CaMKII is essential for the cellular clock and coupling between morning and evening behavioral rhythms

Kon, Naohiro; Yoshikawa, Tomohiro; Honma, Sato; Yamagata, Yoko; Yoshitane, Hikari; Shimizu, Kimiko; Sugiyama, Yasunori; Hara, Chihiro; Kameshita, Isamu; Honma, Ken‐ichi; Fukada, Yoshitaka

doi:10.1101/gad.237511.114

Cited by 59 publications

(87 citation statements)

References 48 publications

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“…CIPKs decode intracellular Ca 2+ signals [74], including the circadian oscillation of Ca 2+ concentrations [75,76]. The changes in transcript abundance of CIPKs suggest their involvement in clock-related processes, similar to mammals in which Ca 2+ -regulated calmodulin kinase II (CaMKII) functions in clock regulation [77,78]. …”

Section: Resultsmentioning

confidence: 99%

Parallel analysis ofArabidopsiscircadian clock mutants reveals different scales of transcriptome and proteome regulation

et al. 2017

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The circadian clock regulates physiological processes central to growth and survival. To date, most plant circadian clock studies have relied on diurnal transcriptome changes to elucidate molecular connections between the circadian clock and observable phenotypes in wild-type plants. Here, we have integrated RNA-sequencing and protein mass spectrometry data to comparatively analyse the lhycca1, prr7prr9, gi and toc1 circadian clock mutant rosette at the end of day and end of night. Each mutant affects specific sets of genes and proteins, suggesting that the circadian clock regulation is modular. Furthermore, each circadian clock mutant maintains its own dynamically fluctuating transcriptome and proteome profile specific to subcellular compartments. Most of the measured protein levels do not correlate with changes in their corresponding transcripts. Transcripts and proteins that have coordinated changes in abundance are enriched for carbohydrate- and cold-responsive genes. Transcriptome changes in all four circadian clock mutants also affect genes encoding starch degradation enzymes, transcription factors and protein kinases. The comprehensive transcriptome and proteome datasets demonstrate that future system-driven research of the circadian clock requires multi-level experimental approaches. Our work also shows that further work is needed to elucidate the roles of post-translational modifications and protein degradation in the regulation of clock-related processes.

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Section: Resultsmentioning

confidence: 99%

Parallel analysis ofArabidopsiscircadian clock mutants reveals different scales of transcriptome and proteome regulation

et al. 2017

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“…; Kon et al . ). The tight relationship between CaMKII and energetic/synaptic homeostatic or circadian mechanisms raises the possibility that the CaMKII signaling pathway participates in sleep–wake regulation.…”

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confidence: 97%

Phosphorylation of CaMKII in the rat dorsal raphe nucleus plays an important role in sleep–wake regulation

Cui

et al. 2015

Journal of Neurochemistry

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“…Disturbed coupling within and among SCN neurons or SCN subpopulations (ventrolateral/dorsomedial SCN) might be an additional source for the DAO phenomenon and needs further investigation with particular emphasis on signal transduction and intercellular communication (Kon et al, 2014;Pauls et al, 2014;Wang et al, 2014;Welsh et al, 2010).…”

Section: Discussionmentioning

confidence: 99%

Light-induced c-Fos expression in the SCN and behavioural phase shifts of Djungarian hamsters with a delayed activity onset

Schöttner

Vuillez

Challet

et al. 2015

Chronobiology International

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C-Fos expression in the suprachiasmatic nucleus (SCN) and phase shifts of the activity rhythm following photic stimulation were investigated in Djungarian hamsters (Phodopus sungorus) of two different circadian phenotypes. Wild-type (WT) hamsters display robust daily patterns of locomotor activity according to the light/dark conditions. Hamsters of the DAO (delayed activity onset) phenotype, however, progressively delay the activity onset, whereas activity offset remains coupled to "light-on". Although the exact reason for the delayed activity onset is not yet clarified, it is connected with a disturbed interaction between the light/dark cycle and the circadian clock. The aim was to test the link between photoreception and the behavioral output of the circadian system in hamsters of both phenotypes, to get further insight in the underlying mechanism of the DAO phenomenon. Animals were exposed to short light pulses at different times during the dark period to analyze phase shifts of the activity rhythm and expression of Fos protein in the SCN. The results indicate that the photosensitive phase in DAO hamsters is shifted like the activity onset. Also, phase shifts were significantly smaller in DAO hamsters. At the same time, levels of Fos expression did not differ between phenotypes regarding the circadian phase. The results provide evidence that the shifted photosensitivity of the circadian system in DAO hamsters does not differ from that of WT animals, and lead us to conclude that processes within the SCN that enable light information to reset the circadian pacemaker might offer an explanation for the DAO phenomenon.

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CaMKII is essential for the cellular clock and coupling between morning and evening behavioral rhythms

Cited by 59 publications

References 48 publications

Parallel analysis ofArabidopsiscircadian clock mutants reveals different scales of transcriptome and proteome regulation

Parallel analysis ofArabidopsiscircadian clock mutants reveals different scales of transcriptome and proteome regulation

Phosphorylation of CaMKII in the rat dorsal raphe nucleus plays an important role in sleep–wake regulation

Light-induced c-Fos expression in the SCN and behavioural phase shifts of Djungarian hamsters with a delayed activity onset

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