Campylobacter Cholecystitis

Darling, W.M.; Peel, R. N.; Skirrow, M. B.; Mulira, A. E. J. L.

doi:10.1016/s0140-6736(79)92269-4

Cited by 34 publications

(21 citation statements)

References 5 publications

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“…In a study on the natural history of this infection in children, the clinical picture ranged from asymptomatic infections to secretory diarrhea and, less frequently, inflammatory diarrhea (4). Other clinical presentations of Campylobacter infection are meningitis (12), bacteremia (32), localized extraintestinal infections (5), and immunoreactive complications such as Guillain-Barré syndrome (17,24) and reactive arthritis (2). This wide range of clinical manifestations cannot be explained as pertaining only to the host's response; characteristics of the bacterial pathogen may contribute.…”

mentioning

confidence: 99%

Molecular Characterization of Invasive and Noninvasive Campylobacter jejuni and Campylobacter coli Isolates

Carvalho¹,

Ruíz-Palacios²,

et al. 2001

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Campylobacter jejuni is one of the most common causes of bacterial diarrhea worldwide and is the primary bacterial cause of food-borne illness. Adherence to and invasion of epithelial cells are the most important pathogenic mechanisms of Campylobacter diarrhea. Molecular characterization of invasive and noninvasive Campylobacter isolates from children with diarrhea and symptom-free children was performed by random amplified polymorphic DNA techniques (RAPD). A distinct RAPD profile with a DNA band of 1.6 kb was observed significantly more frequently among invasive (63%) than among noninvasive (16%) Campylobacter isolates (P ‫؍‬ 0.000005). The 1.6-kb band was named the invasion-associated marker (IAM). Using specifically designed primers, a fragment of 518 bp of the iam locus was amplified in 85% of invasive and 20% of noninvasive strains (P ‫؍‬ 0.0000000). Molecular typing with a PCR-restriction fragment length polymorphism assay which amplified the entire iam locus showed a HindIII restriction fragment polymorphism pattern associated mainly with invasive strains. Although cluster analysis of the RAPD fingerprinting showed genetic diversity among strains, two main clusters were identified. Cluster I comprised significantly more pathogenic and invasive isolates, while cluster II grouped the majority of nonpathogenic, noninvasive isolates. These data indicate that most of the invasive Campylobacter strains could be differentiated from noninvasive isolates by RAPD analysis and PCR using specific primers that amplify a fragment of the iam locus.

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confidence: 99%

Molecular Characterization of Invasive and Noninvasive Campylobacter jejuni and Campylobacter coli Isolates

Carvalho¹,

Ruíz-Palacios²,

et al. 2001

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“…The infrequency of identifying Campylobacter as a cause for cholecystitis may be due to its rarity as suggested by Darling et al who searched for Campylobacter in the bile of 280 patients with cholecystitis and grew Campylobacter species in none of the samples studied 7. However, because standard HPA advice for the culture of bile does not recommend selective nutrient plate culture at 42°C in microaerophilic conditions, and positive blood cultures are rare, there may be cases occurring when Campylobacter cholecystitis is missed or under treated.…”

Section: Discussionmentioning

confidence: 99%

Campylobacter jejuni cholecystitis: a rare but significant clinical entity

Vaughan-Shaw

Rees²,

White³

et al. 2010

Case Reports

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Cholecystitis caused by Campylobacter is rare with only 14 cases found in the literature. This case describes a 71-year-old man who presented with right hypochondrial abdominal pain due to a gangrenous gallbladder identified at laparotomy. Culture of a bile sample identified a slow-growing gram-negative bacterium identified as Campylobacter jejuni. After a poor clinical response, this identification allowed targeted antibiotic treatment resulting in a slow but successful recovery and discharge 17 days postoperatively. This case demonstrates the importance of considering rare organisms in severe acute cholecystitis and ensuring appropriate cultures are performed, particularly in those who fail to respond to initial antimicrobial treatment.

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“…However, histological lesions were not seen in the gall-bladder and bacteria could not be detected in sections of gall-bladder stained by Gram or by the Warthin-Starry silver impregnation technique. Blaser et al (1980) and Darling et al (1979) reported that C. jejuni can survive in the liver and bile ducts for some weeks and pass in the bile into the gall bladder, and from this site be intermittently excreted into the intestinal lumen and faeces. These events might also occur in human infection, particularly in the case of symptomless exeretors.…”

Section: Discussionmentioning

confidence: 99%

Experimental infection of Rhesus monkeys with a human strain ofCampylobacter jejuni

Fitzgeorge

Baskerville

Lander

1981

J. Hyg.

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SUMMARYYoung Rhesus monkeys (Macac mulatta) were infected orally with a human strain of Campylobacter jejuni. The disease induced was mild, with inappetence and diarrhoea of short duration, but prolonged intermittent excretion of the bacteria in the faeces occurred. Bacteraemia was generally present for 2-3 days and later the organisms localized in the liver and gall bladder. Recovered animals, when challenged with the same strain, showed no clinical symptoms, no bacteraemia, and excreted the organisms in the faeces for only 3 days.

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Campylobacter Cholecystitis

Cited by 34 publications

References 5 publications

Molecular Characterization of Invasive and Noninvasive Campylobacter jejuni and Campylobacter coli Isolates

Molecular Characterization of Invasive and Noninvasive Campylobacter jejuni and Campylobacter coli Isolates

Campylobacter jejuni cholecystitis: a rare but significant clinical entity

Experimental infection of Rhesus monkeys with a human strain ofCampylobacter jejuni

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