Camelina Sativa Oil, but not Fatty Fish or Lean Fish, Improves Serum Lipid Profile in Subjects with Impaired Glucose Metabolism—A Randomized Controlled Trial

Schwab, Ursula; Lankinen, Maria; Mello, Vanessa D. de; Manninen, Suvi; Kurl, Sudhir; Pulkki, Kari; Laaksonen, David E.; Erkkilä, Arja T.

doi:10.1002/mnfr.201700503

Cited by 41 publications

(97 citation statements)

References 55 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The camelina oil consumption was 25.7 ± 2.7 g per day in the CSO group. Dietary intakes have been reported in detail elsewhere . The proportion of ALA (18:3n‐3) in plasma phospholipids increased in CSO group ( p < 0.001) and differed significantly from the other groups.…”

Section: Resultsmentioning

confidence: 80%

See 1 more Smart Citation

Intake of Fatty Fish Alters the Size and the Concentration of Lipid Components of HDL Particles and Camelina Sativa Oil Decreases IDL Particle Concentration in Subjects with Impaired Glucose Metabolism

Manninen

Lankinen

Mello

et al. 2018

Molecular Nutrition Food Res

Self Cite

View full text Add to dashboard Cite

show abstract

Section: Resultsmentioning

confidence: 80%

“…There were no differences in baseline characteristics among the study groups ( Table ). Reported physical activity of the subjects did not change during the study . The average number of fish meals per week was 4.4 ± 0.4 in the FF, 4.3 ± 0.5 in the LF, 0.9 ± 0.4 in the CSO, and 0.9 ± 0.4 in the control group during the study.…”

Section: Resultsmentioning

confidence: 89%

Intake of Fatty Fish Alters the Size and the Concentration of Lipid Components of HDL Particles and Camelina Sativa Oil Decreases IDL Particle Concentration in Subjects with Impaired Glucose Metabolism

Manninen

Lankinen

Mello

et al. 2018

Molecular Nutrition Food Res

Self Cite

View full text Add to dashboard Cite

show abstract

“…Recruitment and characteristics of the subjects have previously been described (Schwab et al, ). The main inclusion criterion was fasting plasma glucose concentration 5.6–7.0 mmoL/L.…”

Section: Methodsmentioning

confidence: 99%

“…The study diets were isocaloric and they were based on current nutrient recommendations (Becker et al, 2004;Perk et al, 2012) excluding fish and ALA intakes. Details of study diets have been reported (Schwab et al, 2018). The fatty fish group consumed four fish meals of fatty fish (e.g.…”

Section: Study Dietsmentioning

confidence: 99%

Camelina sativa Oil, Fatty Fish, and Lean Fish Do Not Markedly Affect Urinary Prostanoids in Subjects with Impaired Glucose Metabolism

Erkkilä

Lee

Lankinen

et al. 2019

Lipids

Self Cite

View full text Add to dashboard Cite

Dietary fatty acids are suggested to affect oxidative stress; however, results from interventions have been inconclusive. The aim was to examine if fatty fish, lean fish, and Camelina sativa oil (CSO) affect the urinary prostanoid levels in subjects with impaired glucose metabolism. Altogether 79 participants aged 43–72 years completed a randomized controlled study lasting 12 weeks. There were four parallel groups, fatty fish, lean fish (four fish meals/week in both), CSO providing 10 g/day alpha‐linolenic acid (ALA), and control diet with limited fish and ALA containing oil consumption. Urinary prostanoids (prostaglandin F2α, 5‐F2t‐isoprostanes and 15‐F2t‐isoprostane metabolites, isofuran, 8‐F3t‐isoprostanes, and 4‐(RS)‐4‐F4t‐neuroprostane) of 72 participants (age: mean (±SD) 58.9 ± 6.5 years; body mass index: 29.3 ± 2.5 kg/m2) collected over 12‐h were measured using liquid chromatography tandem‐mass spectrometry. Plasma phospholipid fatty acids were determined using gas chromatography. Our study showed that the proportion of ALA in plasma phospholipids increased in the CSO group (overall difference among the groups p‐value <0.001). In the fatty fish group, proportions of eicosapentaenoic and docosahexaenoic acids increased (overall p‐value <0.001 for both). Prostaglandin F2α was higher in the CSO group than in the control group (p < 0.05), however, there were no other significant changes in urinary excretion of other prostanoids among the study groups. At baseline, arachidonic acid in plasma phospholipids was positively (r = 0.247, p < 0.05) and ALA negatively (r = −0.326, p < 0.05) associated with urinary total isoprostanes. In conclusion, CSO, fatty fish, and lean fish consumption do not cause major changes in oxidative stress markers in subjects with impaired glucose tolerance.

