Calycophyllum spruceanum BENTH ameliorates acute inflammation in mice

Silva, Ana Paula Azevedo Barros da; Amorim, Renata Morais Ferreira; Lopes, Roberta de Freitas; Mota, Mário Rogério Lima; Silva, Felipe M. A. da; Koolen, Héctor H. F.; Lima, Émerson Silva; Assreuy, Ana Maria Sampaio; Cunha, Renildo Moura da

doi:10.1016/j.jep.2018.03.023

Cited by 4 publications

(7 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…23 OS-01 is a unique senotherapeutic peptide, shown to be safe 24 hydrating, antioxidant, anti-inflammatory and regenerative effects on skin. [25][26][27][28][29][30][31] Nevertheless, the clinical results observed in the present study highlight the benefits brought by the inclusion of the senotherapeutic OS-01 peptide in the tested topical formulation.…”

Section: Discussionmentioning

confidence: 50%

Double‐blind, vehicle‐controlled clinical investigation of peptide OS‐01 for skin rejuvenation

Zonari,

Brace,

Harder

et al. 2024

J of Cosmetic Dermatology

View full text Add to dashboard Cite

IntroductionSenescent cells contribute to age‐related tissue deterioration, including the skin, which plays important roles in overall health and social interactions. This study aimed to assess the effects of the senotherapeutic peptide, OS‐01 (a.k.a. Pep 14), on skin.MethodsA 12‐week split‐face, double‐blinded, vehicle‐controlled study involving 22 participants was conducted. The OS‐01‐containing formulation was applied to one side of the face, while the other side received an identical control formulation lacking the peptide. Skin characteristics were assessed using instrumental measurements, expert clinical grading, and subjective questionnaires.ResultsResults showed that the OS‐01 formulation significantly improved one aspect of skin barrier function, as evidenced by reduced trans‐epidermal water loss compared to both baseline and vehicle control. Expert grading and Antera 3D image analysis revealed a reduction in wrinkle appearance and indentation in the periorbital area, and improved skin texture and radiance on both sides of the face, with the OS‐01‐containing formulation demonstrating superior results. Participants also perceived improvements in skin hydration, smoothness, radiance, and overall appearance.ConclusionThe findings suggest that the OS‐01 formulation promotes skin health by strengthening the skin barrier, protecting against dehydration, reducing the appearance of wrinkles, and improving skin texture and radiance. These effects are likely attributed to the senotherapeutic properties of OS‐01 in reducing cellular senescence and its associated detrimental effects.

show abstract

Section: Discussionmentioning

confidence: 50%

Double‐blind, vehicle‐controlled clinical investigation of peptide OS‐01 for skin rejuvenation

Zonari,

Brace,

Harder

et al. 2024

J of Cosmetic Dermatology

View full text Add to dashboard Cite

show abstract

“…Also, other studies have shown that mitogen-activated protein kinase (MAPKs) contribute to the activation of NF-κB, in the TPA-induced skin inflammation in mice ( 33 ). As previously mentioned, plant extract has been effective in the acute model of inflammation by TPA ( 26 ). The present data, also indicated that the extract significantly inhibits the subacute inflammation resulted in the repeated application of TPA.…”

Section: Discussionmentioning

confidence: 95%

“…In the first phase (0 to 1 h after the sub-plantar injection of carrageenan) inflammatory agents such as histamine, serotonin, and bradykinin, and to some extent, also prostaglandins have crucial roles. While the second phase of inflammation, occurring 1 h after the injection of carrageenan, induces leukocyte infiltration, the production of free radicals derived from reactive oxygen species, the release of prostaglandins and proteases ( 26 ). Our previous study showed that the HESP inhibited inflammation induced by carrageenan in both phases ( 14 ).…”

Section: Discussionmentioning

confidence: 99%

“…Besides, the topical anti-inflammatory effects of the extract propose the presence of at least one lipophilic compound that crosses the skin barrier that exhibits topical antiphlogistic effects ( 34 ). Histological studies of TPA-treated ears revealed that the extract is an effective inhibitor of neutrophilic migration and pathological changes ( 26 ).…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Effect of ethanolic extract of Stachys pilifera Benth on subacute experimental models of inflammation and some underlying mechanisms

