Calotropis-induced corneal toxicity in Indian medicinal use: A rare case report with review of literature

Jain, Vaibhav; Kesarwani, Divya; Yadav, Vishal; Sharma, Kumudini

doi:10.4103/tjosr.tjosr_95_19

Cited by 3 publications

(5 citation statements)

References 1 publication

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“…-Latex caused immediate mild to moderate or severe corneal damage with painless blurring of vision. Low endothelial cell count was also reported by some studies suggesting that the cause of corneal oedema is endothelial toxicity [76][77][78][79]. In addition, cases of iridocyclitis [76 & 77] and associated secondary glaucoma [76] have been reported.…”

Section: Mechanism Of Toxicitymentioning

confidence: 78%

A Review on Some Cultivated and Native Poisonous Plants in Aden Governorate, Yemen

Alasbahi

Al-Hawshabi

2021

Electron. J. Univ. Aden Basic Appl. Sci.

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Plant poisoning is a health concern in many countries where plants are used either accidently, especially among children, or intentionally for purposes such as assassination, suicide, hunting, fishing and treating various diseases. Presently, despite the implementation of toxicology surveillance systems in many countries, plant poisoning continues to be a preventable cause of morbidity and mortality. In the Aden governorate of Yemen, there are no laws or regulations for the prevention of plant poisoning, despite the existence of several poisonous species in gardens, and as roadside trees planted by the local authority, or growing wildly in public areas. In addition, there is a lack of scientific studies on the risks of these poisonous plants. Therefore, we undertook this study, based on scientific review, to document and illustrate the botanical, geographical and toxicological characteristics of fourteen poisonous plants collected from different districts of Aden governorate. The documented poisonous species (6 species) belong to Apocynaceae followed by Fabaceae (2 species), whereas Aristolochiaceae, Cucurbitaceae, Dracaenaceae, Euphorbiaceae, Meliaceae, and Verbenaceae are represented by one species each. The toxic parts of the majority of studied poisonous species are the whole plant, latex, seeds, and fruits. Cardiotoxicity, cytotoxicity, gastrointestinal toxicity, and inflammation of skin and mucous membrane are the main clinical manifestations. They are caused by varying amounts of plant toxins such as cardiac glycosides in Calotropis procera, Cryptostegia grandiflora, Nerium oleander and Thevetia peruviana, and cytotoxic toxins such as toxalbumins in Abrus precatorius and Ricinus communis, aristolochic acids in Aristolochia bracteolate, and vinca alkaloids in Catharanthus roseus, as well as gastrointestinal toxins such as cucurbitacins in Citrullus colocynthis, and tannins in Caesalpinia pulcherrima. Inflammation of skin and mucous membrane is caused by calcium oxalate crystals in Calotropis procera latex, and soluble protein in Cryptostegia grandiflora latex. Moreover, Azadirachta indica caused a number of toxicities attributed partially to tetranortriterpenoids, while Sansevieria trifasciata toxicity was reported to be low. The significance of this work is to promote the awareness among the local authority to take legal actions against plant poisoning. In addition, it provides the physicians with scientific information for the diagnosis and treatment of poisoning by some plants. It is hoped that this study motivates researchers to conduct further research on poisonous plants throughout Yemen.

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Section: Mechanism Of Toxicitymentioning

confidence: 78%

A Review on Some Cultivated and Native Poisonous Plants in Aden Governorate, Yemen

Alasbahi

Al-Hawshabi

2021

Electron. J. Univ. Aden Basic Appl. Sci.

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“…This plant has an advantage of growing in abundance in unfavourable harsh conditions. It can withstand warm climates, enduring dry, sandy, and alkaline soils [33] . This makes this shrub ubiquitous to the Sultanate, being noted on several roadsides and inside private gardens and farms.…”

Section: Locationmentioning

confidence: 99%

“…Headache, tooth pain and arthritic joint pain are all ailments believed to benefit from this herb [23] . The poultice of dried leaves is used for speeding up the healing of skin disorders, infected wounds, painful joints in addition to indigestion and liver problems [7,33] . It is also used for treating expectant mothers with blood clots [7] .…”

Section: Usesmentioning

confidence: 99%

“…Another use of this plant is in treating scorpion bites, where a section of the root (specifically from the western side) is pulled, mashed and mixed with lime juice then applied on the site [7] . A recent article on the practices in India noted the use of this plant for treating baldness, sprained joints and paralysed limbs [33] .…”

Section: Scorpion Bitesmentioning

confidence: 99%

“…However, several studies report that eye exposure can result in ocular toxicity. The extent of damage can range from kerato-conjunctivitis to complete visual loss [33,34,37] . Calotropis procera can also cause myocardial toxicity, the extent of which depends on the amount of cardio-active steroids ingested.…”

Section: Side Effectsmentioning

confidence: 99%

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Uses, local practices and side effects of six medicinal plants in the sultanate of Oman: A review article

Lawati¹,

Lawati²

2020

J. Med. Plants Stud.

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Over the years, ethno-botanical and traditional medicine has received great interest by our society. The World Health Organisation (WHO) has sixty herbal medicines registered for ethno-medical usage in Oman, with acknowledged use by 80-99% of the population. These plants are, collectively, believed to have analgesic, anti-microbial, anti-oxidant, anti-cancer, anti-viral and in some instances immune modulatory properties. Despite being widely used locally, the majority of people are oblivious about the possible side effects that follow erroneous usage. As plants have been widely incorporated in traditional medicine, plant poisoning has become a worldwide concern. Locally, these plants appear to be readily available all over the Country. This article discusses six different plants that are used frequently by the natives of Oman and are widely available here; being Nerium oleander, Adenium obesum, Euphorbia cactus, Ficus cordata, Datura metel and Calotropis procera. The aim is to highlight the distribution of those plants in the Country, their medical and non-medical uses, poisonous parts and finally toxicity and possible side effects. The objective is to increase awareness among physicians, health care workers and the public about plants and their effects.

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From Temple to Emergency Room: A Chemical Injury Case Report

Prabhudesai,

Lune

2024

Cureus

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Calotropis-induced corneal toxicity in Indian medicinal use: A rare case report with review of literature

Cited by 3 publications

References 1 publication

A Review on Some Cultivated and Native Poisonous Plants in Aden Governorate, Yemen

A Review on Some Cultivated and Native Poisonous Plants in Aden Governorate, Yemen

Uses, local practices and side effects of six medicinal plants in the sultanate of Oman: A review article

From Temple to Emergency Room: A Chemical Injury Case Report

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