Calotropin, a cardenolide from Calotropis gigantea, with Wnt signal inhibition activity through increase of casein kinase 1α

Park, HY; Toume, Kazufumi; Arai, Ma; Sadhu, SK; Ahmed, Firoj; Ishibashi, Masami

doi:10.1055/s-0034-1382608

Cited by 2 publications

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It has been shown that the tumor obtained from the calotropin-treatment group was reduced in volume and weight. Another research on colon cancer cells (SW480 colon adenocarcinoma cell line) marked calotropin as an anticancer agent which inhibits the Wnt signalling pathway by decreasing nuclear and cytosolic located β-catenin in a dose- dependent manner and leading to degradation of β-catenin by increasing the phosphorylation of β-catenin through casein kinase 1α (CK1α) (Park et al, 2014). Additionally, they concluded that calotropin increased mRNA and protein levels of CK1α.…”

Section: Colorectal Cancermentioning

confidence: 99%

An updated pharmacological insight into calotropin as a potential therapeutic agent in cancer

et al. 2023

View full text Add to dashboard Cite

Calotropin is a pharmacologically active compound isolated from milkweed plants like Calotropis procera, Calotropis gigantea, and Asclepias currasavica that belong to the Asclepiadaceae family. All of these plants are recognised as medical traditional plants used in Asian countries. Calotropin is identified as a highly potent cardenolide that has a similar chemical structure to cardiac glycosides (such as digoxin and digitoxin). During the last few years, cytotoxic and antitumor effects of cardenolides glycosides have been reported more frequently. Among cardenolides, calotropin is identified as the most promising agent. In this updated and comprehensive review, we aimed to analyze and discuss the specific mechanisms and molecular targets of calotropin in cancer treatment to open new perspectives for the adjuvant treatment of different types of cancer. The effects of calotropin on cancer have been extensively studied in preclinical pharmacological studies in vitro using cancer cell lines and in vivo in experimental animal models that have targeted antitumor mechanisms and anticancer signaling pathways. The analyzed information from the specialized literature was obtained from scientific databases until December 2022, mainly from PubMed/MedLine, Google Scholar, Scopus, Web of Science, and Science Direct databases using specific MeSH search terms. The results of our analysis demonstrate that calotropin can be a potential chemotherapeutic/chemopreventive adjunctive agent in cancer pharmacotherapeutic management.

show abstract

Section: Colorectal Cancermentioning

confidence: 99%