacter fetus infection presenting with bacteremia and cellulitis in a 72-year-old man with an implanted pacemaker: a case report

et al. 2012

View full text Add to dashboard Cite

Introduction: Campylobacter is an important causative agent of intestinal infections in humans. Bacteremia is detected in less than 1% of patients, mainly in immunocompromised patients and in extreme age groups. Cellulitis is a relatively common manifestation of Campylobacter infection, but concomitant bacteremia is a rare event.Infections of the pacemaker area are caused primarily by staphylococci, followed by fungi, streptococci and Gram-negative rods. To the best of our knowledge, this is the first case report of pacemaker pocket infection and bacteremia caused by Campylobacter fetus. Case presentation: A 72-year-old Croatian Caucasian man with myelodysplasia, impaired fasting glucose levels and a recently implanted permanent pacemaker was admitted to hospital after six days of fever, development of red swelling of the pacemaker pocket area and worsening of his general condition. No antibiotic therapy was introduced in the outpatient setting. He denied any recent gastrointestinal disturbances. With the exception of an elevated leukocyte count, erythrocyte sedimentation rate, and C-reactive protein and blood glucose levels, other laboratory findings were normal. Treatment with vancomycin plus netilmicin was introduced, and a surgical incision with drainage of the pacemaker pocket was performed. The entire pacemaker system was removed and a new one re-implanted after 14 days of antibiotic therapy. Transesophageal echocardiography showed no pathological findings. Three subsequent blood cultures obtained on admission as well as swab culture of the incised pacemaker area revealed Campylobacter fetus; stool and pacemaker lead cultures were negative. According to the microbiological results, antibiotic therapy was changed to ciprofloxacin plus netilmicin. A clinical examination and the results of a laboratory analysis performed after two weeks of therapy were within normal limits. Conclusion: Myelodysplasia, impaired fasting glucose levels and older age could be contributing factors for the development of bacteremic Campylobacter fetus cellulitis. Emergent surgical and antibiotic treatment are mandatory and provide the optimal outcome for such types of pacemaker pocket infection.

show abstract

Section: Discussionmentioning

confidence: 85%

“…fetus has been recognized as the major causative agent of extraintestinal infections. Cellulitis is a relatively common manifestation of Campylobacter infection but concomitant bacteremia is rare [6]. Infections of the pacemaker area are primarily caused by staphylococci, followed by fungi, streptococci and Gram-negative rods [7].…”

Section: Introductionmentioning

confidence: 99%

Campylobacter fetus infection presenting with bacteremia and cellulitis in a 72-year-old man with an implanted pacemaker: a case report

et al. 2012

View full text Add to dashboard Cite

show abstract

“…C. fetus subsp. fetus is most frequently related to human infections causing several types of diseases (14,22). The host specificity of C. fetus subsp.…”

mentioning

confidence: 99%

Two Novel Antibiotic Resistance Genes, tet (44) and ant(6)-Ib , Are Located within a Transferable Pathogenicity Island in Campylobacter fetus subsp. fetus

Abril¹,

Brodard²,

Perreten

2010

Antimicrob Agents Chemother

View full text Add to dashboard Cite

New tetracycline and streptomycin resistance genes, tet(44) and ant(6)-Ib, were identified in Campylobacter fetus subsp. fetus within a transferable pathogenicity island that is typically unique to Campylobacter fetus subsp. venerealis. The 640-amino-acid tetracycline resistance determinant, Tet 44, belongs to a class of proteins that confers resistance to tetracycline and minocycline by ribosomal protection. The 286-amino-acid streptomycin resistance determinant, ANT(6)-Ib, belongs to a family of aminoglycoside nucleotidyltransferases. The resistance phenotypes were demonstrated by gene inactivation and expression.

show abstract

“…Hemorrhages are not necessarily associated with all cases of enteritis induced by campylobacteria. Recent studies revealed that clinically manifest campylobacteriosis occurs in newborn children and patients with immunodeficiency syndrome, as well as in all diseases or syndromes associated with immune system impairment (HIV infection, liver cirrhosis, ageing, pregnancy, diabetes mellitus, malignant diseases, autoimmune diseases, transplantation, splenoectomy) (Zonios et al, 2004).…”

Section: Resultsmentioning

confidence: 99%

“…Results of recent studies revealed that campylobacter infections mostly affect the newborns and children, as well as patients with an immune deficiency syndrome or malignant diseases of the immune system. Furthermore, the infections frequently occur in patients with diabetes and alcoholics (Zonios et al, 2004). Investigation of diarrhea in animals revealed that, besides the campylobacteria, the decreased levels of gamma globulin significantly contributes to such clinical condition.…”

Section: Introductionmentioning

confidence: 99%

Effects of some immunosuppressive factors on campylobacteriosis outbreaks in poultry

Stojanov¹,

Milić²,

Ašanin³

et al. 2008

Acta vet. (Beogr.)

View full text Add to dashboard Cite

Campylobacteria are widely distributed in domestic and wild animals. Avian species are the most common host of campylobacteria, thus an important source for human infection caused by this organism. Campylobacteriosis in animals frequently proceeds without clinical symptoms, which may be due to the different virulence of the agent, as well as to the immune status of the infected animal. In this trial we investigated the effects of the vaccine against infective bursal disease (IBD) on occurrence and clinical manifestation of campylobacteriosis in conditions of controlled experimental infection with the strain Campylobacter jejuni. The immunosuppressive effects of a live attenuated vaccine against IBD on development of clinically manifest campylobacteriosis in perorally challenged chickens were assessed. The investigation was performed on 90 chickens in experimental conditions. The presence of Campylobacter jejuni was confirmed by reisolation, while identification of the organism was performed on the basis of its morphological, cultural and biochemical characteristics. Specific antibody titer and humoral immune response to C. jejuni specific antibodies were monitored using the complement fixation reaction method. Clinical symptoms of the disease were observed in chickens infected with Campylobacter jejuni and vaccinated against infective bursal disease. Pathomorphological findings revealed changes in the intestines and liver, from which Campylobacter jejuni was isolated. C. jejuni specific antibodies were detected in the infected birds in the third week post infection, with titer values ranging from 1:4 to 1:16. Results of our research strongly imply an immunosuppressive effect of the IBD vaccine on development of campylobacteriosis, which is supported by the clinical and morphological findings, i.e. isolation of the agent and detection of specific antibodies.

show abstract

Campylobacter fetus bacteraemia in a healthy individual: clinical and therapeutical implications

Cited by 20 publications

References 31 publications

Campylobacter fetus infection presenting with bacteremia and cellulitis in a 72-year-old man with an implanted pacemaker: a case report

Campylobacter fetus infection presenting with bacteremia and cellulitis in a 72-year-old man with an implanted pacemaker: a case report

Two Novel Antibiotic Resistance Genes, tet (44) and ant(6)-Ib , Are Located within a Transferable Pathogenicity Island in Campylobacter fetus subsp. fetus

Effects of some immunosuppressive factors on campylobacteriosis outbreaks in poultry

Contact Info

Product

Resources

About