Camellia sinensis fruit peel extract inhibits angiogenesis and ameliorates obesity induced by high-fat diet in rats

Prooxidant Effects of Epigallocatechin-3-Gallate in Health Benefits and Potential Adverse Effect

“…The activation of AMPK modulates the expression of genes and proteins involved in lipid metabolism, downregulates the expression of fat synthesis proteins, and upregulates lipid catabolism proteins [ 2 ]. It was shown that EGCG inhibited the expressions of glucose 6-phosphatase (G6Pase, for gluconeogenesis), phosphoenolpyruvate carboxykinase, (PEPCK, for gluconeogenesis), fatty acid synthase (FAS, for fatty acid synthesis), acetyl-CoA carboxylase (ACC, for fatty acid synthesis), hydroxymethylglutaryl-CoA reductase (HMGR, for cholesterol), sterol regulatory element-binding proteins (SREBPs, for sterol synthesis), peroxisome proliferator-activated receptor gamma (PPAR γ , for lipid synthesis and storage), and CCAAT/enhancer-binding protein alpha (C/EBP α , for adipogenesis) as well as enhanced the expression of acyl-CoA oxidase (ACO, for fatty acid oxidation), peroxisome proliferator-activated receptor alpha (PPAR α , for fatty acid oxidation), carnitine palmitoyltransferase-1 (CPT-1, for fatty acid oxidation), acyl-CoA dehydrogenase (ACAD, for fatty acid oxidation), peroxisome proliferator-activated receptor gamma coactivator-1 α (PGC-1 α , for fatty acid oxidation), uncoupling proteins (UCPs, for thermogenesis), and adipose triglyceride lipase (ATGL, for triglyceride hydrolysis) [ 50 – 54 ].…”

The Pharmacological Activity of Camellia sinensis (L.) Kuntze on Metabolic and Endocrine Disorders: A Systematic Review

“…Moreover, using experimental in vivo models, the effect of tea extracts and their bioactive compounds on changes in relevant biomarkers for obesity have been demonstrated. Green tea extract supplementation has anti-obesity effects by reducing body weight, white adipose tissue fat, liver fat accumulation, and serum triglyceride levels and by increasing lysophospholipids levels and energy expenditure [83][84][85][86][87][88][89][90][91]. These anti-obesity properties of green tea are mainly attributed to its polyphenols (i.e., epigallocatechin gallate and epigallocatechin) and polysaccharides [12,15].…”

Plants with potential use on obesity and its complications

“…A recent study showed that not only the leaf of C. sinensis has anti-obesity effect, but also the fruit peel, which is considered an agricultural waste (Chaudhary et al, 2014[ 28 ]). The administration of ethanolic green tea fruit peel extract (100 mg/kg/d) on high-fat diet feed female Sprague-Dawley rats for 50 days significantly decreased the body weight (approx.…”