Camel milk as an alternative treatment regimen for diabetes therapy

Hussain, Humaira; Wattoo, Feroza Hamid; Wattoo, Muhammad Hamid Sarwar; Gülfraz, Muhammad; Masud, Tariq; Shah, Imam; Ali, Sakhawat; Alavi, Seyed Ebrahim

doi:10.1002/fsn3.2078

Cited by 26 publications

(18 citation statements)

References 45 publications

(55 reference statements)

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“…The significant decrease of blood glucose level in these study are in agreement with that found by Hussain et al [65], who observed that the mean blood glucose in diabetic mice decreased from 346 (mg/dl) to 140 (mg/dl) after treated with camel milk (83ml/ kg body weight for 7 weeks) which is not significantly different from the diabetic mice receiving glibenclamide (antidiabetic druge) in a dose of 600 µg/kg body weight (blood glucose of 125 mg/dl). Also, Shori and Baba [66], reported that the fermented plain camel milk had higher anti-diabetic activity than fermented plain cow milk.…”

Section: Discussionsupporting

confidence: 93%

“…So, the observed renal protective effects of camel milk treatment, in diabetic rats, could be assigned to the glucose homeostatic action of camel milk. This was in accord with the earlier findings by Agrawal et al, [70] of a significant reduction of the microalbuminuria in type 1 diabetes mellitus patients receiving camel milk along with their standard antidiabetic therapy suggesting a direct protective effect of camel milk against diabetic nephropathy [65,94,95].…”

Section: Discussionsupporting

confidence: 93%

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The biological effects of fermented camel milk fortified with sage (Salvia officinalis L.) and mint (Mentha piperita) leaves powder on alloxan-induced diabetic rats

Shahein

Elmeligy

El-Sayed

2022

Preprint

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Background: Diabetes mellitus (DM) is a chronic metabolic condition described by persistent hyperglycemia due to low secretion of insulin, insulin resistance, or a combination of both. Many studies suggested the potential anti-diabetic effect of camel milk and the important role of the bioactive components of mint and sage in decreasing the side effects of diabetes disease. This study was designed to assess the anti-diabetic potential of fermented camel milk fortified with sage or mint leaves powder (1 and 1.5%) in alloxan-induced diabetic rats. Methods: Forty-two adult normal male albino rats were taken for the study where one group was kept as the non-diabetic control group (6 rats) while others 36 rats were made diabetic by alloxan injection (150 mg/kg of body weight). Among diabetic rats, a control (+) group (6 rats) was kept and referred to as diabetic control whereas the other 5 groups (7rats each) of diabetic rats were fed on fermented camel milk (FCM) or fermented camel milk fortified with sage or mint leaves powder( 1 and 1.5%). Results: The oral administration of fermented camel milk fortified with sage or mint leaves powder caused a significant decreased in blood glucose level and lipid profile, and increased in insulin level compared to the control (+) and FCM groups, and the best results were observed with fermented camel milk fortified with 1.5% sage powder. The results also found that the fermented camel milk fortified with sage or mint leaves powder improved the liver and kidney functions of diabetic rats. Importantly, treatment of diabetic animals fermented camel milk fortified with sage or mint leaves powder resulted in significant amelioration of the histopathological changes of pancreatic, liver, and kidney observed in diabetic animals. Conclusion: Our study recommends the use of sage and mint leaves powder (at a ratio of 1.5%) with fermented camel milk to produce functional food products with anti-diabetic activity.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 93%

The biological effects of fermented camel milk fortified with sage (Salvia officinalis L.) and mint (Mentha piperita) leaves powder on alloxan-induced diabetic rats

Shahein

Elmeligy

El-Sayed

2022

Preprint

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“…Most recently, the antidiabetic effect of CM in a diabetes mouse model, by simultaneous measurement of blood glycemia, showed that blood glucose and HbA1c were significantly reduced compared to that in the diabetic control group. Interestingly, researchers found that the therapeutic effect of CM was completely comparable with the glibenclamide antidiabetic drug, suggesting that CM could be used as an alternative regimen in the medical nutrition therapy of diabetes [ 55 ].…”

