Calorimetric Studies on the Phenolic Glycoside D(–)-Salicin

Pinto, Susana; Diogo, Hermı́nio P.

doi:10.1002/jps.21393

Cited by 6 publications

(2 citation statements)

References 32 publications

(29 reference statements)

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“…Glycosidic bonds may be hydrolysed in the presence of dilute acid or by a specific enzyme (e.g., β-glucosidase) (Pinto & Diogo, 2008). Controlled enzymatic hydrolysis occurs within the cytoplasm of cells during normal metabolic functioning, while rapid and indiscriminate enzymatic hydrolysis occurs throughout the natural matrix of the plant tissue when cellular structures are disrupted and the enzymes are able to access stored glycosides.…”

Section: Degradationmentioning

confidence: 99%

Hitting the sweet spot: A systematic review of the bioactivity and health benefits of phenolic glycosides from medicinally used plants

Johnson

Mani

Broszczak

et al. 2021

Phytotherapy Research

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Phenolic acid and flavonoid glycosides form a varied class of naturally occurring compounds, characterised by high polarity-resulting from the glycone moiety-and the presence of multiple phenol functionalities, which often leads to strong antioxidant activity.Phenolic glycosides, and in particular flavonoid glycosides, may possess strong bioactive properties with broad spectrum activity. This systematic literature review provides a detailed overview of 28 studies examining the biological activity of phenolic and flavonoid glycosides from plant sources, highlighting the potential of these compounds as therapeutic agents. The activity of glycosides depends upon the biological activity type, identity of the aglycone and the identity and specific location of the glycone moiety. From studies reporting the activity of both glycosides and their respective aglycones, phenolic glycosides appear to generally be a storage/reserve pool of precursors of more bioactive compounds. The glycosylated compounds are likely to be more bioavailable compared to their aglycone forms, due to the presence of the sugar moieties. Hydrolysis of the glycoside in the in vivo environment would release the free aglycone, potentiating their biological activity. However, further high-quality studies are needed to firmly establish the clinical efficacy of glycosides from many of the plant species studied.

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Section: Degradationmentioning

confidence: 99%

Hitting the sweet spot: A systematic review of the bioactivity and health benefits of phenolic glycosides from medicinally used plants

Johnson

Mani

Broszczak

et al. 2021

Phytotherapy Research

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“…Therefore, we hypothesized that another organism within the microbiome might act as a facilitator of the interaction between Populus and Pseudomonas species. Salicin metabolism has been reported to result in the release of salicyl alcohol [ 15 , 16 ]. Utilization of benzyl alcohol (a compound related to salicyl alcohol) through the naphthalene degradation pathway has been studied in Pseudomonas putida CSV86, and the enzymes benzyl alcohol dehydrogenase and benzaldehyde dehydrogenase required for the transformation of benzyl alcohol to benzoate have been characterized [ 17 ].…”

Section: Introductionmentioning

confidence: 99%

Mechanism for Utilization of the Populus-Derived Metabolite Salicin by a Pseudomonas—Rahnella Co-Culture

et al. 2023

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Pseudomonas fluorescens GM16 associates with Populus, a model plant in biofuel production. Populus releases abundant phenolic glycosides such as salicin, but P. fluorescens GM16 cannot utilize salicin, whereas Pseudomonas strains are known to utilize compounds similar to the aglycone moiety of salicin–salicyl alcohol. We propose that the association of Pseudomonas to Populus is mediated by another organism (such as Rahnella aquatilis OV744) that degrades the glucosyl group of salicin. In this study, we demonstrate that in the Rahnella–Pseudomonas salicin co-culture model, Rahnella grows by degrading salicin to glucose 6-phosphate and salicyl alcohol which is secreted out and is subsequently utilized by P. fluorescens GM16 for its growth. Using various quantitative approaches, we elucidate the individual pathways for salicin and salicyl alcohol metabolism present in Rahnella and Pseudomonas, respectively. Furthermore, we were able to establish that the salicyl alcohol cross-feeding interaction between the two strains on salicin medium is carried out through the combination of their respective individual pathways. The research presents one of the potential advantages of salicyl alcohol release by strains such as Rahnella, and how phenolic glycosides could be involved in attracting multiple types of bacteria into the Populus microbiome.

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Phenolic compounds and their anti-oxidative properties and protein kinase inhibition from the Chinese mangrove plant Laguncularia racemosa

Shi

Bayer

et al. 2010

Phytochemistry

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Calorimetric Studies on the Phenolic Glycoside D(–)-Salicin

Cited by 6 publications

References 32 publications

Hitting the sweet spot: A systematic review of the bioactivity and health benefits of phenolic glycosides from medicinally used plants

Hitting the sweet spot: A systematic review of the bioactivity and health benefits of phenolic glycosides from medicinally used plants

Mechanism for Utilization of the Populus-Derived Metabolite Salicin by a Pseudomonas—Rahnella Co-Culture

Phenolic compounds and their anti-oxidative properties and protein kinase inhibition from the Chinese mangrove plant Laguncularia racemosa

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