Calretinin‐immunoreactive cells and fibers in the human amygdaloid complex

Sorvari, Heikki; Pitkänen, Asla

doi:10.1002/(sici)1096-9861(19960527)369:2<188::aid-cne2>3.0.co;2-#

Cited by 48 publications

(31 citation statements)

References 42 publications

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“…These neuronal types represent nonpyramidal neurons that most probably represent local circuit neurons. They closely correspond to those nerve cell types described in the adult amygdala by Sorvari et al 23,24 These investigators clearly correlated these calbindin‐ and calretinin‐positive nerve cells with the neuronal types (class II and class III nerve cells) described by Braak and Braak 25. These nonpyramidal neurons resemble stellate neurons of the cerebral cortex.…”

Section: Expression Of Calbindin and Calretinin: Neuronal Differentiasupporting

confidence: 85%

Ontogeny of the Human Amygdala

Ulfig

Setzer

Böhl

2003

Annals of the New York Academy of Sciences

117

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Data on the fetal development of the human amygdala is reviewed with special reference to major ontogenetic events. In the fifth gestational month, the inferior portion of the amygdala reveals cell‐dense columns merging with the ganglionic eminence (proliferative zone) in Nissl‐stained sections. These columns contain vimentin‐positive fibers and can therefore be regarded as migrational routes. In the sixth and seventh months, distinct reorganization of the cytoarchitectonics takes place. The sequential occurrence of afferens can be visualized using anti‐GAP‐43; moreover, outgrowing axons appear to reach the periphery of the ganglionic eminence. The latter may thus represent an intermediate target for growing axons using anti‐calbindin and anti‐calretinin. Migrating and immature amygdaloid neurons can be shown in the fifth month. From the eighth month onwards, various nonpyramidal neurons and pyramidal neurons are immunolabeled. Transient expression of calretinin in pyramidal neurons is observed. When punctate calbindin and calretinin immunostaining in the fifth and eighth months is compared, distinct redistribution is observed. On the whole, it is apparent that the amygdala has reached a high degree of maturity in the eighth month. At this developmental stage, AKAP79, being enriched in postsynaptic densities, shows a characteristic nuclear‐specific distribution pattern. The latter largely corresponds to the expression pattern of NMDAR1. Thus, AKAP79 may have a preference for anchoring enzymes to glutamate receptors. The aforementioned results provide a basis for investigations on subtle changes in pathologically altered material, such as hemorrhage, in the ganglionic eminence of preterm infants.

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Section: Expression Of Calbindin and Calretinin: Neuronal Differentiasupporting

confidence: 85%

Ontogeny of the Human Amygdala

Ulfig

Setzer

Böhl

2003

Annals of the New York Academy of Sciences

117

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“…Immunoreactivity for parvalbumin and calretinin in both neuronal somata and neuropil has been extensively reported in the temporal amygdala of eutherians (Pv- Celio, 1990;Härtig et al, 1995;Sorvari et al, 1995;Smith et al, 1998Smith et al, , 2000Morys et al, 1999;Kemppainen and Pitkänen, 2000;Pitkänen and Kemppainen, 2002) (Cr- Résibois and Rogers, 1992;McDonald, 1994;Krzywkowski et al, 1995;Sorvari et al, 1996aSorvari et al, , 1998Kemppainen and Pitkänen, 2000). We were unable to find any immunoreactivity for parvalbumin ( Fig.…”

Section: The Absence Of Parvalbumin and Calretinin Immunoreactivity Imentioning

confidence: 62%

Cyto- and chemoarchitecture of the amygdala of a monotreme, Tachyglossus aculeatus (the short-beaked echidna)

Ashwell¹,

Hardman²,

Paxinos³

2005

Journal of Chemical Neuroanatomy

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“…GABAergic interneurons comprise three subtypes, calbindin (CB)‐positive, parvalbumin (PV)‐positive, and calretinin (CR)‐positive (Sorvari et al . ; Muller et al . ; Woodruff and Sah ).…”

Section: Resultsmentioning

confidence: 99%

Evidence of altered depression and dementia‐related proteins in the brains of young rats after ovariectomy

Fang

Zeng

et al. 2018

Journal of Neurochemistry

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Menopause, a risk factor for brain dysfunction in women, is characterized by neuropsychological symptoms including depression and dementia, which are closely related to alterations in different brain regions after menopause. However, little is known about the variability in pathophysiologic changes associated with menopause in the brain. Here, we observed that menopause in rats induced by bilateral ovariectomy (OVX) showed depressive and dementia-related behaviors along with neuronal loss in the prefrontal cortex (PFC), hippocampus (HIP), hypothalamus (HYP), and amygdala (AMY) by Nissl staining. Meanwhile, by immunohistochemical staining, increased microglia in the HIP and AMY and increased astrocytes in the PFC, HYP, and AMY were shown. Using quantitative proteomics, we identified 146 differentially expressed proteins in the brains of OVX rats, for example, 20 in the PFC, 41 in the HIP, 17 in the HYP, and 79 in the AMY, and performed further detection by western blotting. A link between neuronal loss and apoptosis was suggested, as evidenced by increases in adenylate kinase 2 (AK2), B-cell lymphoma 2 associated X (Bax), cleaved caspase 3, and phosphorylated p53 and decreases in Huntingtin-interacting protein K, hexokinase, and phosphorylated B-cell lymphoma 2 (Bcl-2), and apoptosis might be triggered by endoplasmic reticulum stress (probed by increased glucose-regulated protein 78 (GRP78), cleaved caspase 12, phosphorylated protein kinase R (PKR)-like endoplasmic reticulum kinase, inositol-requiring enzyme-1 and activating transcription factor 6), and mitochondrial dysfunction (probed by increased cytochrome c and cleaved caspase 3 and decreased sideroflexin-1 (SFXN1) and NADH dehydrogenase (ubiquinone) 1 α subcomplex 11 (NDUFA11)). Activation of autophagy was also indicated by increased autophagy-related 7, γ-aminobutyric acid (GABA) receptor-associated protein-like 2, and oxysterol-binding protein-related protein 1 and confirmed by increased microtubule-associated protein light chain 3 (LC3II/I), autophagy-related 5, and Beclin1 in the HIP and AMY. In the AMY, which is important in emotion, higher GABA transporter 3 and lower vesicular glutamate transporter 1 levels indicated an imbalance between excitatory and inhibitory neurotransmission, and the increased calretinin and decreased calbindin levels suggested an adjustment of GABAergic transmission after OVX. In addition, cytoskeletal abnormalities including tau hyperphosphorylation, dysregulated Ca² signals, and glutamic synaptic impairments were observed in the brains of OVX rats. Collectively, our study showed the changes in different brain regions related to depression and dementia during menopause.

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Calretinin‐immunoreactive cells and fibers in the human amygdaloid complex

Cited by 48 publications

References 42 publications

Ontogeny of the Human Amygdala

Ontogeny of the Human Amygdala

Cyto- and chemoarchitecture of the amygdala of a monotreme, Tachyglossus aculeatus (the short-beaked echidna)

Evidence of altered depression and dementia‐related proteins in the brains of young rats after ovariectomy

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