show abstract

“…The strengths of the current study include a randomized controlled study design and good 338 compliance with study diets, as previously reported [25]. However, there are also some 339 limitations to consider.…”

mentioning

confidence: 92%

The effect of intakes of fish and Camelina sativa oil on atherogenic and anti-atherogenic functions of LDL and HDL particles: A randomized controlled trial

et al. 2019

Self Cite

View full text Add to dashboard Cite

Please cite this article as: Manninen S, Lankinen M, Erkkilä A, Nguyen SD, Ruuth M, de Mello V, Öörni K, Schwab U, The effect of intakes of fish and Camelina sativa oil on atherogenic and antiatherogenic functions of LDL and HDL particles: A randomized controlled trial, Atherosclerosis, https:// Abstract 1 M A N U S C R I P T A C C E P T E D ACCEPTED MANUSCRIPT 2 Background and aims: Omega-3 fatty acids are known to have several cardioprotective 2 effects. Our aim was to investigate the effects of intakes of fish and Camelina sativa oil 3 (CSO), rich in alpha-linolenic acid, on the atherogenic and anti-atherogenic functions of LDL 4 and HDL particles.5Methods: Altogether, 88 volunteers with impaired glucose metabolism were randomly 6 assigned to CSO (10 g of alpha-linolenic acid/day), fatty fish (4 fish meals/week), lean fish (4 7 fish meals/week) or control group for 12 weeks. 79 subjects completed the study. The binding 8 of lipoproteins to aortic proteoglycans, LDL aggregation and activation of endothelial cells 9 by LDL and cholesterol efflux capacity of HDL were determined in vitro. 10 Results: Intake of CSO decreased the binding of lipoproteins to aortic proteoglycans in a non-11 normalized model (p=0.006). After normalizing with serum concentrations of non-HDL 12 cholesterol, apolipoprotein B (apoB) or LDL cholesterol, which decreased in the CSO group, 13 the change was no longer statistically significant. In the fish groups, there were no changes in 14 the binding of lipoproteins to proteoglycans. Regarding other lipoprotein functions, there 15 were no changes in any of the groups. 16 Conclusions: Intake of CSO decreases the binding of lipoproteins to aortic proteoglycans by 17 decreasing serum LDL cholesterol concentration, which suggests that the level of apoB-18 containing lipoproteins in the circulation is the main driver of lipoprotein retention within the 19 arterial wall. Intake of fish or CSO has no effects on other lipoprotein functions. 20 21 Keywords: cholesterol efflux, diet, human, interleukin-8, LDL aggregation, omega-3 fatty 22 acid, proteoglycan 23 24 42 43 Cholesterol efflux from macrophage foam cells has a central role in the reverse cholesterol 44 transport, which is considered the primary anti-atherogenic mechanism of HDL [12]. HDL 45 particles, however, possess also several other atheroprotective activities, such as anti-46 inflammatory and antioxidative functions [12, 13]. The profile and structure of HDL particles 47 157 Culture of primary human monocyte-derived macrophages 158 Human monocytes were isolated from buffy coats (Finnish Red Cross Blood Transfusion 159 Center, Helsinki, Finland) by centrifugation in Ficoll-Paque gradient as described [31]. 160 Washed cells were suspended in DMEM supplemented with 100 U/ml penicillin and 100 161 µg/ml streptomycin, counted, and seeded on 24 well-plates (1.5 million cells per well). After 162 1 h incubation, non-adherent cells were removed, and the medium was replaced with 163 macrophage-SFM medium (Gibco) supplemented with 1% penicillin-s...

show abstract

Camelina Sativa Oil, but not Fatty Fish or Lean Fish, Improves Serum Lipid Profile in Subjects with Impaired Glucose Metabolism—A Randomized Controlled Trial

Abstract: A diet enriched in CSO improves serum lipid profile as compared with a diet enriched in FF or LF in subjects with impaired fasting glucose, with no differences in glucose metabolism or concentrations of inflammatory markers.

Cited by 41 publications

References 55 publications

Intake of Fatty Fish Alters the Size and the Concentration of Lipid Components of HDL Particles and Camelina Sativa Oil Decreases IDL Particle Concentration in Subjects with Impaired Glucose Metabolism

Intake of Fatty Fish Alters the Size and the Concentration of Lipid Components of HDL Particles and Camelina Sativa Oil Decreases IDL Particle Concentration in Subjects with Impaired Glucose Metabolism

Camelina sativa Oil, Fatty Fish, and Lean Fish Do Not Markedly Affect Urinary Prostanoids in Subjects with Impaired Glucose Metabolism

The effect of intakes of fish and Camelina sativa oil on atherogenic and anti-atherogenic functions of LDL and HDL particles: A randomized controlled trial

Contact Info

Product

Resources

About