Zarezade¹,

Sadeghi

Kokhdan

et al. 2021

Res Pharma Sci

View full text Add to dashboard Cite

Background and purpose: This study was designed to evaluate the anti-inflammatory activities of S. pilifera (HESP) in two sub-acute models of inflammation and clarified some possible mechanisms. Experimental approach: Colorimetric methods were used to determine total phenol and flavonoid contents. Carrageenan or formalin-induced rat paw edema (seven days) and multiple application TPA-induced ear edema in mice (9 days) were used. The concentration of IL-1 and TNF-α were measured in the inflamed paw, as well as MDA levels in the serum and liver. Histopathological studies and in vitro anti-inflammatory effects of the extract were also studied using heat-or hypotonicity-induced hemolysis in RBC humans. Findings/Results: Total phenol and flavonoid contents of HESP were 101.35 ± 2.96 mg GAE/g extract and 660.79 ± 10.06 mg RE g extract, respectively. Oral (100 and 200 mg/kg) and topical application (5 mg/ear) of HESP significantly inhibited formalin-induced paw edema and multiple TPA-induced ear edema. The extract also significantly decreased the serum and liver levels of MDA in the carrageenan and formalin tests. The elevated levels of TNF-α and IL-1β in the carrageenan-injected paw were not affected by HESP. The extract (50-800 μg/mL) inhibited heat-or hypotonicity-induced hemolysis. Histopathological examination of the inflamed tissues revealed that HESP inhibited congestion and leukocyte infiltration. Conclusion and implications: The findings confirmed the potent anti-inflammatory effects of S. pilifera in two sub-acute inflammation models and suggested that these properties were not related to IL-1 and TNF-α, but could be attributed to inhibition of lipid peroxidation, membrane stabilization, and inhibition of leukocyte penetration.

show abstract

“…The extract of mulateiro bark (Calycophyllum spruceanum), known as the "tree of youth," has drawn the attention of the cosmetics industry owing to its antiaging, antimicrobial, and anti-inflammatory properties. [37,38] To assess coating formation, particle surface morphology was analyzed using environmental scanning electron microscopy (ESEM) and atomic force microscopy (AFM). Chemical changes were characterized using Fourier transform infrared (FTIR) and Raman spectroscopies.…”

mentioning

confidence: 99%

Plasma‐induced formation of coatings on vegetable ivory microparticles immersed in silicone oil: Enhancing surface coverage using natural products

Ferreira da Silva,

Almeida,

Veiga

et al. 2023

Plasma Processes & Polymers

View full text Add to dashboard Cite

Aiming to enhance the potential applications of bioproducts, we developed an innovative approach for their hydrophobization using plasma activation of liquids. In this study, microparticles of vegetable ivory, a porous hygroscopic material, were treated by an air plasma jet while immersed in silicone oil. The in‐liquid plasma treatment formed coatings that reduced particle water vapor sorption. Pore surface coverage and sorption reduction were enhanced by mixing silicone oil with copaiba oil‐resin (Copaifera spp.). Mulateiro extract (Calycophyllum spruceanum) was not as effective, owing to a lower affinity with silicone oil. For the first time, we demonstrate the plasma‐induced coating formation on particles immersed in liquid mixtures, a process in which liquid–liquid interfacial properties play a fundamental role.

show abstract

Calycophyllum spruceanum BENTH ameliorates acute inflammation in mice

Cited by 4 publications

References 26 publications

Double‐blind, vehicle‐controlled clinical investigation of peptide OS‐01 for skin rejuvenation

Double‐blind, vehicle‐controlled clinical investigation of peptide OS‐01 for skin rejuvenation

Effect of ethanolic extract of Stachys pilifera Benth on subacute experimental models of inflammation and some underlying mechanisms

Plasma‐induced formation of coatings on vegetable ivory microparticles immersed in silicone oil: Enhancing surface coverage using natural products

Contact Info

Product

Resources

About