Camptothecin

Shamma, Maurice; Georgiev, Vassil St.

doi:10.1002/jps.2600630203

Cited by 36 publications

(15 citation statements)

References 49 publications

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“…HCPT is currently clinically used against gastric carcinoma, hepatoma, leukemia, and tumours of head and neck in China [5,6]. Apart from the initial isolation and identification of new CPTs and their in vitro antitumour activities [4,[7][8][9], few studies were carried out on MCPT due to its high toxicity [10]. MCPT also showed much higher cytotoxicity effect than HCPT against the ovarian cancer cell line 2 774 [11].…”

Section: A Simple Hplc Methods With Fluorescence Detection For Simultamentioning

confidence: 99%

A Simple HPLC Method with Fluorescence Detection for Simultaneous Determination of 10-methoxycamptothecin and its Metabolite 10-hydroxycamptothecin in Rat Liver Tissue

et al. 2014

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A simple HPLC method to determine the amount of 10-methoxycamptothecin (MCPT) and its major metabolite 10-hydroxycamptothecin (HCPT) in rat liver tissue was developed in the present study. Camptothecin (CPT) was used as internal standard (IS). A piecewise linear function was used over lower and higher concentrations, respectively. The calibration curves were linear (r (2) >0.99) over concentrations from 2.5 to 20 ng/mL and 20 to 320 ng/mL for both MCPT and HCPT. The method had an accuracy of 92.74% to 112.76%, and the intra- and inter-day precision (RSD%) were 11.85% or less for MCPT and HCPT. The stability data showed no significant degradation occurred under the experimental conditions. This method was successfully applied to the tissue distribution study of MCPT and its metabolite HCPT in liver tissue samples after intravenous administration.

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Section: A Simple Hplc Methods With Fluorescence Detection For Simultamentioning

confidence: 99%

A Simple HPLC Method with Fluorescence Detection for Simultaneous Determination of 10-methoxycamptothecin and its Metabolite 10-hydroxycamptothecin in Rat Liver Tissue

et al. 2014

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“…Two articles gave the current status of prostaglandins as potentially useful drugs (19,20). Various properties of camptothecin were reviewed including synthesis, structure, and pharmacological activity (21). The pharmaceutical uses of polymers, both water soluble and insoluble, were discussed (22), and the characteristics and uses of gelatin in pharmacy and medicine were presented (23).…”

Section: General Pharmacymentioning

confidence: 99%

Pharmaceutical Sciences—1974: Literature Review of Pharmaceutics

Haleblian¹,

Goodhart²

1975

Journal of Pharmaceutical Sciences

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“…HCPT is currently clinically used against gastric carcinoma, hepatoma, leukemia, and tumors of head and neck in China [8,9]. Apart from the initial isolation and identification of new CPTs and their in vitro antitumor activities [4,[12][13][14], few studies were carried out on MCPT due to its higher toxicity [15]. To elucidate the potential of MCPT in the development of new anticancer drugs, we tested its antitumor activity against 2774, an ovarian cancer cell line, and MCPT showed higher cytotoxicity than HCPT.…”

Section: Introductionmentioning

confidence: 99%