CAMPATH-1M T-cell depleted BMT for SCID: long-term follow-up of 19 children treated 1987–98 in a single center

Single centre experience of umbilical cord stem cell transplantation for primary immunodeficiency

“…Comparison of our cohort of patients undergoing UCSCT compares favourably with previously published data on the outcome of transplantation using haplo-identical T-cell depleted marrow. In our historical published series of SCID patients receiving marrow stem cells, depleted of T cells using CAMPATH-1 M and complement, 49% of 37 transplant episodes achieved engraftment, with 63% survival overall, 20 compared to 86% survival and cure in this report. Our current results also compare favourably with published pooled European data on the outcome of HLA-mismatched transplants for SCID between 1996 and 1999, with a survival of 77%.…”

A novel reduced-intensity stem cell transplant regimen for nonmalignant disorders

“…Both bacterial infections that resulted in mortality were detected just prior to transplant, a complication previously described. 45 The third patient succumbed to CMV infection despite initial gancyclovir and later foscarnet therapy. The CMV isolated from this patient was found to carry a UL 937 mutation, accounting for resistance to treatment.…”

Long-term outcomes of nonconditioned patients with severe combined immunodeficiency transplanted with HLA-identical or haploidentical bone marrow depleted of T cells with anti-CD6 mAb

“…2,6 Several variables could explain these differences, such as the diversity of SCID phenotypes, timing of the transplant, infection status of the patient, and potential toxicity of conditioning regimens. 2,6 Several mAbs have been used for T-cell depletion of bone marrow grafts, [21][22][23][24][25][26][27] but use of anti-CD6 mAb for T-cell depletion of bone marrow in HSCT in a large series of patients with SCID and their long-term outcomes has not been previously reported. We reviewed the records of 25 consecutive patients with the diagnosis SCID who underwent BMT at a single center over a 15-year period (1981-1995) and describe the long-term outcomes (range, 10-27 years) of these patients.…”