Calprotectin as a marker of inflammation in cystic fibrosis.

Golden, Barbara E.; Clohessy, Paul A.; Russell, Graham; Fagerhol, Magne K.

doi:10.1136/adc.74.2.136

Cited by 72 publications

(64 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Previous studies demonstrated its usefulness in active rheumatic disease [5,11], cystic fibrosis [12], pulmonary infections [13], and several other diseases [2]. In all cases the differences between normal and pathological levels suggested a diagnostic potential for Cal assay.…”

Section: Discussionmentioning

confidence: 85%

Plasma Calprotectin Levels in Patients Suffering from Acute Pancreatitis

Carroccio

Rocco²,

Rabitti³

et al. 2006

Dig Dis Sci

View full text Add to dashboard Cite

Calprotectin (Cal) concentration is elevated in acute inflammatory reactions and its increase in the plasma suggests a diagnostic potential for Cal assay. This study aimed (a) to evaluate the Cal plasma levels in patients suffering from acute pancreatitis (AP) and (b) to assess whether early assay of Cal plasma levels can be helpful in assessment of the severity of AP. Forty-six consecutive patients, median age 45 years, suffering from a first attack of AP were recruited at two medical centers. Data collected on admission included age, sex, delay between pain onset and admission, and Glasgow score. A severe outcome was defined according to the Atlanta criteria. AP was defined as edematous or necrotic according to the CT findings. Plasma Cal and serum C reactive protein (CRP) were assayed in all patients within the first 24 hr after hospitalization. Sixty subjects suffering from blood hypertension were recruited as controls. Plasma Cal was measured by a commercial ELISA system. In all AP patients and in none of the controls, plasma Cal concentration was higher than the normal limit. Cal values in AP pa- tients were significantly higher than in controls (P < 0.0001). There was not a statistically significant difference in Cal values between patients with severe and patients with mild AP. Plasma Cal values did not differ in necrotizing and edematous AP. During the follow-up plasma Cal was reassayed in six of the patients with abdominal fluid collection and the values were higher in the two patients with infected necrosis. We conclude that plasma Cal is elevated in patients with AP but it is not a useful marker for early prediction of pancreatitis severity. Further studies could evaluate its usefulness in pancreatic infected necrosis.

show abstract

Section: Discussionmentioning

confidence: 85%

Plasma Calprotectin Levels in Patients Suffering from Acute Pancreatitis

Carroccio

Rocco²,

Rabitti³

et al. 2006

Dig Dis Sci

View full text Add to dashboard Cite

show abstract

“…S100A8/A9 (calprotectin) and S100A8 were upregulated to a greater extent than other altered proteins in the serums of THD cases and showed increased amyloid-related serum protein (SAA) and plasma glutathione peroxidase (GPX3), suggesting elevated inflammatory responses and oxidative stress in THD. S100A8 and S100A8/A9 are involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation and have been identified as biomarkers for acute and chronic inflammation 15) , chronic bronchitis and cystic fibrosis 16) , chronic inflammatory bowel disease 17) and systemic lupus erythematosus 18) . Recently, S100A8/A9 has been identified as an important endogenous damageassociated molecular pattern that binds to Toll-like receptor 4 and plays a pivotal role during amplification of inflammation and represents a promising new therapeutic target 19) .…”

Section: Discussionmentioning

confidence: 99%

Upregulation of Calprotectin and Downregulation of Retinol Binding Protein in the Serum of Workers with Trichloroethylene‐induced Hypersensitivity Dermatitis

Huang

Fei

Yang

et al. 2012

Journal of Occupational Health

View full text Add to dashboard Cite

Zhenlie HUANG, et al.: Higher Calprotectin and Lower RBP4 in THD Workers than trichloroethylene exposure. Conclusions: The pathophysiological processes underlying THD may involve elevated inflammatory responses and oxidative stress, inhibition of vitamin transport, depression of fatty acid biosynthesis, loss of extracellular actin scavenger, increase in oxygen transport, dysfunction in lipid transport, proteolysis and glycolysis. The combination of higher calprotectin and lower RBP4 levels in the serum could be used as potential biomarkers of THD. (J Occup Health 2012; 54: 299-309)

show abstract

“…30) In contrast, no substantial increase was observed in osteoarthritis. 30) An increase in blood calprotectin concentration was also reported in patients with Crohn's disease, 34) colorectal carcinoma, 35) cystic fibrosis, 36,37) multiple sclerosis, 38) human immunodeficiency virus (HIV) infection, 39) and patients who had undergone major surgery. 42) A more intense increase in calprotectin concentration has been observed in body fluid from local inflammatory sites than in blood.…”

Section: Pathological States In Which Calpro-tectin Is Upregulatedmentioning

confidence: 99%

“…11,[29][30][31][32][33][34][35][36][37][38][39][40][41] Examples of the inflammatory states in which extracellular calprotectin reportedly increases are depicted in Table 1. The calprotectin-upregulated pathological states were also listed in more detail in a review by Johne et al 21) Berntzen et al reported that in healthy human serum/ plasma, the concentration of calprotectin was less than 1 mg/ml, while the plasma concentration of patients with rheumatoid arthritis (RA) was reportedly increased to approximately 10-fold higher concentrations as mean values.…”

Section: Pathological States In Which Calpro-tectin Is Upregulatedmentioning

confidence: 99%

Calprotectin (S100A8/S100A9), an Inflammatory Protein Complex from Neutrophils with a Broad Apoptosis-Inducing Activity

Yui

Nakatani

Mikami

2003

Biological & Pharmaceutical Bulletin

275

209

View full text Add to dashboard Cite

Calprotectin, a complex of two calcium-binding proteins that belong to the S100 protein family, is abundant in the cytosolic fraction of neutrophils. A high level of calprotectin reportedly exists in extracellular fluid during various inflammatory conditions, such as rheumatoid arthritis, cystic fibrosis and abscesses. However, the exact biological role(s) of the factor is now under investigation. We recently observed that neutrophils contain a factor that shows growth-inhibitory and apoptosis-inducing activities against various cell types including tumor cells and normal fibroblasts, and we identified that factor as calprotectin. The findings suggest that calprotectin exerts a regulatory activity in inflammatory processes through its effect on the survival or growth states of cells participating in the inflammatory reaction. It is also possible that calprotectin, at a high concentration, might have a deleterious effect on fibroblasts and influence the recovery of inflammatory tissue. Therefore, the protein factor may be a new drug target to control inflammatory reactions. We found that a few of the Amaryllidaceae alkaloids effectively inhibited the growth-inhibitory and apoptosis-inducing activities of calprotectin. In this article, we focus on the biological functions of calprotectin in extracellular fluids, focusing on its apoptosis-inducing activity.

show abstract

Calprotectin as a marker of inflammation in cystic fibrosis.

Abstract: Calprotectin is an abundant neutrophil cytosolic protein released during neutrophil activation or death.

Cited by 72 publications

References 18 publications

Plasma Calprotectin Levels in Patients Suffering from Acute Pancreatitis

Plasma Calprotectin Levels in Patients Suffering from Acute Pancreatitis

Upregulation of Calprotectin and Downregulation of Retinol Binding Protein in the Serum of Workers with Trichloroethylene‐induced Hypersensitivity Dermatitis

Calprotectin (S100A8/S100A9), an Inflammatory Protein Complex from Neutrophils with a Broad Apoptosis-Inducing Activity

Contact Info

Product

Resources

About