Calycosin ameliorates diabetes-induced cognitive impairments in rats by reducing oxidative stress via the PI3K/Akt/GSK-3β signaling pathway

Wang, Xiang; Zhao, Linhui

doi:10.1016/j.bbrc.2016.03.024

Cited by 88 publications

(53 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Several epidemiological data found an association between diabetes and lower cognitive test performance [182]. Experimental findings have shown significant cognitive impairment in STZ-induced diabetic rats [183]. CAV1 expression is impaired during prolonged HGC in cell lines and brain neurons of diabetic rats [184][185][186].…”

Section: Role Of Caveolin-1 In Oxidative Stressmentioning

confidence: 98%

Role of Caveolin-1 in Diabetes and Its Complications

Haddad

Madhoun

Nizam

et al. 2020

Oxidative Medicine and Cellular Longevity

View full text Add to dashboard Cite

It is estimated that in 2017 there were 451 million people with diabetes worldwide. These figures are expected to increase to 693 million by 2045; thus, innovative preventative programs and treatments are a necessity to fight this escalating pandemic disorder. Caveolin-1 (CAV1), an integral membrane protein, is the principal component of caveolae in membranes and is involved in multiple cellular functions such as endocytosis, cholesterol homeostasis, signal transduction, and mechanoprotection. Previous studies demonstrated that CAV1 is critical for insulin receptor-mediated signaling, insulin secretion, and potentially the development of insulin resistance. Here, we summarize the recent progress on the role of CAV1 in diabetes and diabetic complications.

show abstract

Section: Role Of Caveolin-1 In Oxidative Stressmentioning

confidence: 98%

Role of Caveolin-1 in Diabetes and Its Complications

Haddad

Madhoun

Nizam

et al. 2020

Oxidative Medicine and Cellular Longevity

View full text Add to dashboard Cite

show abstract

“…Calycosin, an isoflavone phytoestrogen isolated from Astragalus membranaceus , is reported to have various therapeutic uses, such as anticancer, antivirus, antioxidation, and anti‐inflammation effects (Chen, Lin, Yong, Ye, & Huang, ; X. Wang & Zhao, ; Zhao, Li, Ren, Tian, & Chen, ; Zhu et al, ). Previous studies also indicated that calycosin exerted a neuroprotective effect on cerebral ischemia (Y. Wang, Ren, Zhang, Lu, & Chen, ), mitigated Alzheimer's disease symptoms by improving cognitive function in mice model (Song, Li, Bai, Gao, & Wang, ), and the pro‐inflammatory cytokines levels in rheumatoid arthritis synovial fibroblasts (Su et al, ).…”

Section: Introductionmentioning

confidence: 99%

Calycosin attenuates MPTP‐induced Parkinson's disease by suppressing the activation of TLR/NF‐κB and MAPK pathways

Yang

Jia

Zhang

et al. 2018

Phytotherapy Research

View full text Add to dashboard Cite

Parkinson is the second common neurodegenerative disease. The characteristics of Parkinson's disease (PD) are the dopamin neurons loss caused by neuroinflammation responses. C alycosin, an isoflavone phytoestrogen isolated from Astragalus membranaceus, has multiple pharmacological activities, such as anti-inflammation, anti-tumor, and neuroprotective effects. However, it is unknown whether calycosin can mitigate PD symptoms. This study aims to explore whether calycosin can alleviate PD symptoms and the underlying mechanisms. PD was induced in mice by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) injection, and calycosin was given intracerebroventricularly to these mice. A cell model of nerve inflammation was established by BV2 microglia cells injected with lipopolysaccharide (LPS). The motor states were evaluated by stepping, whisker, and cylinder experiments. The states of dopaminergic neurons and microglia were detected by immunostainning of tyrosine hydroxylase and cluster of differentiation molecule 11b (CD11b). The expression levels of inflammatory factors were detected by qPCR. Toll-like receptor (TLR)/ nuclear factor kappa B (NF-κB) and mitogen-activated protein kinase (MAPK) pathways were investigated by western blot. We found that calycosin treatment mitigated the behavioral dysfunctions and inflammatory responses in MPTP-induced PD mice. The TLR/NF-κB and MAPK pathways in MPTP-induced PD mice were inhibited by calycosin treatment, which was coincident with experiments in LPS-induced BV2 cells. Above all, calycosin mitigates PD symptoms through TLR/NF-κB and MAPK pathways in mice and cell lines.KEYWORDS

show abstract

“…Calycosin also was demonstrated to ameliorate diabetes-induced cognitive impairments via PI3K/Akt/GSK-3β signaling pathway 21 . Besides, calycosin acts as a Ca 2+ channel blocker, which may block voltage-dependent Ca 2+ channel and receptor-operated Ca 2+ channel 22 .…”

Section: Introductionmentioning

confidence: 99%

The Role of TRPC6 in the Neuroprotection of Calycosin Against Cerebral Ischemic Injury

Guo

et al. 2017

Sci Rep

View full text Add to dashboard Cite

Our previous studies have provided evidences that calycosin can protect the brain from ischemia/reperfusion injury, but its mechanisms is not fully understand. Transient receptor potential canonical 6 (TRPC6) has a critical role in promoting neuronal survival against cerebral ischemic injury. The aim of the present study is to test whether calycosin protects against cerebral ischemic injury through TRPC6-CREB pathway. In vivo, rats were subjected to transient middle cerebral artery occlusion (MCAO) for 2 h and then treated with different doses of calycosin at the onset of reperfusion. In vitro, primary cultured neurons were treated by calycosin, then exposed to 2 h oxygen glucose deprivation (OGD) followed by 24 h reoxygenation. Our results showed that treatment with calycosin protected against ischemia-induced damages by increasing TRPC6 and P-CREB expression and inhibiting calpain activation. The neuroprotection effect of calycosin was diminished by inhibition or knockdown of TRPC6 and CREB. These findings indicated that the potential neuroprotection mechanism of calycosin was involved with TRPC6-CREB pathway.

show abstract

Calycosin ameliorates diabetes-induced cognitive impairments in rats by reducing oxidative stress via the PI3K/Akt/GSK-3β signaling pathway

Cited by 88 publications

References 29 publications

Role of Caveolin-1 in Diabetes and Its Complications

Role of Caveolin-1 in Diabetes and Its Complications

Calycosin attenuates MPTP‐induced Parkinson's disease by suppressing the activation of TLR/NF‐κB and MAPK pathways

The Role of TRPC6 in the Neuroprotection of Calycosin Against Cerebral Ischemic Injury

Contact Info

Product

Resources

About