Calprotectin, an Emerging Biomarker of Interest in COVID-19: A Systematic Review and Meta-Analysis

Udeh, Raphael; Advani, Shailesh; Romualdo, Luis García de Guadiana; Dolja‐Gore, Xenia

doi:10.3390/jcm10040775

Cited by 42 publications

(49 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In this regard, it has been reported that Calprotectin, a myeloid-related inflammatory protein, also known as MRP8/14, is a heterodimer composed of two intracellular calcium-binding proteins, S100A8 and S100A9, expressed not only in muscle but also in human neutrophils, monocytes and macrophages. Elevated plasma levels of calprotectin have been reported in a variety of chronic inflammatory conditions, including rheumatoid arthritis, inflammatory bowel disease, cancer and COVID-19 disease [103,104].…”

Section: S-100mentioning

confidence: 99%

Biological Aspects of Selected Myokines in Skeletal Muscle: Focus on Aging

Mancinelli

Checcaglini

Coscia

et al. 2021

IJMS

View full text Add to dashboard Cite

In the last decade, clear evidence has emerged that the cellular components of skeletal muscle are important sites for the release of proteins and peptides called “myokines”, suggesting that skeletal muscle plays the role of a secretory organ. After their secretion by muscles, these factors serve many biological functions, including the exertion of complex autocrine, paracrine and/or endocrine effects. In sum, myokines affect complex multi-organ processes, such as skeletal muscle trophism, metabolism, angiogenesis and immunological response to different physiological (physical activity, aging, etc.) or pathological states (cachexia, dysmetabolic conditions, chronic inflammation, etc.). The aim of this review is to describe in detail a number of myokines that are, to varying degrees, involved in skeletal muscle aging processes and belong to the group of proteins present in the functional environment surrounding the muscle cell known as the “Niche”. The particular myokines described are those that, acting both from within the cell and in an autocrine manner, have a defined relationship with the modulation of oxidative stress in muscle cells (mature or stem) involved in the regulatory (metabolic or regenerative) processes of muscle aging. Myostatin, IGF-1, NGF, S100 and irisin are examples of specific myokines that have peculiar features in their mechanisms of action. In particular, the potential role of one of the most recently characterized myokines—irisin, directly linked to an active lifestyle—in reducing if not reversing senescence-induced oxidative damage is discussed in terms of its possible application as an agent able to counteract the deleterious effects of muscle aging.

show abstract

Section: S-100mentioning

confidence: 99%

Biological Aspects of Selected Myokines in Skeletal Muscle: Focus on Aging

Mancinelli

Checcaglini

Coscia

et al. 2021

IJMS

View full text Add to dashboard Cite

show abstract

“…Recent meta-analysis with eight included studies as well as other study reported that serum calprotectin (SC) was increased in COVID-19 patients, especially in cases admitted to the intensive care units (ICU) 11,12 . Previously, calprotectin was introduced as a diagnostic biomarker for intestinal mucosal damage 13 .…”

Section: Intestinal Epithelial Cell Damage Caused By Sars-covmentioning

confidence: 99%

“…Samples were collected during the acute phase of the disease. The median time from symptom onset to sampling was 9 days (9)(10)(11)(12)(13). Out of all the patients, 27.14% (n = 19) presented to the hospital with severe disease (see "Methods" for definitions); of these, five patients (7.17%) were admitted to the intensive care unit (ICU), four (5.71%) of whom died, and the other 66 patients were discharged after 7 (6-10) days.…”

Section: Patient Demographics and Clinical Characteristicsmentioning

confidence: 99%

“…In addition, tissue damaged by SARS-CoV-2 infection induces the recruitment and activation of inflammatory cytokine-producing immune cells, especially neutrophils and macrophages, in an amplifying loop 9 . A marked neutrophilia is associated with COVID-19 severity which in turn, induces a massive release of S100A8/S100A9 calprotectin 10 .Recent meta-analysis with eight included studies as well as other study reported that serum calprotectin (SC) was increased in COVID-19 patients, especially in cases admitted to the intensive care units (ICU) 11,12 . Previously, calprotectin was introduced as a diagnostic biomarker for intestinal mucosal damage 13 .…”

mentioning

confidence: 99%

See 1 more Smart Citation

Elevated fecal and serum calprotectin in COVID-19 are not consistent with gastrointestinal symptoms

