Campylobacter colitis presenting as inflammatory bowel disease with segmentai colonic ulcerations

Loss, Robert W.; Mangla, Jagdish C.; Pereira, Mark

doi:10.1016/0016-5085(80)90088-8

Cited by 55 publications

(12 citation statements)

References 7 publications

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“…46,47 Colonoscopic findings show segmental edema, loss of normal vascular pattern with ulceration, and patchy involvement of mucosa. 48 Most patients with mild or moderate C. jejuni enterocolitis show a self-limiting illness; therefore, the usage of antibiotics has been in question in these patients. Severely ill patients, especially debilitated or immunocompromised persons, appear to benefit from antibiotic therapy, and erythromycin or ciprofloxacin are the drugs of choice.…”

Section: Campylobacter Speciesmentioning

confidence: 99%

Bacterial hemorrhagic enterocolitis

2003

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Bacterial diarrhea can be classified into two clinical entities, noninflammatory diarrhea and inflammatory diarrhea syndromes. The latter type of diarrhea is characterized by bloody and puruloid mucus stool, and is often accompanied by fever, tenesmus, and severe abdominal pain. Pathogenic bacteria causing the inflammatory diarrhea syndrome include Salmonella, Vibrio, Shigella, enteroinvasive and enterohemorrhagic Escherichia coli, Campylobacter, Yersinia, Chlamydia, and Clostridium difficile. The pathologic changes in the inflammatory diarrhea syndrome range from a superficial exudative enterocolitis to a transmural enterocolitis with overt ulceration. This syndrome is also designated as bacterial hemorrhagic enterocolitis because of its usual manifestation by bloody diarrhea. The diagnostic approach needs information on the patient's age, travel history, epidemiological associations, sexual practice, and medical history, including usage of antibiotics. Bacterial information can be obtained by microscopic study, culture, and the identification of specific bacterial toxins. Flexible colonoscopy with biopsy is useful for the differentiation of bacterial hemorrhagic enterocolitis from idiopathic ulcerative colitis and ischemic colitis. Physicians should be familiar with the diagnostic modalities used to detect the specific pathogens causing hemorrhagic bacterial enterocolitis; namely, bacterial culture, serology, histology, and nucleic acid technologies.

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Section: Campylobacter Speciesmentioning

confidence: 99%

Bacterial hemorrhagic enterocolitis

2003

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“…Occasionally an acute hemorrhagic colitis is seen with clinical presentation, endoscopic appearance, and histopathology indistinguishable from acute UC (91)(92)(93)(94)(95). Segmental colitis may also be seen (96). Toxic megacolon has been associated with C. jejuni infection (97)(98)(99)(100).…”

Section: Campylobacter Jejunimentioning

confidence: 99%

Clinical evaluation and management of acute severe colitis

Blomberg

2007

Inflamm Bowel Dis

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“…An increased understanding of the processes governing the terminal release of PMN into the intestinal lumen has important clinical implications, as inflammatory infiltrates characterized by accumulations of PMNs within mucosal tissues are pathognomonic of both acute and chronic inflammatory conditions. Specifically, PMN accumulation and abscess formation within intestinal crypts at the apical epithelial surface are pathological features of multiple inflammatory disease processes of the intestine including ulcerative colitis (14), infectious colitis (15), and necrotizing enterocolitis (16). …”

Section: Introductionmentioning

confidence: 99%

Neutrophil Migration across Intestinal Epithelium: Evidence for a Role of CD44 in Regulating Detachment of Migrating Cells from the Luminal Surface

Brazil

Lee

Kolegraff

et al. 2010

The Journal of Immunology

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Summary The migration of polymorphonuclear leukocytes (PMN) across the intestinal epithelium is a histopathological hallmark of many mucosal inflammatory diseases including inflammatory bowel disease (IBD). The terminal transmigration step is the detachment of PMN from the apical surface of the epithelium and their subsequent release into the intestinal lumen. The current study sought to identify epithelial proteins involved in the regulation of PMN migration across intestinal epithelium at the stage where PMN reach the apical epithelial surface. A panel of antibodies reactive with IFNγ-stimulated T84 intestinal epithelial cells was generated. Screening efforts identified one mAb, GM35, which prevented PMN detachment from the apical epithelial surface. Microsequencing studies identified the GM35 antigen as human CD44. Transfection studies confirmed this result by demonstrating the loss of the functional activity of the GM35 mAb following attenuation of epithelial CD44 protein expression. Immunoblotting and immunofluoresence revealed the GM35 antigen to be an apically expressed v6 variant-exon containing form of CD44 (CD44v6). ELISA analysis demonstrated the release of soluble CD44v6 by T84 cells during PMN transepithelial migration (TEM). In addition, the observed release of CD44v6 was blocked by GM35 treatment supporting a connection between CD44v6 release and PMN detachment. Increased expression of CD44v6 and the GM35 antigen was detected in inflamed ulcerative colitis tissue. This study demonstrates for the first time that epithelial expressed CD44v6 plays a role in PMN clearance during inflammatory episodes through regulation of the terminal detachment of PMNs from the apical epithelial surface into the lumen of the intestine.

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Campylobacter colitis presenting as inflammatory bowel disease with segmentai colonic ulcerations

Cited by 55 publications

References 7 publications

Bacterial hemorrhagic enterocolitis

Bacterial hemorrhagic enterocolitis

Clinical evaluation and management of acute severe colitis

Neutrophil Migration across Intestinal Epithelium: Evidence for a Role of CD44 in Regulating Detachment of Migrating Cells from the Luminal Surface

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