Abstract:In the ileum of the brushtail possum, Trichosurus vulpecula, fluid secretion appears to be driven by electrogenic HCO secretion. Consistent with this, the cystic fibrosis transmembrane conductance regulator is expressed in the apical membrane of the ileal epithelial cells and the pancreatic or secretory variant of the NaHCO cotransporter in the basolateral membrane. This suggests that in the possum ileum, electrogenic HCO secretion is driven by basolateral NaHCO cotransporter (NBC) activity. To determine if th… Show more
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