Caltech Conte Center, a multimodal data resource for exploring social cognition and decision-making

Abstract

This data release of 117 healthy community-dwelling adults provides multimodal high-quality neuroimaging and behavioral data for the investigation of brain-behavior relationships. We provide structural MRI, resting-state functional MRI, movie functional MRI, together with questionnaire-based and task-based psychological variables; many of the participants have multiple datasets from retesting over the course of several years. Our dataset is distinguished by utilizing open-source data formats and processing tools (BIDS, FreeSurfer, fMRIPrep, MRIQC), providing data that is thoroughly quality checked, preprocessed to various extents and available in multiple anatomical spaces. A customizable denoising pipeline is provided as open-source code that includes tools for the generation of functional connectivity matrices and initialization of individual difference analyses. Behavioral data include a comprehensive set of psychological assessments on gold-standard instruments encompassing cognitive function, mood and personality, together with exploratory factor analyses. The dataset provides an in-depth, multimodal resource for investigating associations between individual differences, brain structure and function, with a focus on the domains of social cognition and decision-making.

Functional recruitment and connectivity of the cerebellum supports the emergence of Theory of Mind in early childhood

“…We leveraged openly accessible adult and developmental data from two previous studies which investigated social cognition in adults and typically developing children 33,28 . The Richardson et al 28 dataset includes data of 122 children who watched an in-scanner ToM movie.…”

“…We leveraged openly accessible adult and developmental data from two previous studies which investigated social cognition in adults and typically developing children 33,28 We further used the adult sample from the Richardson et al 28 dataset. For validation purposes, we also examined adults from the CCC dataset 33 , a recent multimodal resource for exploring social cognition. These datasets contain movie-watching fMRI data of 30 and 58 adults, respectively.…”

“…fMRI acquisition parameters for structural (T1-weighted) and functional MRI data are described in detail elsewhere 33,28 . Briefly, in Richardson et al 28 , whole-brain structural and functional images were acquired on a 3 T Siemens Tim Trio scanner.…”

“…We excluded 8 participants from the Richardson et al dataset for not having sufficient cerebellar coverage. We further excluded 2 participants with poor fMRI data quality from the CCC dataset, as indexed by three independent raters' visual examination of the preprocessed data 33 . Thus, informed consent (or the consent of the legal guardian, in case the participants were children).…”

“…Briefly, in Richardson et al 28 , whole-brain structural and functional images were acquired on a 3 T Siemens Tim Trio scanner. Children under five used a custom 32-channel phased-array head coil to accommodate for their head size, while older participants used a standard Structural and functional data in the CCC dataset 33 were acquired with a 3 T Siemens Prisma.Fit scanner with a 32-channel head receive array coil. The CCC dataset contains multiple acquisition protocols reflecting changes in MRI data collection throughout the years of the project.…”