Calycosin suppresses expression of pro-inflammatory cytokines via the activation of p62/Nrf2-linked heme oxygenase 1 in rheumatoid arthritis synovial fibroblasts

Su, Xiaohui; Huang, Qingchun; Chen, Jianyu; Wang, Maojie; Pan, Hudan; Wang, Rui; Zhou, Hua; Zhou, Zhanqing; Liu, Juan; Yang, Fen; Li, Ting; Liu, Liang

doi:10.1016/j.phrs.2016.09.031

Cited by 78 publications

(45 citation statements)

References 40 publications

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“…Calycosin, an isoflavone phytoestrogen isolated from Astragalus membranaceus , is reported to have various therapeutic uses, such as anticancer, antivirus, antioxidation, and anti‐inflammation effects (Chen, Lin, Yong, Ye, & Huang, ; X. Wang & Zhao, ; Zhao, Li, Ren, Tian, & Chen, ; Zhu et al, ). Previous studies also indicated that calycosin exerted a neuroprotective effect on cerebral ischemia (Y. Wang, Ren, Zhang, Lu, & Chen, ), mitigated Alzheimer's disease symptoms by improving cognitive function in mice model (Song, Li, Bai, Gao, & Wang, ), and the pro‐inflammatory cytokines levels in rheumatoid arthritis synovial fibroblasts (Su et al, ). Notably, calycosin was reported to effectively decrease the phosphorylation of mitogen‐activated protein kinases (MAPKs) induced by ovariectomy and protects against acute pancreatitis by exerting anti‐inflammatory and antioxidative stress effects via the P38 MAPK and nuclear factor kappa B (NF‐κB) signal pathways, which immediately prompted us to investigate the potential therapeutic value of this compound in vivo and in vitro (N. Li et al, ; Ma et al, ).…”

Section: Introductionmentioning

confidence: 92%

Calycosin attenuates MPTP‐induced Parkinson's disease by suppressing the activation of TLR/NF‐κB and MAPK pathways

Yang

Jia

Zhang

et al. 2018

Phytotherapy Research

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Parkinson is the second common neurodegenerative disease. The characteristics of Parkinson's disease (PD) are the dopamin neurons loss caused by neuroinflammation responses. C alycosin, an isoflavone phytoestrogen isolated from Astragalus membranaceus, has multiple pharmacological activities, such as anti-inflammation, anti-tumor, and neuroprotective effects. However, it is unknown whether calycosin can mitigate PD symptoms. This study aims to explore whether calycosin can alleviate PD symptoms and the underlying mechanisms. PD was induced in mice by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) injection, and calycosin was given intracerebroventricularly to these mice. A cell model of nerve inflammation was established by BV2 microglia cells injected with lipopolysaccharide (LPS). The motor states were evaluated by stepping, whisker, and cylinder experiments. The states of dopaminergic neurons and microglia were detected by immunostainning of tyrosine hydroxylase and cluster of differentiation molecule 11b (CD11b). The expression levels of inflammatory factors were detected by qPCR. Toll-like receptor (TLR)/ nuclear factor kappa B (NF-κB) and mitogen-activated protein kinase (MAPK) pathways were investigated by western blot. We found that calycosin treatment mitigated the behavioral dysfunctions and inflammatory responses in MPTP-induced PD mice. The TLR/NF-κB and MAPK pathways in MPTP-induced PD mice were inhibited by calycosin treatment, which was coincident with experiments in LPS-induced BV2 cells. Above all, calycosin mitigates PD symptoms through TLR/NF-κB and MAPK pathways in mice and cell lines.KEYWORDS

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Section: Introductionmentioning

confidence: 92%

Calycosin attenuates MPTP‐induced Parkinson's disease by suppressing the activation of TLR/NF‐κB and MAPK pathways

Yang

Jia

Zhang

et al. 2018

Phytotherapy Research

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“…Curcumin stimulates HO‐1 gene activity by promoting inactivation of the NRF2–KEAP1 complex, leading to increased NRF2 binding to the resident HO‐1 AREs . Calycosin, a compound derived from the Chinese medicinal herb Radix Astragali , has similar effects, as it activates HO‐1 and NRF2 in synovial fibroblasts from arthritic patients and inhibits proinflammatory factors . The widely applied antioxidant AA was able to reduce apoptosis and loss of viability and markedly decreased H 2 O 2 ‐mediated senescence of chondrocytes.…”

Section: Effects Of Plant‐derived or Synthetic Antioxidants On Nrf2 Ementioning

confidence: 99%

Oxidative stress and chronic inflammation in osteoarthritis: can NRF2 counteract these partners in crime?

Marchev

Dimitrova

Burns

et al. 2017

Annals of the New York Academy of Sciences

174

135

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“…In line with this notion, pharmacological activation of NRF2 had been shown to suppress IL-6 expression in several cell types. Pirfenidone and calycosin activate NRF2 signaling via different mechanisms and reduce IL-6 secretion in fibroblasts [ 186 , 187 ]. Red ginseng-derived saponin fraction decreases IL-6 production in macrophages and adipocytes in an NRF2 dependent manner [ 188 ].…”

Section: Potential Roles Of Nrf2 In Cells In the Marrow Microenvirmentioning

confidence: 99%

NRF2 Is One of the Players Involved in Bone Marrow Mediated Drug Resistance in Multiple Myeloma

Yen

Hsiao

2018

IJMS

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Multiple myeloma with clonal plasma expansion in bone marrow is the second most common hematologic malignancy in the world. Though the improvement of outcomes from the achievement of novel agents in recent decades, the disease progresses and leads to death eventually due to the elusive nature of myeloma cells and resistance mechanisms to therapeutic agents. In addition to the molecular and genetic basis of resistance pathomechanisms, the bone marrow microenvironment also contributes to disease progression and confers drug resistance in myeloma cells. In this review, we focus on the current state of the literature in terms of critical bone marrow microenvironment components, including soluble factors, cell adhesion mechanisms, and other cellular components. Transcriptional factor nuclear factor erythroid-derived-2-like 2 (NRF2), a central regulator for anti-oxidative stresses and detoxification, is implicated in chemoresistance in several cancers. The functional roles of NRF2 in myeloid-derived suppressor cells and multiple myeloma cells, and the potential of targeting NRF2 for overcoming microenvironment-mediated drug resistance in multiple myeloma are also discussed.

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Calycosin suppresses expression of pro-inflammatory cytokines via the activation of p62/Nrf2-linked heme oxygenase 1 in rheumatoid arthritis synovial fibroblasts

Cited by 78 publications

References 40 publications

Calycosin attenuates MPTP‐induced Parkinson's disease by suppressing the activation of TLR/NF‐κB and MAPK pathways

Calycosin attenuates MPTP‐induced Parkinson's disease by suppressing the activation of TLR/NF‐κB and MAPK pathways

Oxidative stress and chronic inflammation in osteoarthritis: can NRF2 counteract these partners in crime?

NRF2 Is One of the Players Involved in Bone Marrow Mediated Drug Resistance in Multiple Myeloma

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