Shokri-Afra

Alikhani

Moradipoodeh

et al. 2021

Sci Rep

View full text Add to dashboard Cite

Intestinal epithelial cell damage caused by SARS-CoV-2 infection was thought to be associated with gastrointestinal symptoms and decreased fecal consistency. The association of the gastrointestinal symptoms with the COVID-19-mediated inflammatory response triggered by the gastrointestinal immune system was investigated in this paper. Intestinal inflammation marker fecal calprotectin along with serum calprotectin and other inflammatory markers were measured in COVID-19 cases with and without GI manifestations as well as healthy individuals. Analyses were performed to compare COVID-19 patient subgroups and healthy controls and examine the relationship between fecal and serum calprotectin levels with gastrointestinal symptoms and disease severity. COVID-19 patients (n = 70) were found to have markedly elevated median levels of fecal (124.3 vs. 25.0 µg/g; P < 0/0001) and serum calprotectin (3500 vs. 1060 ng/mL; P < 0/0001) compared with uninfected controls. Fecal and serum calprotectin levels were not significantly different between COVID-19 patients who displayed GI symptoms and those who did not. Compared with other acute phase markers, both fecal and serum calprotectin were superior in identifying COVID-19 patients who progressed to severe illness. Although the progression of COVID-19 disease is marked by an elevation of fecal and serum calprotectin, gastrointestinal symptoms or diarrhea were not correlated with calprotectin increase level.

show abstract

“…This implies that patients affected by IBD should also be tested for COVID-19 in the case of flare and diarrhoea ( Jena et al, 2021 ). Moreover, SARS-CoV-2 has also been found in the stool of infected patients, and the association with high faecal calprotectin levels in COVID-19 is the proof of gut tropism ( Udeh et al, 2021 ).…”

Section: Liquid Biopsymentioning

confidence: 99%

Beyond liquid biopsy: Toward non-invasive assays for distanced cancer diagnostics in pandemics

Ferrara

Zoupanou

Primiceri

et al. 2022

Biosensors and Bioelectronics

View full text Add to dashboard Cite

Liquid biopsy technologies have seen a significant improvement in the last decade, offering the possibility of reliable analysis and diagnosis from several biological fluids. The use of these technologies can overcome the limits of standard clinical methods, related to invasiveness and poor patient compliance. Along with this there are now mature examples of lab-on-chips (LOC) which are available and could be an emerging and breakthrough technology for the present and near-future clinical demands that provide sample treatment, reagent addition and analysis in a sample-in/answer-out approach. The possibility of combining non-invasive liquid biopsy and LOC technologies could greatly assist in the current need for minimizing exposure and transmission risks. The recent and ongoing pandemic outbreak of SARS-CoV-2, indeed, has heavily influenced all aspects of life worldwide. Ordinary tasks have been forced to switch from “in presence” to “distanced”, limiting the possibilities for a large number of activities in all fields of life outside of the home. Unfortunately, one of the settings in which physical distancing has assumed noteworthy consequences is the screening, diagnosis and follow-up of diseases. In this review, we analyse biological fluids that are easily collected without the intervention of specialized personnel and the possibility that they may be used -or not-for innovative diagnostic assays. We consider their advantages and limitations, mainly due to stability and storage and their integration into Point-of-Care diagnostics, demonstrating that technologies in some cases are mature enough to meet current clinical needs.

show abstract

Calprotectin, an Emerging Biomarker of Interest in COVID-19: A Systematic Review and Meta-Analysis

Cited by 42 publications

References 37 publications

Biological Aspects of Selected Myokines in Skeletal Muscle: Focus on Aging

Biological Aspects of Selected Myokines in Skeletal Muscle: Focus on Aging

Elevated fecal and serum calprotectin in COVID-19 are not consistent with gastrointestinal symptoms

Beyond liquid biopsy: Toward non-invasive assays for distanced cancer diagnostics in pandemics

Contact Info

Product

Resources

About