Section: Discussionmentioning

confidence: 99%

Effect of Camel Milk on Glucose Homeostasis in Patients with Diabetes: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

et al. 2022

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The effects of camel milk (CM) intake on glycemic control in patients with diabetes are controversial. This systematic review and meta-analysis of randomized controlled trials (RCTs) was conducted to summarize the effect of CM intake on glucose homeostasis parameters in patients with both types of diabetes mellitus; T1DM and T2DM. We searched Google Scholar, PubMed/MEDLINE, EBSCO host, CINAHL, ScienceDirect, Cochrane, ProQuest Medical, Web of Science, and Scopus databases from inception until the end of November 2021. Relevant RCTs were identified, and the effect size was reported as mean difference (MD) and standard deviation (SD). Parameters of glycosylated hemoglobin (HbA1c), fasting blood glucose (FBG), postprandial blood glucose (PBG), fasting serum insulin (FI), insulin resistance (expressed in terms of HOMA-IR), insulin dose (ID) received, serum insulin antibody (IA), and C-peptide (CP) were tested. Out of 4054 collected articles, 14 RCTs (total 663 subjects) were eligible for inclusion. The pooled results obtained using a random-effects model showed a statistically significant decrease in HbA1c levels (MD, −1.24, 95% confidence interval (CI): −2.00, −0.48, p < 0.001 heterogeneity (I2) = 94%) and ID received (MD, −16.72, 95% CI: −22.09, −11.35 p < 0.00001, I2 = 90%), with a clear tendency was shown, but non-significant, to decrease FBG (MD, −23.32, 95% CI: −47.33, 0.70, p = 0.06, I2 = 98%) in patients with diabetes who consumed CM in comparison to those on usual care. Conversely, the consumption of CM did not show significant reductions in the rest of the glucose homeostasis parameters. Subgroup analysis revealed that patients with T2DM were more beneficially affected by CM intake than those with T1DM in lowering FBG, while patients with T1DM were more beneficially affected by CM intake than those with T2DM in lowering HbA1c. Both fresh and treated (pasteurized/fermented) CM gave similar beneficial effects in lowering HbA1c. Lastly, a relatively superior effect for longer duration on shorter duration (>6 months, ≤6 months, respectively) of CM intake is found in lowering HbA1c. To conclude, long-term consumption of CM by patients with diabetes could be a useful adjuvant therapy alongside classical medications, especially in lowering the required insulin dose and HbA1c. Due to the high heterogeneity observed in the included studies, more controlled trials with a larger sample size are warranted to confirm our results and to control some confounders and interfering factors existing in the analyzed articles.

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“…In addition, there is presented another study regarding diabetes and camel milk on animal model, which aimed to evaluate the antidiabetic and hepatoprotective effects, as well as lipid profile restoration of camel milk in the diabetic mouse model with duration of 7 week. As a result, scientists suggested that the camel milk could be used as a proper alternative treatment regimen for diabetes therapy [ 14 ]. Different work was investigated as a review about camel milks nutritional, antimicrobial and medicinal properties.…”

Section: Introductionmentioning

confidence: 99%

The effect of camel milk curd masses on rats blood serum biochemical parameters: Preliminary study

et al. 2021

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This study aimed to assess potential feeding effect of camel milk curd mass and its mixes to experimental rat’s blood serum biochemical parameters, enzymatic activity and the peptide toxicity. Fifty healthy male Sprague-Dawley rats were divided into five groups (n = 10 each). Each group was fed with camel milk pure curd mass and its mixes for 16 days. At the end of the experiment, rats were sacrificed to collect the samples from the blood serum. Blood serum biochemical parameters total protein, cholesterol, glucose, albumin, triglycerides; the enzymatic activities of alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase were determined on the A25 automatic analyser, and peptide toxicity analysed by the reference method. The statistical data have shown no significant differences in body weight gain in all groups. Total protein decreased in group II, IV, and V; however, it increased in group III compared to the control group. Cholesterol grew up in group II and it slightly increased in group V, dropped in groups III and IV compared to group I result. Glucose increased in groups II, III, IV compared to group I; still, group V results show a slight decrease. Albumin decreased in group IV, yet in group V it increased than the group I result. Simultaneously, groups II and III results were changed with less percentage. Triglyceride grew up in groups II, V, and it dropped significantly in groups III, IV compared to the control group. De Ritis ratio of enzymes in groups II, III, and IV fluctuated between 1.31 and 0.98 IU/L; however, group V demonstrated significant data versus group I. Diets peptide toxicity in all groups was lower than control group data. The experimental results indicated that curd mass from camel milk could be used as a pure or with additives and it did not discover the observed side effects.

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Camel milk as an alternative treatment regimen for diabetes therapy

Cited by 26 publications

References 45 publications

The biological effects of fermented camel milk fortified with sage (Salvia officinalis L.) and mint (Mentha piperita) leaves powder on alloxan-induced diabetic rats

The biological effects of fermented camel milk fortified with sage (Salvia officinalis L.) and mint (Mentha piperita) leaves powder on alloxan-induced diabetic rats

Effect of Camel Milk on Glucose Homeostasis in Patients with Diabetes: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

The effect of camel milk curd masses on rats blood serum biochemical parameters: Preliminary study

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