Calreticulin (CALR) Promotes Ionophore-Induced Microneme Secretion in Toxoplasma gondii
Zhili Shan,
Xingju Song,
Xu Yang
et al.
Abstract:The flow of calcium ions (Ca2+) is involved in numerous vital activities of Toxoplasma gondii. Calreticulin is a type of Ca2+-binding protein in the endoplasmic reticulum (ER), that is involved in Ca2+ signaling pathway regulation, Ca2+ storage, and protein folding. In this work, the calreticulin (CALR), a protein predicted to possess a conserved domain of calreticulin in T. gondii, was characterized. The CALR localized in the ER. Using reverse genetics, we discovered that CALR is not necessary for the lytic c… Show more
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