Calorimetric studies on saturated mixed-chain lecithin-water systems. Nonequivalence of acyl chains in the thermotropic phase transition

Stümpel, J.; Nicksch, Alfar; Eibl, Hansjörg

doi:10.1021/bi00506a033

Cited by 56 publications

(15 citation statements)

References 17 publications

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“…A complete set of the transition temperature data for phosphatidylcholines with two different chains and between 10 and 18 carbon atoms per hydrocarbon has been published by Mattai et al (1987); it is also reproduced in the insert to Figure 4. Less extensive and complete, but confirmatory, results have been reported by other authors (Keough & Davis, 1979;Chen & Sturtevant, 1981;Mason et al, 1981; Stümpel et al, 1981Stümpel et al, , 1983Coolbear et al, 1983;Eriksson et al, 1985;Fragata et al, 1985).…”

Section: Hydrocarbon Effectssupporting

confidence: 76%

How membrane chain-melting phase-transition temperature is affected by the lipid chain asymmetry and degree of unsaturation: an effective chain-length model

Cevc¹

1991

Biochemistry

144

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Hydrocarbon effects on the lipid chain-melting phase-transition temperature are analyzed. The membrane fluidization temperature is shown to increase with the effective chain length, which is proportional to the thickness of the well-packed hydrocarbon region. The latter, as a rule, increases with the length of the longest ordered and aligned segment on each chain. This conclusion is independent of the cause for the reduced chain packing in membrane interior: chain unsaturation (which effectively decouples the two hydrocarbon segments disjoined by a double bond) or chain asymmetry (which causes the terminal hydrocarbon segments to lose close contact) both affect the bilayer chain-melting phase-transition temperature comparably on the effective chain-length scale. Thermodynamic consequences of the trans unsaturation are approximately 50% smaller than the effects of the double bonds in the cis conformation, owing to the smaller membrane perturbation by the former double bonds. A simple quantitative model is introduced for the analysis of the phospholipid chain-melting phase behavior. This new model permits quantitative predictions of the chain-melting transition temperature solely on the basis of the known lipid chemical composition. It also explains lipid sensitivity to the hydrocarbon type and attachment. The model agreement with the experimental data is usually better than to within 99% and thus comparable to experimental scatter, even when only a few or no adjustable parameters are used. The membrane fluidization temperature is calculated for a number of potentially interesting, also as yet unexplored, phospholipids, and the biological significance of the effective chain-length concept is discussed.

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Section: Hydrocarbon Effectssupporting

confidence: 76%

How membrane chain-melting phase-transition temperature is affected by the lipid chain asymmetry and degree of unsaturation: an effective chain-length model

Cevc¹

1991

Biochemistry

144

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“…This fluid intermediate had been proposed by Stümpel, Nicksch and Eibl [25]. They also saw that changes in tail-length at sn-2 position have more important effects on T m than changes in sn-1.…”

Section: Interdigitationsupporting

confidence: 57%

Phase behavior of selected artificial lipids

Dobner

Brezesinski

2014

Current Opinion in Colloid & Interface Science

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“…The three transition temperatures of the PSPC or MPPC bilayer are larger than the corresponding bilayers of the positional isomer, SPPC or PMPC, respectively. This is because SPPC or PMPC with large chain asymmetry may reduce the stabilization of the L c and gel phases in the bilayer because of the instability for a part of the chain difference between the sn -1 and sn -2 chains [36,37]. …”

Section: Effect Of Acyl Chain Structure On the Phase Behavior Of Pmentioning

confidence: 99%

Thermotropic and Barotropic Phase Behavior of Phosphatidylcholine Bilayers

Matsuki

Goto

Tada

et al. 2013

IJMS

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Bilayers formed by phospholipids are frequently used as model biological membranes in various life science studies. A characteristic feature of phospholipid bilayers is to undergo a structural change called a phase transition in response to environmental changes of their surroundings. In this review, we focus our attention on phase transitions of some major phospholipids contained in biological membranes, phosphatidylcholines (PCs), depending on temperature and pressure. Bilayers of dipalmitoylphosphatidylcholine (DPPC), which is the most representative lipid in model membrane studies, will first be explained. Then, the bilayer phase behavior of various kinds of PCs with different molecular structures is revealed from the temperature–pressure phase diagrams, and the difference in phase stability among these PC bilayers is discussed in connection with the molecular structure of the PC molecules. Furthermore, the solvent effect on the phase behavior is also described briefly.

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Calorimetric studies on saturated mixed-chain lecithin-water systems. Nonequivalence of acyl chains in the thermotropic phase transition

Cited by 56 publications

References 17 publications

How membrane chain-melting phase-transition temperature is affected by the lipid chain asymmetry and degree of unsaturation: an effective chain-length model

How membrane chain-melting phase-transition temperature is affected by the lipid chain asymmetry and degree of unsaturation: an effective chain-length model

Phase behavior of selected artificial lipids

Thermotropic and Barotropic Phase Behavior of Phosphatidylcholine Bilayers

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